4,873 research outputs found
The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters.
DNA sequence signals in the core promoter, such as the initiator (Inr), direct transcription initiation by RNA polymerase II. Here we show that the human Inr has the consensus of BBCA+1BW at focused promoters in which transcription initiates at a single site or a narrow cluster of sites. The analysis of 7678 focused transcription start sites revealed 40% with a perfect match to the Inr and 16% with a single mismatch outside of the CA+1 core. TATA-like sequences are underrepresented in Inr promoters. This consensus is a key component of the DNA sequence rules that specify transcription initiation in humans
Characterization of damage in shielding structures of space vehicles under hypervelocity impact
6th Asia Pacific Workshop on Structural Health Monitoring, APWSHM, Hobart, Tasmania, Australia, 7-9 December 2016Version of RecordPublishe
Matching Temporal Signatures of Solar Features to Their Corresponding Solar-Wind Outflows
The role of small-scale coronal eruptive phenomena in the generation and heating of the solar wind remains an open question. Here, we investigate the role played by coronal jets in forming the solar wind by testing whether temporal variations associated with jetting in EUV intensity can be identified in the outflowing solar-wind plasma. This type of comparison is challenging due to inherent differences between remote-sensing observations of the source and in-situ observations of the outflowing plasma, as well as travel time and evolution of the solar wind throughout the heliosphere. To overcome these, we propose a novel algorithm combining signal filtering, two-step solar-wind ballistic back-mapping, window shifting, and Empirical Mode Decomposition. We first validate the method using synthetic data, before applying it to measurements from the Solar Dynamics Observatory and Wind spacecraft. The algorithm enables the direct comparison of remote-sensing observations of eruptive phenomena in the corona to in-situ measurements of solar-wind parameters, among other potential uses. After application to these datasets, we find several time windows where signatures of dynamics found in the corona are embedded in the solar-wind stream, at a time significantly earlier than expected from simple ballistic back-mapping, with the best-performing in-situ parameter being the solar-wind mass flux
Active Region Modulation of Coronal Hole Solar Wind
Active regions (ARs) are a candidate source of the slow solar wind (SW), the origins of which are a topic of ongoing research. We present a case study that examines the processes by which SW is modulated in the presence of an AR in the vicinity of the SW source. We compare properties of SW associated with a coronal hole (CH)–quiet Sun boundary to SW associated with the same CH but one Carrington rotation later, when this region bordered the newly emerged NOAA AR 12532. Differences found in a range of in situ parameters are compared between these rotations in the context of source region mapping and remote sensing observations. Marked changes exist in the structure and composition of the SW, which we attribute to the influence of the AR on SW production from the CH boundary. These unique observations suggest that the features that emerge in the AR-associated wind are consistent with an increased occurrence of interchange reconnection during SW production, compared with the initial quiet Sun case
Characterizing hypervelocity impact (HVI)-induced pitting damage using active guided ultrasonic waves : from linear to nonlinear
2016-2017 > Academic research: refereed > Publication in refereed journal201804_a bcmaVersion of RecordPublishe
Scaling behaviour in spherical shell rotating convection with fixed-flux thermal boundary conditions
Bottom-heated convection in rotating spherical shells provides a simple analogue for many astrophysical and geophysical fluid systems. We construct a database of 74 three-dimensional numerical convection models to investigate the scaling behaviour of seven diagnostics over a range of Ekman and Rayleigh numbers while using a Prandtl number of unity. Our configuration is chosen to model Earth’s core as defined by the fixed flux thermal boundary conditions, radius ratio of and a gravity profile that varies linearly with radius. The quantities of interest are the viscous and thermal boundary layer thickness, mean temperature gradient, mean interior temperature, Nusselt number, horizontal flow length scale, and Reynolds number. We find four parameter regimes characterised by different scaling behaviour. For and low the weakly nonlinear regime is characterised by a balance between viscous, Archimedean and Coriolis forces and the heat transfer is described by weakly nonlinear theory. At low and moderate , the rapidly rotating regime sees inertia take over from viscosity in the global force balance. In this regime the heat transfer scaling has increasing exponent with decreasing Ekman number and shows no saturation to the diffusion free scaling. At high and all the importance of the Coriolis force gradually decreases and all diagnostics continually change in the transitional regime before approaching the scaling behaviour of non-rotating convection
Thermal boundary layer structure in convection with and without rotation
Convection occurs in many settings from metal production to planetary interiors and atmospheres. To understand the dynamics of these systems it is vital to be able to predict the heat transport which is controlled by the thermal boundary layers (TBL). An important issue in the study of convective fluid dynamics is then to determine the temperature distribution within these thin layers in the vicinity of the bounding walls. Deviations from the classical Rayleigh-Bénard convection paradigm such as the addition of rotation or fixed heat-flux (rather than fixed temperature) boundaries compromise the standard ways of defining the width of the TBL. We propose an alternative method for defining the TBL using the location at which the advective and conductive contributions to the heat transport become equal. We show that this method can be robustly applied to two-dimensional (2D) nonrotating convection between no-slip boundaries with fixed temperature or fixed heat-flux thermal boundary conditions and three-dimensional (3D) rotating convection simulations with free-slip boundaries
Integration of airborne and ground observations of nitryl chloride in the Seoul metropolitan area and the implications on regional oxidation capacity during KORUS-AQ 2016
Nitryl chloride (ClNO2) is a radical reservoir species that releases chlorine radicals upon photolysis. An integrated analysis of the impact of ClNO2 on regional photochemistry in the Seoul metropolitan area (SMA) during the Korea-United States Air Quality Study (KORUS-AQ) 2016 field campaign is presented. Comprehensive multiplatform observations were conducted aboard the NASA DC-8 and at two ground sites (Olympic Park, OP; Taehwa Research Forest, TRF), representing an urbanized area and a forested suburban region, respectively. Positive correlations between daytime Cl2 and ClNO2 were observed at both sites, the slope of which was dependent on O3 levels. The possible mechanisms are explored through box model simulations constrained with observations. The overall diurnal variations in ClNO2 at both sites appeared similar but the nighttime variations were systematically different. For about half of the observation days at the OP site the level of ClNO2 increased at sunset but rapidly decreased at around midnight. On the other hand, high levels were observed throughout the night at the TRF site. Significant levels of ClNO2 were observed at both sites for 4-5 h after sunrise. Airborne observations, box model calculations, and back-trajectory analysis consistently show that these high levels of ClNO2 in the morning are likely from vertical or horizontal transport of air masses from the west. Box model results show that chlorine-radical-initiated chemistry can impact the regional photochemistry by elevating net chemical production rates of ozone by 25% in the morning
Using the theory of planned behaviour as a process evaluation tool in randomised trials of knowledge translation strategies : A case study from UK primary care
Peer reviewedPublisher PD
First shark from the late Devonian (Frasnian) gogo formation, Western Australia sheds new light on the development of tessellated calcified cartilage
Background: Living gnathostomes (jawed vertebrates) comprise two divisions, Chondrichthyes (cartilaginous fishes, including euchondrichthyans with prismatic calcified cartilage, and extinct stem chondrichthyans) and Osteichthyes (bony fishes including tetrapods). Most of the early chondrichthyan (‘shark’) record is based upon isolated teeth, spines, and scales, with the oldest articulated sharks that exhibit major diagnostic characters of the group—prismatic calcified cartilage and pelvic claspers in males—being from the latest Devonian, c. 360 Mya. This paucity of information about early chondrichthyan anatomy is mainly due to their lack of endoskeletal bone and consequent low preservation potential. Methodology/Principal Findings: Here we present new data from the first well-preserved chondrichthyan fossil from the early Late Devonian (ca. 380–384 Mya) Gogo Formation Lägerstatte of Western Australia. The specimen is the first Devonian shark body fossil to be acid-prepared, revealing the endoskeletal elements as three-dimensional undistorted units: Meckel’s cartilages, nasal, ceratohyal, basibranchial and possible epibranchial cartilages, plus left and right scapulocoracoids, as well as teeth and scales. This unique specimen is assigned to Gogoselachus lynnbeazleyae n. gen. n. sp.Conclusions/Significance: The Meckel’s cartilages show a jaw articulation surface dominated by an expansive cotylus, and a small mandibular knob, an unusual condition for chondrichthyans. The scapulocoracoid of the new specimen shows evidence of two pectoral fin basal articulation facets, differing from the standard condition for early gnathostomes which have either one or three articulations. The tooth structure is intermediate between the ‘primitive’ ctenacanthiform and symmoriiform condition, and more derived forms with a euselachian-type base. Of special interest is the highly distinctive type of calcified cartilage forming the endoskeleton, comprising multiple layers of nonprismatic subpolygonal tesserae separated by a cellular matrix, interpreted as a transitional step toward the tessellated prismatic calcified cartilage that is recognized as the main diagnostic character of the chondrichthyans
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