The Muon (g-2) Theory Value: Present and Future

Whitepaper prepared for the US Particle Physics "Snowmass" Self StudyThis White Paper briefly reviews the present status of the muon (g-2) Standard-Model prediction. This value results in a 3 - 4 standard-deviation difference with the experimental result from Brookhaven E821. The present experimental uncertainty is ±63×10−11 (0.54~ppm), and the Standard-Model uncertainty is ≃±49×10−11. Fermilab experiment E989 has the goal to reduce the experimental error to ±16×10−11. Improvements in the Standard-Model value, which should be achieved between now and when the first results from Fermilab E989 could be available, should lead to a Standard-Model uncertainty of ~±35×10−11. These improvements would halve the uncertainty on the difference between experiment and theory, and should clarify whether the current difference points toward New Physics, or to a statistical fluctuation. At present, the (g-2) result is arguably the most compelling indicator of physics beyond the Standard Model and, at the very least, it represents a major constraint for speculative new theories such as supersymmetry, dark gauge bosons or extra dimensions

siRNA-Mediated <i>Timp1</i> Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury

Acute lung injury is a complex cascade process that develops in response to various damaging factors, which can lead to acute respiratory distress syndrome. Within this study, based on bioinformatics reanalysis of available full-transcriptome data of acute lung injury induced in mice and humans by various factors, we selected a set of genes that could serve as good targets for suppressing inflammation in the lung tissue, evaluated their expression in the cells of different origins during LPS-induced inflammation, and chose the tissue inhibitor of metalloproteinase Timp1 as a promising target for suppressing inflammation. We designed an effective chemically modified anti-TIMP1 siRNA and showed that Timp1 silencing correlates with a decrease in the pro-inflammatory cytokine IL6 secretion in cultured macrophage cells and reduces the severity of LPS-induced acute lung injury in a mouse model

CMD-3 Overview

The CMD-3 detector is installed at the VEPP-2000 e+e− collider at BINP (Novosibirsk, Russia). It is a general-purpose detector, equipped with a tracking system, two crystal (CSI and BGO) calorimeters, liquid Xe calorimeter, TOF and muon systems. The main goal of experiments at CMD-3 is a study of exclusive modes of e+e−→ hadrons at energies s≤2$\sqrt s \le$ GeV. In particular, these results provide an important input for calculation of the hadronic contribution to the muon anomalous magnetic moment. The first round of data taking was performed in 2011–2013, when about 60 1/pb were taken in the center-of-mass (c.m.) energy range from 0.32 to 2.0 GeV. Here we present a survey of results of data analysis. Between 2013 and 2016 the collider and the detector were upgraded. The data taking resumed by the end of 2016. In the first run after the upgrade about 50 1/pb were collected at the energy range between 1.28 and 2.007 GeV. We discuss the upgrade and the first preliminary results from the new data

CMD-3 Overview

The CMD-3 detector is installed at the VEPP-2000 e+e− collider at BINP (Novosibirsk, Russia). It is a general-purpose detector, equipped with a tracking system, two crystal (CSI and BGO) calorimeters, liquid Xe calorimeter, TOF and muon systems. The main goal of experiments at CMD-3 is a study of exclusive modes of e+e−→ hadrons at energies $\sqrt s \le$ GeV. In particular, these results provide an important input for calculation of the hadronic contribution to the muon anomalous magnetic moment. The first round of data taking was performed in 2011–2013, when about 60 1/pb were taken in the center-of-mass (c.m.) energy range from 0.32 to 2.0 GeV. Here we present a survey of results of data analysis. Between 2013 and 2016 the collider and the detector were upgraded. The data taking resumed by the end of 2016. In the first run after the upgrade about 50 1/pb were collected at the energy range between 1.28 and 2.007 GeV. We discuss the upgrade and the first preliminary results from the new data

CEPC Conceptual Design Report: Volume 2 - Physics & Detector

The Circular Electron Positron Collider (CEPC) is a large international scientific facility proposed by the Chinese particle physics community to explore the Higgs boson and provide critical tests of the underlying fundamental physics principles of the Standard Model that might reveal new physics. The CEPC, to be hosted in China in a circular underground tunnel of approximately 100 km in circumference, is designed to operate as a Higgs factory producing electron-positron collisions with a center-of-mass energy of 240 GeV. The collider will also operate at around 91.2 GeV, as a Z factory, and at the WW production threshold (around 160 GeV). The CEPC will produce close to one trillion Z bosons, 100 million W bosons and over one million Higgs bosons. The vast amount of bottom quarks, charm quarks and tau-leptons produced in the decays of the Z bosons also makes the CEPC an effective B-factory and tau-charm factory. The CEPC will have two interaction points where two large detectors will be located. This document is the second volume of the CEPC Conceptual Design Report (CDR). It presents the physics case for the CEPC, describes conceptual designs of possible detectors and their technological options, highlights the expected detector and physics performance, and discusses future plans for detector R&D and physics investigations. The final CEPC detectors will be proposed and built by international collaborations but they are likely to be composed of the detector technologies included in the conceptual designs described in this document. A separate volume, Volume I, recently released, describes the design of the CEPC accelerator complex, its associated civil engineering, and strategic alternative scenarios

CEPC Conceptual Design Report: Volume 2 - Physics & Detector

The Circular Electron Positron Collider (CEPC) is a large international scientific facility proposed by the Chinese particle physics community to explore the Higgs boson and provide critical tests of the underlying fundamental physics principles of the Standard Model that might reveal new physics. The CEPC, to be hosted in China in a circular underground tunnel of approximately 100 km in circumference, is designed to operate as a Higgs factory producing electron-positron collisions with a center-of-mass energy of 240 GeV. The collider will also operate at around 91.2 GeV, as a Z factory, and at the WW production threshold (around 160 GeV). The CEPC will produce close to one trillion Z bosons, 100 million W bosons and over one million Higgs bosons. The vast amount of bottom quarks, charm quarks and tau-leptons produced in the decays of the Z bosons also makes the CEPC an effective B-factory and tau-charm factory. The CEPC will have two interaction points where two large detectors will be located. This document is the second volume of the CEPC Conceptual Design Report (CDR). It presents the physics case for the CEPC, describes conceptual designs of possible detectors and their technological options, highlights the expected detector and physics performance, and discusses future plans for detector R&D and physics investigations. The final CEPC detectors will be proposed and built by international collaborations but they are likely to be composed of the detector technologies included in the conceptual designs described in this document. A separate volume, Volume I, recently released, describes the design of the CEPC accelerator complex, its associated civil engineering, and strategic alternative scenarios

CEPC Conceptual Design Report: Volume 2 - Physics & Detector

The Circular Electron Positron Collider (CEPC) is a large international scientific facility proposed by the Chinese particle physics community to explore the Higgs boson and provide critical tests of the underlying fundamental physics principles of the Standard Model that might reveal new physics. The CEPC, to be hosted in China in a circular underground tunnel of approximately 100 km in circumference, is designed to operate as a Higgs factory producing electron-positron collisions with a center-of-mass energy of 240 GeV. The collider will also operate at around 91.2 GeV, as a Z factory, and at the WW production threshold (around 160 GeV). The CEPC will produce close to one trillion Z bosons, 100 million W bosons and over one million Higgs bosons. The vast amount of bottom quarks, charm quarks and tau-leptons produced in the decays of the Z bosons also makes the CEPC an effective B-factory and tau-charm factory. The CEPC will have two interaction points where two large detectors will be located. This document is the second volume of the CEPC Conceptual Design Report (CDR). It presents the physics case for the CEPC, describes conceptual designs of possible detectors and their technological options, highlights the expected detector and physics performance, and discusses future plans for detector R&D and physics investigations. The final CEPC detectors will be proposed and built by international collaborations but they are likely to be composed of the detector technologies included in the conceptual designs described in this document. A separate volume, Volume I, recently released, describes the design of the CEPC accelerator complex, its associated civil engineering, and strategic alternative scenarios