Polymorphism of genes associated with infectious lung diseases in Northern Asian populations and in patients with community-acquired pneumonia

The innate Iнн\mmune system is the first to respond to invading pathogens. It is responsible for invader recognition, immune-cell recruitment, adaptive-immunity activation, and regulation of inflammation intensity. Previously, two single-nucleotide polymorphisms of innate-immunity genes – rs5743708 (Arg753Gln) of the TLR2 gene and rs8177374 (Ser180Leu) of the TIRAP gene – have been shown to be associated with both pneumonia and tuberculosis in humans, but the data are contradictory among different ethnic groups. It has also been reported that rs10902158 at the PKP3-SIGGIR-TMEM16J genetic locus belongs to a haplotype race-specifically associated with tuberculosis. Meanwhile, a gradient of its frequency is observed in Asia. The aim of this work was to assess the effect of selection for the genotypes of the above-mentioned SNPs on the gene pools of populations living in harsh climatic conditions that contribute to the development of infectious lung diseases. We estimated the prevalence of these variants in white and Asian (Chukchis and Yakuts) population samples from Northern Asia and among patients with community-acquired pneumonia (CAP). Carriage of the rs5743708 A allele was found to predispose to severe CAP (odds ratio 2.77, p = 0.021), whereas the GG/CT genotype of rs5743708/rs8177374 proved to be protective against it (odds ratio 0.478, p = 0.022) in white patients. No association of rs10902158 with CAP (total or severe) was found among whites. Stratification of CAP by causative pathogen may help eliminate the current discrepancies between different studies. No significant difference in rs5743708 or rs8177374 was found between adolescent and long-lived white samples. Carriage of the alleles studied is probably not associated with predisposition to longevity among whites in Siberia. Both white and Asian populations studied were different from Western European and East Asian populations in the variants’ prevalence. The frequency of the rs8177374 T (Ser180Leu) variant was significantly higher in the Chukchi sample (p = 0, χ2 = 63.22) relative to the East Asian populations. This result may confirm the hypothesis about the selection of this allele in the course of human migration into areas with unfavorable climatic conditions

Хронические неспецифические заболевания легких — биологический индикатор экологического благополучия крайнего Севера

Results of studying the complex influence of climatic factors on the North habitants are given. The data on the population morbidity and the comparative analysis of the morbidity level dependence on various social groups are presented. It was determined that the respiratory morbidity level is strongly effected by a complex of climatic and occupational factors.Приведены результаты изучения комплексного влияния климатических факторов на жителей Крайнего Севера. Приводятся данные по заболеваемости населения и сравнительный анализ в зависимости от группы обследуемого контингента. Установлено, что на уровень заболеваемости болезнями органов дыхания большое влияние оказывает комплекс климатических и профессиональных факторов

Meteoprotective properties of melaxen in old and middle aged patients with ischemic heart disease in combination with arterial hypertension

We studied 102 patients (mean age 60.1±3.3 years) with arterial hypertension (AH) II-III stage, grade 2-3 and ischemic heart disease (exertional angina functional class (FC) I-II, postinfarction cardiosclerosis). The control group of patients received traditional therapy (TT): beta -blockers, calcium channel blockers, ACE inhibitors, antiplatelet agents, diuretics and nitrate

Individual athletes’ biomechanical features of interaction with objects in art gymnastics

Purpose: To design a biomechanical model of interaction of athlete with the subject, as well as the development of areas of its use in practice. Material: The study involved 10 students - athletes. Results: The presented computational schemes create direction of flight of different items (rope, hoop, ball, ribbon, clubs). The characteristics of the time of flight trajectories and with regard for the resistance force of the air environment. Shows the influence of initial parameters on departure flight time items. Graphic characteristics are presented trajectories of objects depending on the parameters of their departure. Conclusions: It is recommended to improve the judicial assessment and effective implementation gymnast exercises during the flight characteristics of the various items to consider trajectories of objects. Note that age, height and distance from the athletes at the end of the flight object defined biomechanical characteristics that can realize an athlete: absolute initial velocity of departure, departure angle, height of the center of mass manufacture items

Luminescent coordination polymers based on Ca²⁺ and octahedral cluster anions [{M₆Clⁱ₈}Clᵃ₆}²⁻ (M = Mo, W) : synthesis and thermal stability studies

Luminescent coordination polymers (CPs) based of inexpensive stable precursors are attractive materials for applications. Here we report the synthesis and evaluation of the stability and photophysical characteristics of the first examples of phosphorescent CPs based on octahedral molybdenum and tungsten cluster anions. Specifically 1D CP trans-[{Ca(OPPh₃)₄}{{M₆Clⁱ₈}Clᵃ₆}]∞ (M = Mo, W) can be obtained either directly at increased temperature or via intermediate phases [cis-Ca(OPPh₃)₄(H₂O)₂][{M₆Clⁱ₈}Clᵃ₆]∙2CH₃CN that are stable at room-temperature, but convert to the titled CP at temperatures above 100 °C

Knot homology via derived categories of coherent sheaves II, sl(m) case

Using derived categories of equivariant coherent sheaves we construct a knot homology theory which categorifies the quantum sl(m) knot polynomial. Our knot homology naturally satisfies the categorified MOY relations and is conjecturally isomorphic to Khovanov-Rozansky homology. Our construction is motivated by the geometric Satake correspondence and is related to Manolescu's by homological mirror symmetry.Comment: 51 pages, 9 figure

GEMINGA: NEW OBSERVATIONS AT LOW RADIO FREQUENCIES

ABSTRACT. After nearly 10 years, we have succeeded to detect radio emission from Geminga more again. In this report we present new evidence for presence of radio emission from Geminga in the range 42-112 MHz. The observations were carried out on two sensitive transit radio telescopes We used three new digital receivers to detect the pulses and to obtain dynamic spectra.The examples of mean pulse profiles are presented. Exact value of the dispersion measure have been calculated using the simultaneous observations at three frequencies

The Role of Bilingual Language Experience in Executive Functioning

В работе описывается проект исследования по изучению феномена билингвального преимущества. Планируется изучение компонентов исполнительных функций (рабочей памяти, ингибиторного контроля, когнитивной гибкости) у выборки молодых взрослых, владеющих двумя языковыми парами (адыгейский-русский или татарский-русский). Согласно гипотезе исследования, билингвы, погруженные в разные культурно-языковые контексты, будут различаться по уровню билингвального языкового опыта и, следовательно, по показателям исполнительных функций.This is the research design of the project that aims at examining the bilingual advantage. The study will assess the following components of executive functions (working memory, inhibitory control, cognitive flexibility) in the sample of young adults native to two language pairs (Adyghe-Russian or Tatar-Russian). According to the research hypothesis, bilinguals immersed into different linguistic and cultural contexts will have various levels of bilingual language experience and, consequently, will differ in their executive functions

Associations of changes in lipid metabolism parameters and the severity of COVID-19 infection in Novosibirsk residents

Aim. To study the associations of changes in lipid metabolism parameters and the severity of a coronavirus disease 2019 (COVID-19).Material and methods. This cross-sectional study included 270 patients aged 26-84 years (mean age, 53,09±13,22 years) who had COVID-19 within prior two months, which were divided into 3 groups: mild (1, n=128), moderate (2, n=128) and severe (3, n=14) COVID-19. Patients were assessed for body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), total cholesterol, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C). In addition, atherogenic index of plasma (AIP) was calculated. Statistical processing was performed using the SPSS software package (version 13.0).Results. Patients with severe COVID-19 had significantly higher levels of TG and AIP compared with patients with moderate and mild course. BMI and WC were significantly higher in patients in groups 2 and 3 compared with patients in group 1. In women, BMI and AIP levels were significantly higher in the severe COVID-19 group compared to groups 1 and 2. HDL-C levels were lower in patients with severe COVID-19 compared to those with moderate disease. WHR was higher among men in group 3 compared with group 1.Conclusion. Patients with severe COVID-19 have higher BMI, WC, AIP, TG levels, and lower HD-C levels. The relative odds for severe COVID-19 are associated with increased WC, AIP, TG, and lower HDL-C

Detection of Five New RRATs at 111 MHz

Results of 111-MHz monitoring observations carried out on the Big Scanning Antenna of the Pushchino Radio Astronomy Observatory during September 1-28, 2015 are presented. Fifty-four pulsating sources were detected at declinations $-9^o < \delta < +42^o$. Forty-seven of these are known pulsars, five are new sources, and two are previously discovered transients. Estimates of the peak flux densities and dispersion measures are presented or all these sources.Comment: published in Astronomy Report, translated by Yandex translator with correction of scientific lexis, 8 pages, 2 figures, 3 table