La contraffazione dei farmaci e il commercio dei medicinali su Internet: questioni emergenti, aspetti regolatori, percezione e atteggiamento di operatori e utenti.

The first part of this research focuses on drug counterfeiting and trade on the Internet in Europe and in Italy in several respects: definition, scale of the problem, examples and alerts, Interpol and Impact; counterfeiting of medicines and Italian legislation, economic implications, criminal activities; European legislation; shortage of drugs and possible purchase online; Impact Italy; tracking of the drug; contrasting efforts. In the second part, the results of a series of surveys concerning online purchase of drugs and knowledge and opinions about the internet as a source of medical information and medicine supply. In a survey via computer, several web sites offering anabolic androgenic steroids and available products were identified and analysed for their content. In a questionnaire survey among a large sample of pharmacy customers we evaluated the attitudes towards the use of Internet to retrieve health-related information and for drugs and/or dietary supplements purchase. Finally, the views of pharmacists on the sale of drugs and parapharmaceutical products on the Internet were suveyed by means of an online questionnaire and their attitudes towards online pharmacies were investigated. In conclusion, it is suggested that the web should be considered not only a source of danger but also of opportunities for the retrieval of health-related information as well as for the availability of medicines, however several measures need to be taken to ensure its safety and reliability

Seismic site response in Siracusa

In the frame of the Italo–Maltese research project (Costituzione di un Sistema Integrato di Protezione Civile Transfrontaliero Italo–Maltese, SIMIT), researches financially supported by the European Community were performed in the area between the south–eastern Sicilian coast and the islands of Lampedusa and Malta. Aim of these stud- ies is to mitigate natural hazards and to develop the geological and geophysical information in the investigated region. The damage to buildings further to a seismic input is tightly linked, besides their vulnerability, to both the characteristics of the maximum acceleration and frequency of the ground motion, as well as to the features of surface geology. From this point of view, the geophysical and geotechnical characterization of the soil conditions, down to the bedrock, is very important in order to identify the site effects, in terms of fundamental frequencies, for a correct planning of earthquake resistant structures.peer-reviewe

Dentoskeletal effects of the bitejumping appliance and the twin-block appliance in the treatment of skeletal class ii malocclusion: A retrospective controlled clinical trial

The current retrospective controlled trial aimed to compare the dentoskeletal effects of the Bite-Jumping (BJ) and the Twin- Block Appliance (TB) in the treatment of skeletal Class II malocclusion. The sample was screened for eligibility criteria including skeletal and dental Class II malocclusion; Cervical Vertebral Maturation at Stage 3 at treatment start, and Func- tional orthopedic treatment with either a TB or BJ appliances. Twenty-three patients treated with TB, and twenty-three treated with BJ were included. Cephalometric data were compared with a control group of 15 untreated subjects retrieved from the American Association of Orthodontists Foundation Craniofacial Growth Legacy Collection. Baseline character- istics were similar between groups. A significant increase for the AO-BO dimension, and a significant decrease in the over- jet, were registered for both study groups respect to controls. TB was more effective than BJ in increasing the mandibu- lar length (Co-Gn), in reducing the ANB angle and changing the SNB angle. The resulting differences between the two groups could be attributed to the different appliances. In conclusion, both appliances demonstrated a clinical efficacy in treating Class II. TB seems therefore better indicated, respect to BJ, in Class II cases with a predominant component of mandibular hypoplasia

Hyperhomocysteinemia and C677T MTHFR genotype in patients with retinal vein thrombosis.

Introduction: Elevated homocysteine (Hcy) is associated with the risk of deep vein thrombosis, pulmonary embolism, ischemic heart disease, and stroke. Several studies have suggested that hyperhomocysteinemia (HHcy) may predispose to retinal vein thrombosis (RVT) development. The aim of this study is to investigate the relationship between Hcy, C677T methylenetetrahydrofolate reductase (MTHFR) genotype, and RVT in patients compared with controls. Materials and Methods: We evaluated the Hcy plasma level of 3114 consecutive participants in 2 Italian centers during a 2-year period. Hyperhomocysteinemia was found in 99 patients and 136 healthy participants. Of the 99 patients, 20 had RVT with a high prevalence of HHcy in the RVT subgroup (20.2%). This result suggested a possible relationship between HHcy and RVT development. We investigated 105 consecutive patients with recent diagnosis of RVT, and we compared them with 226 healthy controls to evaluate whether HHcy may be a risk factor for RVT. Results: the prevalence of HHcy was higher in patients compared with controls (34.3% vs 14.2%; P < .001). The MTHFR C677T genotype was found in 69 of 105 (65.7%) patients with RVT (heterozygosity: 40 of 105 and homozygosity: 29 of 105). The control group showed the presence of MTHFR C677T genotype in 169 of 226 participants (74.8%; heterozygosity: 100 of 226 and homozygosity: 69 of 226) without difference between the 2 groups (P = .08). Conclusion: our study suggests that HHcy is a possible risk factor for RVT development, while no association was found between RVT and the C677T MTHFR genotype

Curved CMOS sensor: characterization of the first fully functional prototype

Many are the optical designs that generate curved focal planes for which field flattener must be implemented. This generally implies the use of more optical elements and a consequent loss of throughput and performances. With the recent development of curved sensor this can be avoided. This new technology has been gathering more and more attention from a very broad community, as the potential applications are multiple: from low-cost commercial to high impact scientific systems, to mass-market and on board cameras, defense and security, and astronomical community. We describe here the first concave curved CMOS detector developed within a collaboration between CNRS-LAM and CEA-LETI. This fully-functional detector 20Mpix (CMOSIS CMV20000) has been curved down to a radius of R_c =150mm over a size of 24x32mm^2. We present here the methodology adopted for its characterization and describe in detail all the results obtained. We also discuss the main components of noise, such as the readout noise, the fixed pattern noise and the dark current. Finally we provide a comparison with the at version of the same sensor in order to establish the impact of the curving process on the main characteristics of the sensor