228 research outputs found
Capital Punishment Reforms in Illinois: Comparing the Views of Police, Prosecutors, and Public Defenders
On 9 March 2011, Governor Patrick Quinn abolished capital punishment in Illinois stating that the state’s system of imposing the death penalty was inherently flawed. Quinn’s announcement followed an eleven-year effort to end the death penalty that began with a 2000 moratorium on executions imposed by then Governor George Ryan. This moratorium was the direct result of the appellate reversal of a series of death-row convictions. Prompted by these reversals, Ryan also created the Governor’s Commission on Capital Punishment to study the use of the death penalty in Illinois. As a result of this effort, comprehensive legislation was enacted to reform the Illinois death penalty system, and the Capital Punishment Reform Study Committee was formed to gauge the implementation and impact of the reforms. Working with the Committee, the authors’ surveyed 413 Illinois police departments, 102 Illinois State’s Attorneys’ Offices, and all 99 Public Defender’s Offices in an effort to determine the extent to which criminal justice agencies had implemented the requirements of the capital punishment reform legislation, and whether there were any significant barriers to the implementation of the legislative requirements. This paper reports the results of this inquiry, and argues that capital punishment ended in Illinois because of the complexity of the death penalty and the perceived inability to devise a system free of racial, geographic, and economic bias and not the failure of the criminal justice community to implement the reforms recommended by the Governor’s Commission on Capital Punishment
Can Community Policing Increase Residents\u27 Informal Social Control? Testing the Impact of the Chicago Alternative Policing Strategy
This study examines whether community policing can build informal social control. Specifically, this paper assesses the impact of the Chicago Alternative Policing Strategy (CAPS) in Chicago neighborhoods. The data for this research are drawn from both the Community Survey of the Project on Human Development in Chicago Neighborhoods (PHDCN) and the CAPS Prototype Panel Survey. Bivariate and multivariate methods are used to analyze data gathered from 8782 residents nested within 343 neighborhood clusters. Initially, community policing was found to increase informal social control, but this effect was rendered non-significant after controlling for theoretically and empirically relevant variables. Several social (dis)organization variables, as well as satisfaction with policing services, yielded significant effects in a multilevel regression model. Further analysis found that the community policing effect on informal social control was mediated through satisfaction with the police. These findings indicate indirect support for the ability of community policing to build informal social control and suggest that general satisfaction with the police is important to neighborhood crime control strategies
Dense Quarks, and the Fermion Sign Problem, in a SU(N) Matrix Model
We study the effect of dense quarks in a SU(N) matrix model of deconfinement.
For three or more colors, the quark contribution to the loop potential is
complex. After adding the charge conjugate loop, the measure of the matrix
integral is real, but not positive definite. In a matrix model, quarks act like
a background Z(N) field; at nonzero density, the background field also has an
imaginary part, proportional to the imaginary part of the loop. Consequently,
while the expectation values of the loop and its complex conjugate are both
real, they are not equal. These results suggest a possible approach to the
fermion sign problem in lattice QCD.Comment: 9 pages, 3 figure
Organizational Approaches to Drug Law Enforcement by Local Police Departments in the United States: Specialized Drug Units and Participation in Multi-Agency Drug Task Forces
This paper examines the factors associated with the decision of local police departments in the United States to operate specialized drug units or to participate in multi-jurisdictional drug task forces. Combining data from the Law Enforcement Management and Administrative Statistics (LEMAS) Survey, the 2000 Census, and the Uniform Crime Report, we use both bivariate and multivariate methods to conduct the analysis. The findings indicate that county-level agencies, those with other formalized drug control efforts, high levels of violent crime, high degrees of task specialization and formalization, and high proportions of the resident population accounted for by renters were more likely to operate drug units, participate in multi-agency drug task forces, and allocate more officers per capita to these efforts
The Forty-Two Gang: The Unpublished Landesco Manuscripts
This paper examines Chicago\u27s Forty-Two Gang. The Forty-Two Gang is one of the most famous groups in gang history, yet we know very little about the gang. Combining data from published and archival sources, this paper provides a history of the gang and explores its impact on the emergence of the Outfit, the traditional organized crime group in Chicago. The archival sources used in this analysis come from the unpublished John Landesco manuscript collection. The manuscripts not only provide a rich source of information on the Forty-Two Gang, but also a fresh look at the diffusion of delinquency subcultures and female participation in gang life during the early years of the twentieth century
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Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.
Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but traditionally intractable drug target. Here we provide genetic and pharmacological evidence that in preclinical models ACC is required to maintain the de novo fatty acid synthesis needed for growth and viability of non-small-cell lung cancer (NSCLC) cells. We describe the ability of ND-646-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC. These findings demonstrate that ACC mediates a metabolic liability of NSCLC and that ACC inhibition by ND-646 is detrimental to NSCLC growth, supporting further examination of the use of ACC inhibitors in oncology
Outcomes and risk score for distal pancreatectomy with celiac axis resection (DP-CAR) : an international multicenter analysis
Background: Distal pancreatectomy with celiac axis resection (DP-CAR) is a treatment option for selected patients with pancreatic cancer involving the celiac axis. A recent multicenter European study reported a 90-day mortality rate of 16%, highlighting the importance of patient selection. The authors constructed a risk score to predict 90-day mortality and assessed oncologic outcomes.
Methods: This multicenter retrospective cohort study investigated patients undergoing DP-CAR at 20 European centers from 12 countries (model design 2000-2016) and three very-high-volume international centers in the United States and Japan (model validation 2004-2017). The area under receiver operator curve (AUC) and calibration plots were used for validation of the 90-day mortality risk model. Secondary outcomes included resection margin status, adjuvant therapy, and survival.
Results: For 191 DP-CAR patients, the 90-day mortality rate was 5.5% (95 confidence interval [CI], 2.2-11%) at 5 high-volume (1 DP-CAR/year) and 18% (95 CI, 9-30%) at 18 low-volume DP-CAR centers (P=0.015). A risk score with age, sex, body mass index (BMI), American Society of Anesthesiologists (ASA) score, multivisceral resection, open versus minimally invasive surgery, and low- versus high-volume center performed well in both the design and validation cohorts (AUC, 0.79 vs 0.74; P=0.642). For 174 patients with pancreatic ductal adenocarcinoma, the R0 resection rate was 60%, neoadjuvant and adjuvant therapies were applied for respectively 69% and 67% of the patients, and the median overall survival period was 19months (95 CI, 15-25months).
Conclusions: When performed for selected patients at high-volume centers, DP-CAR is associated with acceptable 90-day mortality and overall survival. The authors propose a 90-day mortality risk score to improve patient selection and outcomes, with DP-CAR volume as the dominant predictor
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