Quality assurance in stereotactic radiosurgery/radiotherapy according to DIN 6875-1

The new DIN (' Deutsche Industrie- Norm') 6875- 1, which is currently being finalised, deals with quality assurance ( QA) criteria and tests methods for linear accelerator and Gamma Knife stereotactic radiosurgery/ radiotherapy including treatment planning, stereotactic frame and stereotactic imaging and a system test to check the whole chain of uncertainties. Our existing QA program, based on dedicated phantoms and test procedures, has been refined to fulfill the demands of this new DIN. The radiological and mechanical isocentre corresponded within 0.2 mm and the measured 50% isodose lines were in agreement with the calculated ones within less than 0.5 mm. The measured absorbed dose was within 3%. The resultant output factors measured for the 14-, 8- and 4- mm collimator helmet were 0.9870 +/- 0.0086, 0.9578 +/- 0.0057 and 0.8741 +/- 0.0202, respectively. For 170 consecutive tests, the mean geometrical accuracy was 0.48 +/- 0.23 mm. Besides QA phantoms and analysis software developed in- house, the use of commercially available tools facilitated the QA according to the DIN 6875- 1 with which our results complied. Copyright (C) 2004 S. Karger AG, Basel

A survey of cost-sensitive decision tree induction algorithms

The past decade has seen a significant interest on the problem of inducing decision trees that take account of costs of misclassification and costs of acquiring the features used for decision making. This survey identifies over 50 algorithms including approaches that are direct adaptations of accuracy based methods, use genetic algorithms, use anytime methods and utilize boosting and bagging. The survey brings together these different studies and novel approaches to cost-sensitive decision tree learning, provides a useful taxonomy, a historical timeline of how the field has developed and should provide a useful reference point for future research in this field

Ultra-high dose rate dosimetry for pre-clinical experiments with mm-small proton fields.

PURPOSE To characterize an experimental setup for ultra-high dose rate (UHDR) proton irradiations, and to address the challenges of dosimetry in millimetre-small pencil proton beams. METHODS At the PSI Gantry 1, high-energy transmission pencil beams can be delivered to biological samples and detectors up to a maximum local dose rate of ∼9000 Gy/s. In the presented setup, a Faraday cup is used to measure the delivered number of protons up to ultra-high dose rates. The response of transmission ion-chambers, as well as of different field detectors, was characterized over a wide range of dose rates using the Faraday cup as reference. RESULTS The reproducibility of the delivered proton charge was better than 1 % in the proposed experimental setup. EBT3 films, Al2O3:C optically stimulated luminescence detectors and a PTW microDiamond were used to validate the predicted dose. Transmission ionization chambers showed significant volume ion-recombination (>30 % in the tested conditions) which can be parametrized as a function of the maximum proton current density. Over the considered range, EBT3 films, inorganic scintillator-based screens and the PTW microDiamond were demonstrated to be dose rate independent within ±3 %, ±1.8 % and ±1 %, respectively. CONCLUSIONS Faraday cups are versatile dosimetry instruments that can be used for dose estimation, field detector characterization and on-line dose verification for pre-clinical experiments in UHDR proton pencil beams. Among the tested detectors, the commercial PTW microDiamond was found to be a suitable option to measure real time the dosimetric properties of narrow pencil proton beams for dose rates up to 2.2 kGy/s

The Hubble Space Telescope Advanced Camera for Surveys Emission Line Survey of Andromeda. I: Classical Be Stars

We present results from a 2-epoch HST H$\alpha$ emission line survey of the Andromeda Galaxy that overlaps the footprint of the Panchromatic Hubble Andromeda Treasury (PHAT) survey. We find 552 (542) classical Be stars and 8429 (8556) normal B-type stars in epoch # 1 (epoch # 2), yielding an overall fractional Be content of 6.15% $\pm$0.26% (5.96% $\pm$0.25%). The fractional Be content decreased with spectral sub-type from $\sim$23.6% $\pm$2.0% ($\sim$23.9% $\pm$2.0%) for B0-type stars to $\sim$3.1% $\pm$0.34% ($\sim$3.4% $\pm$0.35%) for B8-type stars in epoch # 1 (epoch # 2). We observe a clear population of cluster Be stars at early fractional main sequence lifetimes, indicating that a subset of Be stars emerge onto the ZAMS as rapid rotators. Be stars are 2.8x rarer in M31 for the earliest sub-types compared to the SMC, confirming that the fractional Be content decreases in significantly more metal rich environments (like the Milky Way and M31). However, M31 does not follow a clear trend of Be fraction decreasing with metallicity compared to the Milky Way, which may reflect that the Be phenomenon is enhanced with evolutionary age. The rate of disk-loss or disk-regeneration episodes we observe, 22% $\pm$ 2% yr$^{-1}$, is similar to that observed for seven other Galactic clusters reported in the literature, assuming these latter transient fractions scale by a linear rate. The similar number of disk-loss events (57) as disk-renewal events (43) was unexpected since disk dissipation time-scales can be $\sim$2x the typical time-scales for disk build-up phases.Comment: Accepted to A

The modern pollen-vegetation relationship of a tropical forest-savannah mosaic landscape, Ghana, West Africa

Transitions between forest and savannah vegetation types in fossil pollen records are often poorly understood due to over-production by taxa such as Poaceae and a lack of modern pollen-vegetation studies. Here, modern pollen assemblages from within a forest-savannah transition in West Africa are presented and compared, their characteristic taxa discussed, and implications for the fossil record considered. Fifteen artificial pollen traps were deployed for 1 year, to collect pollen rain from three vegetation plots within the forest-savannah transition in Ghana. High percentages of Poaceae and Melastomataceae/Combretaceae were recorded in all three plots. Erythrophleum suaveolens characterised the forest plot, Manilkara obovata the transition plot and Terminalia the savannah plot. The results indicate that Poaceae pollen influx rates provide the best representation of the forest-savannah gradient, and that a Poaceae abundance of >40% should be considered as indicative of savannah-type vegetation in the fossil record