A bi-objective turning restriction design problem in urban road networks

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An intersection-movement-based stochastic dynamic user optimal route choice model for assessing network performance

Different from traditional methods, this paper formulates the logit-based stochastic dynamic user optimal (SDUO) route choice problem as a fixed point (FP) problem in terms of intersection movement choice probabilities, which contain travelers’ route information so that the realistic effects of physical queues can be captured in the formulation when a physical-queue traffic flow model is adopted, and that route enumeration and column generation heuristics can be avoided in the solution procedure when efficient path sets are used. The choice probability can be either destination specific or origin–destination specific, resulting into two formulations. To capture the effect of physical queues in these FP formulations, the link transmission model is modified for the network loading and travel time determination. The self-regulated averaging method (SRAM) was adopted to solve the FP formulations. Numerical examples were developed to illustrate the properties of the problem and the effectiveness of the solution method. The proposed models were further used to evaluate the effect of information quality and road network improvement on the network performance in terms of total system travel time (TSTT) and the cost of total vehicle emissions (CTVE). Numerical results show that providing better information quality, enhancing link outflow capacity, or constructing a new road can lead to poor network performance.postprin

A nonlinear equation system approach to the dynamic stochastic user equilibrium simultaneous route and departure time choice problem

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Post-Tension Relationship between Buddhists and Muslims in Sri Lanka

Sri Lanka is a multi religious, multi cultural, multi lingual and multi ethnic country and Buddhists are the predominant ethnic group, constitutes 70.19%  of total population and the Muslims are second largest minority in this country. There are enormous records in the history to prove well the cordial relationship, longer than 1200 years, between the Buddhists and the Muslims since historical times onward. However, in recent past years, particularly, during the aftermath of civil war (1983-2009) it could be observable a tension on the relationship between these two societies. This is because of campaigns undertaken by a few Buddhist nationalist groups with the purpose of making a division between the respective societies. So these groups have been carrying protests against the Muslims’ social, cultural and religious aspects such as issuing Halal certification, slaughtering animals for meals, worship places and prayer services and so on. Also, they have disseminated the misinterpretations about the Muslims and their religion-Islam with derogatory speeches among the Buddhist public. Based on the above backdrop, this paper attempts to find the post-tension Buddhists’ relationship with the Muslims through the Buddhists’ point of view with a measure social interaction. According to the result, there is not remarkable fluctuation on the relationship line between the Buddhists and the Muslims, and the Buddhists did not concern the number of social, cultural and religious practices of the Muslims as the barriers of maintaining a better interaction among them. However, almost all of the Buddhists have pointed out here that the animal slaughtering is a mere problematic factor from the Muslims side in maintaining a better interaction with them due to having prohibition according to Buddhism philosophy. Keywords: Post-tension, relationship, Buddhists, Muslims, Sri Lanka

Anti-Muslim campaign in Sri Lanka and responses of the Buddhists

Sri Lanka is a country where multi ethnic, multi language, multi religious people live. Buddhist is the predominant religious group in Sri Lanka, while the Muslims formed second biggest religious group, next to Tamils. The Buddhist-Muslim relationship has been prevailing and everlastingly for centuries, sbut for a couple of years, a disturbing trend has wide spread, between them. This conflictual nature has come to appear aftermath of the anti-Muslim campaign by few Buddhist Nationalist Groups (BNGs) in Sri Lanka. The basic purpose of the anti-Muslim campaign in Sri Lanka is to propagate bad image of Islam and the Muslims of Sri Lanka, to create a negative perspective among Buddhist public about Islam and Muslims and to distort the good relationship of Buddhists and Muslims in Sri Lanka. In recent past years, few Buddhist Nationalist Groups, campaigned against Halal certification on consumer goods, Hijab of Muslim women, cattle slaughtering, worship places and prayer services in Sri Lanka. Furthermore, they have spread out the idea, that the latest Muslim developments within the country; especially in terms of religion; is a notable threat to Buddhism and to the Buddhist people. These wrong perceptions, ideas and point of views are major factors in Muslim-Buddhist bad relationship, in recent past years. This research attempts to analyze the point of views of few Buddhists, on recent campaigns, against the Muslims, undertaken by the BNGs, in recent past years, by conducting a semi structured interviews in 14 selected Buddhist majority districts of Sri Lanka. Based on the results, it is clearly affirmed that, the recent anti-Muslim campaign, by the BNGs, have created a suspicious nature Muslim stereotype among a group of Buddhists in the society, over a fact that a Buddhist-Muslim relationship in recent past years has damaged a lot. However, these campaigns have not changed the whole Buddhist’s mood and point of views, in terms of maintaining a good relationship with Muslims in Sri Lanka, without any break, as the majority know and respect Muslim citizens of Sri Lanka, because of the behavior and support of Muslims towards the Sri Lankan state, during the civil war (1984-2009) and pre-war time in Sri Lanka

History of Muslims in Monaragala (Wellassa) District, Sri Lanka: Empirical Evidences

Monaragala is one of the 25 administrative districts of Sri Lanka. This district was also named as Wellassa by its ancient inhabitants. It is located in the Uva Province in the South Eastern region of Sri Lanka.  In Monaragala the Sinhalese are the dominant ethnic group as they constitute 94.5% of the total population, the Tamils 3.3% and the Muslims 2.17%. The main objective of this study is to explore the history of the Muslims in Monaragala District. It is an unfilled gap and there is no more academic research on the history of Muslims of Monaragala. Thus, this study takes this gap to be bridged throughout an academic field survey as a qualitative nature of research. In order to carry out this research there has been used the folktales and utterances prevailed among the native public as well as the administrative records and census reports, the ancient tombs and daily used house wares and articles. Based on the finding of this study, the Muslims settled down in Monaragala or Wellassa area during the time of Portuguese rule (1505-1656) from the Central (Kandy) and Southern provinces of Sri Lanka and increased their settlements gradually during the Dutch (1656-1796) and British regimes (1796-1948). Keywords: History, Muslims, Monaragala District, Wellassa, Sri Lank

The nonlinear equation system approach to solving dynamic user optimal simultaneous route and departure time choice problems

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Integration of airborne and ground observations of nitryl chloride in the Seoul metropolitan area and the implications on regional oxidation capacity during KORUS-AQ 2016

Nitryl chloride (ClNO2) is a radical reservoir species that releases chlorine radicals upon photolysis. An integrated analysis of the impact of ClNO2 on regional photochemistry in the Seoul metropolitan area (SMA) during the Korea-United States Air Quality Study (KORUS-AQ) 2016 field campaign is presented. Comprehensive multiplatform observations were conducted aboard the NASA DC-8 and at two ground sites (Olympic Park, OP; Taehwa Research Forest, TRF), representing an urbanized area and a forested suburban region, respectively. Positive correlations between daytime Cl2 and ClNO2 were observed at both sites, the slope of which was dependent on O3 levels. The possible mechanisms are explored through box model simulations constrained with observations. The overall diurnal variations in ClNO2 at both sites appeared similar but the nighttime variations were systematically different. For about half of the observation days at the OP site the level of ClNO2 increased at sunset but rapidly decreased at around midnight. On the other hand, high levels were observed throughout the night at the TRF site. Significant levels of ClNO2 were observed at both sites for 4-5 h after sunrise. Airborne observations, box model calculations, and back-trajectory analysis consistently show that these high levels of ClNO2 in the morning are likely from vertical or horizontal transport of air masses from the west. Box model results show that chlorine-radical-initiated chemistry can impact the regional photochemistry by elevating net chemical production rates of ozone by 25% in the morning

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1.

BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1, GSTM1and GSTT1, that code for drug-metabolizing enzymes. This study evaluated whether the polymorphisms in these enzymes were associated with an increased risk of anti-TB drug-induced hepatitis in patients and could potentially be used to identify patients at risk of liver injury. METHODS AND DESIGN: In a cross-sectional study, 2244 tuberculosis patients were assessed two months after the start of treatment. Anti-TB drug-induced liver injury (ATLI) was defined as an ALT, AST or bilirubin value more than twice the upper limit of normal. NAT2, CYP2E1, GSTM1 and GSTT1 genotypes were determined using the PCR/ligase detection reaction assays. RESULTS: 2244 patients were evaluated, there were 89 cases of ATLI, a prevalence of 4% 9 patients (0.4%) had ALT levels more than 5 times the upper limit of normal. The prevalence of ATLI was greater among men than women, and there was a weak association with NAT2*5 genotypes, with ATLI more common among patients with the NAT2*5*CT genotype. The sensitivity of the CT genotype for identifying patients with ATLI was 42% and the positive predictive value 5.9%. CT ATLI was more common among slow acetylators (prevalence ratio 2.0 (95% CI 0.95,4.20) )compared to rapid acetylators. There was no evidence that ATLI was associated with CYP2E1 RsaIc1/c1genotype, CYP2E1 RsaIc1/c2 or c2/c2 genotypes, or GSTM1/GSTT1 null genotypes. CONCLUSIONS: In Xinjiang Uyghur TB patients, liver injury was associated with the genetic variant NAT2*5, however the genetic markers studied are unlikely to be useful for screening patients due to the low sensitivity and low positive predictive values for identifying persons at risk of liver injury

Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis

Extracellular-signal regulated kinase (ERK) activation by MEK plays a key role in many of the cellular processes that underlie progressive kidney fibrosis including cell proliferation, apoptosis and transforming growth factor β1-mediated epithelial to mesenchymal transition. We therefore assessed the therapeutic impact of ERK1/2 inhibition using a MEK inhibitor in the rat 5/6 subtotal nephrectomy (SNx) model of kidney fibrosis. There was a twentyfold upregulation in phospho-ERK1/2 expression in the kidney after SNx in Male Wistar rats. Rats undergoing SNx became hypertensive, proteinuric and developed progressive kidney failure with reduced creatinine clearance. Treatment with the MEK inhibitor, CI-1040 abolished phospho- ERK1/2 expression in kidney tissue and prevented phospho-ERK1/2 expression in peripheral lymphocytes during the entire course of therapy. CI-1040 had no impact on creatinine clearance, proteinuria, glomerular and tubular fibrosis, and α-smooth muscle actin expression. However, inhibition of ERK1/2 activation led to significant compensatory upregulation of the MAP kinases, p38 and JNK in kidney tissue. CI-1040 also increased the expression of plasminogen activator inhibitor-1 (PAI-1), a key inhibitor of plasmin-dependent matrix metalloproteinases. Thus inhibition of ERK1/2 activation has no therapeutic effect on kidney fibrosis in SNx possibly due to increased compensatory activation of the p38 and JNK signalling pathways with subsequent upregulation of PAI-1