5,299 research outputs found
Monitoring of tritium purity during long-term circulation in the KATRIN test experiment LOOPINO using laser Raman spectroscopy
The gas circulation loop LOOPINO has been set up and commissioned at Tritium
Laboratory Karlsruhe (TLK) to perform Raman measurements of circulating tritium
mixtures under conditions similar to the inner loop system of the neutrino-mass
experiment KATRIN, which is currently under construction. A custom-made
interface is used to connect the tritium containing measurement cell, located
inside a glove box, with the Raman setup standing on the outside. A tritium
sample (purity > 95%, 20 kPa total pressure) was circulated in LOOPINO for more
than three weeks with a total throughput of 770 g of tritium. Compositional
changes in the sample and the formation of tritiated and deuterated methanes
CT_(4-n)X_n (X=H,D; n=0,1) were observed. Both effects are caused by hydrogen
isotope exchange reactions and gas-wall interactions, due to tritium {\beta}
decay. A precision of 0.1% was achieved for the monitoring of the T_2
Q_1-branch, which fulfills the requirements for the KATRIN experiment and
demonstrates the feasibility of high-precision Raman measurements with tritium
inside a glove box
Statistical analysis plan for the proactive healthcare of older people in care homes (PEACH) study
The Proactive Healthcare for Older People living in Care Homes (PEACH) study aims to
evaluate whether Quality Improvement Collaboratives can be an effective way to work
with local health and social care stakeholders, including representatives of the care home
sector, to implement Comprehensive Geriatric Assessment (CGA) in the care home
setting. It will enlist the support of four Area Improvement Collaboratives from South
Nottinghamshire, UK to make changes to enable CGA in care homes in their areas.
The primary outcome measure is health-related quality of life (HRQoL), measured using
the EuroQoL 5-domain 5-level (EQ-5D-5L) index. A cluster-randomised (where care
homes represent clusters) approach will be taken. Secondary outcome measures will be
Health Service Resource by service category. These will be analysed using an
interrupted time series approach.
The methodology is challenging and introduces the need to control for multiple sources
of contamination, clustering, time effects including lag effect and measurement issues
with the primary outcome variable, including the uncertain reliability of care home staff
proxy responses.
This paper outlines the statistical analysis plan for the study, describing how these
challenges have been addressed. It acts as reference point for further publications from
the PEACH study
SandflyMap: leveraging spatial data on sand fly vector distribution for disease risk assessments
We feature SandflyMap (www.sandflymap.org), a new map service within VectorMap (www.vectormap.org) that allows free public online access to global sand fly, tick and mosquito collection records and habitat suitability models. Given the short home range of sand flies, combining remote sensing and collection point data give a powerful insight into the environmental determinants of sand fly distribution. SandflyMap is aimed at medical entomologists, vector disease control workers, public health officials and health planners. Data are checked for geographical and taxonomic errors, and are comprised of vouchered specimen information, and both published and unpublished observation data. SandflyMap uses Microsoft Silverlight and ESRIâs ArcGIS Server 10 software platform to present disease vector data and relevant remote sensing layers in an online geographical information system format. Users can view the locations of past vector collections and the results
of models that predict the geographic extent of individual species. Collection records are searchable and downloadable, and Excel collection forms with drop down lists, and Excel charts to country, are available for data contributors to map and quality control their data. SandflyMap makes accessible, and adds value to, the results of past sand fly collecting efforts. We detail the workflow for entering occurrence data from the literature to SandflyMap, using an example for sand flies from South America. We discuss the utility of SandflyMap as a focal point to increase collaboration and to explore the nexus between geography and vector-borne disease transmission
Whatâs so bad about scientism?
In their attempt to defend philosophy from accusations of uselessness made by prominent scientists, such as Stephen Hawking, some philosophers respond with the charge of âscientism.â This charge makes endorsing a scientistic stance, a mistake by definition. For this reason, it begs the question against these critics of philosophy, or anyone who is inclined to endorse a scientistic stance, and turns the scientism debate into a verbal dispute. In this paper, I propose a different definition of scientism, and thus a new way of looking at the scientism debate. Those philosophers who seek to defend philosophy against accusations of uselessness would do philosophy a much better service, I submit, if they were to engage with the definition of scientism put forth in this paper, rather than simply make it analytic that scientism is a mistake
Measuring health related quality of life of care home residents, comparison of self-report with staff proxy responses for EQ-5D-5L and HowRu: protocol for assessing proxy reliability in care home outcome testing
Introduction
Research into interventions to improve health and wellbeing for older people living in care homes is increasingly common. Health-Related Quality of Life (HRQoL) is frequently used as an outcome measure but collecting both self-reported and proxy HRQoL measures is challenging in this setting. This study will investigate the reliability of UK care home staff as proxy respondents for the EQ-5D-5L and HowRu measures.
Methods and Analysis
This is a prospective cohort study of a sub-population of care home residents recruited to the larger Proactive Healthcare for Older People in Care Homes (PEACH) study. It will recruit residents â„ 60 years across 24 care homes and not receiving short stay or respite care. The sample size is 160 participants. Resident and care home staff proxy EQ-5D-5L and HowRu responses will be collected monthly for three months. Weighted kappa statistics and intraclass correlation adjusted for clustering at the care home level will be used to measure agreement between resident and proxy responses. The extent to which staff variables (gender, age group, length of time caring, role, how well they know the resident, length of time working in care homes and in specialist gerontological practice) influence the level of agreement between self-reported and proxy responses will be considered using a multilevel mixed-effect regression model.
Ethics and Dissemination
The PEACH study protocol was reviewed by the UK Health Research Authority and University of Nottingham Research Ethics Committee and was determined to be a service development project. We will publish this study in a peer-reviewed journal with international readership and disseminate it through relevant national stakeholder networks and specialist societies
Discrete symmetries, invisible axion and lepton number symmetry in an economic 3-3-1 model
We show that Peccei-Quinn and lepton number symmetries can be a natural
outcome in a 3-3-1 model with right-handed neutrinos after imposing a Z_11 x
Z_2 symmetry. This symmetry is suitably accommodated in this model when we
augmented its spectrum by including merely one singlet scalar field. We work
out the breaking of the Peccei-Quinn symmetry, yielding the axion, and study
the phenomenological consequences. The main result of this work is that the
solution to the strong CP problem can be implemented in a natural way, implying
an invisible axion phenomenologically unconstrained, free of domain wall
formation and constituting a good candidate for the cold dark matter.Comment: 17 pages, Revtex
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