So YHWH established a sign for Cain\u27: Rethinking Genesis 4,15

The so-called mark of Cain has long been thought to be something God puts upon Cain\u27s body or a trait Cain would possess to deter would-be avengers. Often overlooked, however, are details immediately following the story Gen 4,17 – dealing with the building of a city – which may well indicate the sign. In this short note I argue that the sign might best be understood not as a mark upon the body, but as something God established for Cain\u27s protection – perhaps a city of refuge

Parasite-driven replacement of a sexual by a closely related asexual taxon in nature

Asexual species are thought to suffer more from coevolving parasites than related sexuals. Yet a variety of studies do not find the patterns predicted by theory. Here, to shine light on this conundrum, we investigate one such case of an asexual advantage in the presence of parasites. We follow the frequency dynamics of sexual and asexualDaphnia pulexin a natural pond that was initially dominated by sexuals. Coinciding with an epidemic of a microsporidian parasite infecting both sexuals and asexuals, the pond was rapidly taken over by the initially rare asexuals. With experiments comparing multiple sexual and asexual clones from across the local metapopulation, we confirm that asexuals are less susceptible and also suffer less from the parasite once infected. These results are consistent with the parasite-driven, ecological replacement of dominant sexuals by closely related, but more resistant asexuals, ultimately leading to the extinction of the formerly superior sexual competitor. Our study is one of the clearest examples from nature, backed up by experimental verification, showing a parasite-mediated reversal of competition dynamics. The experiments show that, across the metapopulation, asexuals have an advantage in the presence of parasites. In this metapopulation, asexuals are relatively rare, likely due to their recent invasion. While we cannot rule out other reasons for the observed patterns, the results are consistent with a temporary parasite-mediated advantage of asexuals due to the fact that they are rare, which is an underappreciated aspect of the Red Queen Hypothesis.Peer reviewe

Reduced lifespan and increased ageing driven by genetic drift in small populations

Explaining the strong variation in lifespan among organisms remains a major challenge in evolutionary biology. Whereas previous work has concentrated mainly on differences in selection regimes and selection pressures, we hypothesize that differences in genetic drift may explain some of this variation. We develop a model to formalize this idea and show that the strong positive relationship between lifespan and genetic diversity predicted by this model indeed exists among populations of Daphnia magna, and that ageing is accelerated in small populations. Additional results suggest that this is due to increased drift in small populations rather than adaptation to environments favoring faster life histories. First, the correlation between genetic diversity and lifespan remains significant after statistical correction for potential environmental covariates. Second, no trade-offs are observed; rather, all investigated traits show clear signs of increased genetic load in the small populations. Third, hybrid vigor with respect to lifespan is observed in crosses between small but not between large populations. Together, these results suggest that the evolution of lifespan and ageing can be strongly affected by genetic drift, especially in small populations, and that variation in lifespan and ageing may often be nonadaptive, due to a strong contribution from mutation accumulation

Found in Translation: Essays on Biblical Jewish Translation in Honor of Leonard J. Greenspoon

Found in Translation is at once a themed volume on the translation of ancient Jewish texts and a Festschrift for Leonard J. Greenspoon, the Philip M. and Ethel Klutznick Professor in Jewish Civilization and professor of classical and near Eastern studies and of theology at Creighton University in Omaha, Nebraska. Greenspoon has made significant contributions to the study of Jewish biblical translations, particularly the ancient translation of the Hebrew Bible into Greek, known as the Septuagint. This volume comprises an internationally renowned group of scholars presenting a wide range of original essays on Bible translation, the influence of culture on biblical translation, Bible translations’ reciprocal influence on culture, and the translation of various Jewish texts and collections, especially the Septuagint. Volume editors have painstakingly planned Found in Translation to have the broadest scope of any current work on Jewish biblical translation to reflect Greenspoon’s broad impact on the field throughout an august career.https://docs.lib.purdue.edu/purduepress_previews/1009/thumbnail.jp

OWL-based acquisition and editing of computer-interpretable guidelines with the CompGuide editor

Computer-Interpretable Guidelines (CIGs) are the dominant medium for the delivery of clinical decision support, given the evidence-based nature of their source material. Therefore, these machine-readable versions have the ability to improve practitioner performance and conformance to standards, with availability at the point and time of care. The formalisation of Clinical Practice Guideline knowledge in a machine-readable format is a crucial task to make it suitable for the integration in Clinical Decision Support Systems. However, the current tools for this purpose reveal shortcomings with respect to their ease of use and the support offered during CIG acquisition and editing. In this work, we characterise the current landscape of CIG acquisition tools based on the properties of guideline visualisation, organisation, simplicity, automation, manipulation of knowledge elements, and guideline storage and dissemination. Additionally, we describe the CompGuide Editor, a tool for the acquisition of CIGs in the CompGuide model for Clinical Practice Guidelines that also allows the editing of previously encoded guidelines. The Editor guides the users throughout the process of guideline encoding and does not require proficiency in any programming language. The features of the CIG encoding process are revealed through a comparison with already established tools for CIG acquisition.COMPETE, Grant/Award Number: POCI-01-0145-FEDER-007043; FCT - Fundacao para a Ciencia e Tecnologia, Grant/Award Number: UID/CEC/00319/201

Tobacco Use: Prevention, Cessation, and Control

Practice Center (RTI-UNC EPC) systematically reviewed the evidence on (a) the effectiveness of community- and population-based interventions to prevent tobacco use and to increase consumer demand for and implementation of effective cessation interventions; (b) the impacts of smokeless tobacco marketing on smoking, use of those products, and population harm; and (c) the directions for future research. Data Sources: We searched MEDLINE®, Cumulative Index to Nursing and Applied Health (CINAHL), Cochrane libraries, Cochrane Clinical Trials Register, Psychological Abstracts, and Sociological Abstracts from January 1980 through June 10, 2005. We included English-language randomized controlled trials, other trials, and observational studies, with sample size and followup restrictions. We used 15 Cochrane Collaboration systematic reviews, 5 prior systematic reviews, and 2 meta-analyses as the foundation for this report. Review Methods: Trained reviewers abstracted detailed data from included articles into evidence tables and completed quality assessments; other senior reviewers confirmed accuracy and resolved disagreements. Results: We identified 1,288 unique abstracts; 642 did not meet inclusion criteria, 156 overlapped with prior reviews, and 2 were not published articles. Of 488 full-text articles retrieved and reviewed, we excluded 298 for several reasons, marked 88 as background, and retained 102. Evidence (consistent with previous reviews) showed that (a) school-based prevention interventions have short-term (but not long-term) effects on adolescents; (b) multicomponent approaches, including telephone counseling, increase the number of users who attempt to quit; (c) self-help strategies alone are ineffective, but counseling and pharmacotherapy used either alone or in combination can improve success rates of quit attempts; and (d) provide training and academic detailing improve provider delivery of cessation treatments, but evidence is insufficient to show that these approaches yield higher quit rates. Recent evidence on the following topics was insufficient to change prior review findings: (a) effectiveness of population-based prevention interventions; (b) effectiveness of providerbased interventions to reduce tobacco initiation; (c) effectiveness of community- and providerbased interventions to increase use of proven cessation strategies; (d) effectiveness of marketing campaigns to switch tobacco users from smoking to smokeless tobacco products; and (e) effectiveness of interventions in populations with comorbidities and risk behaviors (e.g., depression, substance and alcohol abuse). No evidence was available on the way in which smokeless tobacco product marketing affects population harm. Conclusions: The evidence base has notable gaps and numerous study deficiencies. We found little information to address some of the issues that previous authoritative reviews had not covered, some information to substantiate earlier conclusions and recommendations from those reviews, and no evidence that would overturn any previous recommendations

VAPORES Y CORREOS INTERINSULARES [Material gráfico]

ADQUIRIDA POR EL COLECCIONISTA EN LAS PALMAS DE GRAN CANARIAFOTO SOBRE CARTON DE RETRATO DE GRUPO DE CINCO SEÑORES UNIFORMADOS BRINDANDOCopia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 201