Continued development of doped-germanium photoconductors for astronomical observations at wavelengths from 30 to 120 micrometers

The development of doped-germanium detectors which have optimized performance in the 30- to 120-mu m wavelength range and are capable of achieving the objectives of the infrared astronomical satellite (IRAS) space mission is discussed. Topics covered include the growth and evaluation of Ge:Ga and Ge:Be crystals, procedures for the fabrication and testing of detectors, irradiance calculations, detector responsivity, and resistance measurements through MOSFET. Test data are presented in graphs and charts

Research program to develop a technology improvement program for closed die forging Final report

Upset forging tests on aluminum and titanium alloys and maraging steel using high temperature die

Prime Factorization in the Duality Computer

We give algorithms to factorize large integers in the duality computer. We provide three duality algorithms for factorization based on a naive factorization method, the Shor algorithm in quantum computing, and the Fermat's method in classical computing. All these algorithms are polynomial in the input size.Comment: 4 page

Count Me In: The dimensions of social inclusion through culture and sport

This study was set up to examine claims made for the ability of cultural projects to promote social inclusion (cultural projects are here taken to include those incorporating sport, the arts, media, heritage and outdoor adventure). This was to be achieved primarily by collecting evidence from a sample of 14 projects selected from some 200 that had volunteered their services. The report to the government’s Social Exclusion Unit (SEU) from the Policy Action Team (PAT10) (1999)2 noted the potential. In his foreword, Chris Smith (then Secretary of State for the Department for Culture Media and Sport (DCMS)) wrote: “… art and sport can not only make a valuable contribution to delivering key outcomes of lower long term unemployment, less crime, better health and better qualifications, but can also help to develop the individual pride, community spirit and capacity for responsibility that enable communities to run regeneration programmes themselves”. Similar statements have followed from other politicians, particularly in the recent Commons debate on sport and social exclusion (22/11/01), and again in the public health debate (13/12/01). However, the PAT 10 report also came to the same conclusion as previous commentators (e.g. Glyptis, 19893; Allison & Coalter, 19964; Long & Sanderson, 19985) that there is little ‘hard’ evidence of the social benefits that accrue

Count Me In: The Dimensions of social inclusion through Culture, Media & Sport (Executive Summary)

This study was set up to examine claims made for the ability of cultural projects to promote social inclusion (cultural projects are here taken to include those incorporating sport, the arts, media, heritage and outdoor adventure). This was to be achieved primarily by collecting evidence from a sample of 14 projects selected from some 200 that had volunteered their services. The report to the government’s Social Exclusion Unit (SEU) from the Policy Action Team (PAT10) (1999) noted the potential. In his foreword, Chris Smith (then Secretary of State for the Department for Culture Media and Sport (DCMS)) wrote: “… art and sport can not only make a valuable contribution to delivering key outcomes of lower long term unemployment, less crime, better health and better qualifications, but can also help to develop the individual pride, community spirit and capacity for responsibility that enable communities to run regeneration programmes themselves”. Similar statements have followed from other politicians, particularly in the recent Commons debate on sport and social exclusion (22/11/01), and again in the public health debate (13/12/01). However, the PAT 10 report also came to the same conclusion as previous commentators (e.g. Glyptis, 19893; Allison & Coalter, 19964; Long & Sanderson, 1998) that there is little ‘hard’ evidence of the social benefits that accrue

Eimeria tenella protein trafficking: differential regulation of secretion versus surface tethering during the life cycle

Eimeria spp. are intracellular parasites that have a major impact on poultry. Effective live vaccines are available and the development of reverse genetic technologies has raised the prospect of using Eimeria spp. as recombinant vectors to express additional immunoprotective antigens. To study the ability of Eimeria to secrete foreign antigens or display them on the surface of the sporozoite, transiently transfected populations of E. tenella expressing the fluorescent protein mCherry, linked to endogenous signal peptide (SP) and glycophosphatidylinositol-anchor (GPI) sequences, were examined. The SP from microneme protein EtMIC2 (SP2) allowed efficient trafficking of mCherry to cytoplasmic vesicles and following the C-terminal addition of a GPI-anchor (from surface antigen EtSAG1) mCherry was expressed on the sporozoite surface. In stable transgenic populations, mCherry fused to SP2 was secreted into the sporocyst cavity of the oocysts and after excystation, secretion was detected in culture supernatants but not into the parasitophorous vacuole after invasion. When the GPI was incorporated, mCherry was observed on the sporozites surface and in the supernatant of invading sporozoites. The proven secretion and surface exposure of mCherry suggests that antigen fusions with SP2 and GPI of EtSAG1 may be promising candidates to examine induction of protective immunity against heterologous pathogens

A single-photon sampling architecture for solid-state imaging

Advances in solid-state technology have enabled the development of silicon photomultiplier sensor arrays capable of sensing individual photons. Combined with high-frequency time-to-digital converters (TDCs), this technology opens up the prospect of sensors capable of recording with high accuracy both the time and location of each detected photon. Such a capability could lead to significant improvements in imaging accuracy, especially for applications operating with low photon fluxes such as LiDAR and positron emission tomography. The demands placed on on-chip readout circuitry imposes stringent trade-offs between fill factor and spatio-temporal resolution, causing many contemporary designs to severely underutilize the technology's full potential. Concentrating on the low photon flux setting, this paper leverages results from group testing and proposes an architecture for a highly efficient readout of pixels using only a small number of TDCs, thereby also reducing both cost and power consumption. The design relies on a multiplexing technique based on binary interconnection matrices. We provide optimized instances of these matrices for various sensor parameters and give explicit upper and lower bounds on the number of TDCs required to uniquely decode a given maximum number of simultaneous photon arrivals. To illustrate the strength of the proposed architecture, we note a typical digitization result of a 120x120 photodiode sensor on a 30um x 30um pitch with a 40ps time resolution and an estimated fill factor of approximately 70%, using only 161 TDCs. The design guarantees registration and unique recovery of up to 4 simultaneous photon arrivals using a fast decoding algorithm. In a series of realistic simulations of scintillation events in clinical positron emission tomography the design was able to recover the spatio-temporal location of 98.6% of all photons that caused pixel firings.Comment: 24 pages, 3 figures, 5 table