Deep H-band Galaxy Counts and Half-light Radii from HST/NICMOS Parallel Observations

We present deep galaxy counts and half-light radii from F160W ($\lambda_c=1.6\mu$) images obtained with NICMOS on HST. Nearly 9 arcmin$^2$ have been imaged with camera 3, with $3\sigma$ depths ranging from H = 24.3 to 25.5 in a 0.6$''$ diameter aperture. The slope of the counts fainter than H~$= 20$ is 0.31, and the integrated surface density to H$\leq 24.75$ is $4 \times 10^5$ galaxies per square degree. The half-light radii of the galaxies declines steeply with apparent magnitude. At H~$=24$ we are limited by both the delivered FWHM and the detection threshold of the images.Comment: 8 pages. Accepted for publication in ApJ Letter

The ASCC2 CUE domain in the ALKBH3-ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin

Alkylation of DNA and RNA is a potentially toxic lesion that can result in mutations and even cell death. In response to alkylation damage, K63-linked polyubiquitin chains are assembled that localize the Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3-Activating Signal Cointegrator 1 Complex Subunit (ASCC) repair complex to damage sites in the nucleus. The protein ASCC2, a subunit of the ASCC complex, selectively binds K63-linked polyubiquitin chains via its coupling of ubiquitin conjugation to ER degradation (CUE) domain. The basis for polyubiquitin-binding specificity was unclear, because CUE domains in other proteins typically bind a single ubiquitin and do not discriminate among different polyubiquitin linkage types. We report here that the ASCC2 CUE domain selectively binds K63-linked diubiquitin by contacting both the distal and proximal ubiquitin. The ASCC2 CUE domain binds the distal ubiquitin in a manner similar to that reported for other CUE domains bound to a single ubiquitin, whereas the contacts with the proximal ubiquitin are unique to ASCC2. Residues in the N-terminal portion of the ASCC2 α1 helix contribute to the binding interaction with the proximal ubiquitin of K63-linked diubiquitin. Mutation of residues within the N-terminal portion of the ASCC2 α1 helix decreases ASCC2 recruitment in response to DNA alkylation, supporting the functional significance of these interactions during the alkylation damage response. Our study reveals the versatility of CUE domains in ubiquitin recognition

Deep H-Band Galaxy Counts and Half-Light Radii from Hubble Space Telescope/NICMOS Parallel Observations

We present deep galaxy counts and half-light radii from F160W (λ_c=1.6 μm) images obtained with the Near-Infrared Camera and Multiobject Spectrograph on the Hubble Space Telescope. Nearly 9 arcmin^2 have been imaged with camera 3, with 3 σ depths ranging from H=24.3 to 25.5 in a 0."6 diameter aperture. The slope of the counts fainter than H = 20 is 0.31, and the integrated surface density to H ≤ 24.75 is 4×10^5 galaxies deg^(-2). The half-light radii of the galaxies decline steeply with apparent magnitude. At H = 24, we are limited by both the delivered FWHM and the detection threshold of the images

Measuring the Effect of a Resuscitation Academy on Out of Hospital Cardiac Arrest Resuscitation Rates

According to the American Heart Association (AHA), rates of successful resuscitation after out of hospital cardiac arrest (OHCA) vary across the country. Amongst 132 counties in the United States, the rates of CPR survival to hospital discharge ranges between 3.4%-22.0%, and the rates of CPR survival with functional recovery ranges from 0.8%-20.1%. This large degree of variability between regions has been improved through programs that educate Emergency Medical Service (EMS) departments on ways to improve outcomes through an evidence-based lens. The Medic One EMS department in Seattle and King County, Washington developed a resuscitation academy (RA) that improved cardiac arrest survival from 26% in 2002 to 62% in 2013. In 2015, The New Castle County, Delaware EMS (NCCEMS) department modeled a RA after the Medic One EMS department. This study measured the effect on the number of patients experiencing return of spontaneous circulation (ROSC) and the cerebral performance category (CPC) scores for discharged patients. Data from 599 atraumatic out-of-hospital cardiac arrests (OHCA) was collected from 2009-2019, and 99 cases met Utstein inclusion criteria. Next, the study categorized if at least one RA was implemented prior to these cases to determine the RA’s effect. Implementation of one RA on ROSC outcomes yielded a significant improvement (p = .028), with a small to medium strength of effect (Cramer’s V=0.221); this indicates that the administration of at least one RA had a moderate and significant effect on increasing ROSC in patients suffering from OHCA. Administration of at least one RA did not demonstrate a significant effect on eventual patient outcomes as indicated by discharge CPC score (p = .488). This indicates that there was no statistically significant effect on the cerebral performance of patients who suffered OHCA upon discharge

Gravidezes subseqüentes: quem as tem e quem as quer? Observações em um centro urbano da região Sul do Brasil

Em um estudo de coorte de base populacional, foram estudados todos os 6.011 nascimentos hospitalares ocorridos na cidade de Pelotas, RS, em 1982. As parturientes foram entrevistadas logo após o parto, e 80% delas foram novamente contactadas em suas residências no início de 1986, em média 43 meses mais tarde. Dessas mulheres, 39% haviam engravidado novamente. Esta proporção variou inversamente em relação à idade materna, anos de escolaridade e renda familiar. Quanto à paridade, a proporção de gravidezes subsqüentes foi maior para primíparas e para multíparas. Mães cujos filhos nasceram através de cesareana também apresentaram menor fecundidade, mesmo após exclusão daquelas que, por ocasião da operação cesárea, sofreram ligadura de trompas. Análise através de regressão logística mostrou que esses fatores permaneceram significativamente associados à fecundidade mesmo após o ajuste estatístico para as demais variáveis. Das mães que engravidaram após 1982, 60% informaram que não a desejaram. A proporção das gravidezes indesejadas foi mais elevada em mulheres de maior paridade, sendo esta tendência mais marcada em mulheres de famílias de alta renda.Subsequent pregnancies in mothers of a birth cohort from Pelotas, Southern Brazil, were studied in relation to maternal and socio-economic factors. Within about 3 1/2 years of the cohort child's birth, 39% of mothers had experienced at least one further pregnancy. This proportion decreased with increasing maternal age, years of schooling and family income. A U-shaped trend was observed with respect to parity. Mothers who had delivered the cohort child by caesarean section were also less likely to have another pregnancy within that time. Logistic regression analysis showed that each of these factors remained significantly associated with further pregnancies after controlling for the remaining variables. Analysis of the first subsequent pregnancy showed that a high proportion of mothers had not wanted the pregnancy. Unwanted pregnancies were also significantly associated with older women, low educational status, higher parity and low family income

Depois do choque e do pavor: reflexões acerca da Guerra do Iraque

O artigo procura discutir as conseqüências, principalmente econômicas, da Guerra do Iraque. Após algumas considerações acerca das motivações para essa Guerra, as conseqüências dividem-se em três ordens de questões: microeconômicas, macroeconômicas e aquelas envolvendo os organismos multilaterais. Por fim, tecem-se algumas considerações acerca dos impactos dessas conseqüências sobre o Brasil e a América Latina

2007-2008 Mostly Music: Mozart

Hosted by Marshall Turkin and Staging by Jan McArt Presented in cooperation with the Lewis Jewish Community Center Date & Time: Saturday, February 9, 2008 at 7:30 pm and Sunday, February 10, 2008 at 4:00 pmhttps://spiral.lynn.edu/conservatory_mostlymusic/1001/thumbnail.jp

Anomalous Spectral Shift of Near- and Far-Field Plasmonic Resonances in Nanogaps.

The near-field and far-field spectral response of plasmonic systems are often assumed to be identical, due to the lack of methods that can directly compare and correlate both responses under similar environmental conditions. We develop a widely tunable optical technique to probe the near-field resonances within individual plasmonic nanostructures that can be directly compared to the corresponding far-field response. In tightly coupled nanoparticle-on-mirror constructs with nanometer-sized gaps we find >40 meV blue-shifts of the near-field compared to the dark-field scattering peak, which agrees with full electromagnetic simulations. Using a transformation optics approach, we show such shifts arise from the different spectral interference between different gap modes in the near- and far-field. The control and tuning of near-field and far-field responses demonstrated here is of paramount importance in the design of optical nanostructures for field-enhanced spectroscopy, as well as to control near-field activity monitored through the far-field of nano-optical devices.We acknowledge financial support from EPSRC grants EP/G060649/1, EP/L027151/1, EP/G037221/1, EPSRC NanoDTC, and ERC grant LINASS 320503. J.A. acknowledges support from project FIS2013-41184-P from Spanish MINECO and project NANOGUNE'14 from the Dept. of Industry of the Basque Country. F.B. acknowledges support from the Winton Programme for the Physics of Sustainability. R.C. acknowledges financial support from St. John's College, Cambridge for Dr. Manmohan Singh Scholarship. P.A. acknowledges funding from the Helmholtz Association for the Young Investigator group VH-NG-928 within the Initiative and Networking fund. We thank Laurynas Pukenas and Steve Evans (University of Leeds, UK) for support with the ellipsometry measurementsThis is the final version of the article. It first appeared from the American Chemical Society via https://doi.org/10.1021/acsphotonics.5b0070