Lessons from Argentina : the Buenos Aires Water Concession

As part of its research mandate the Municipal Services Project has been conducting comparative studies on the privatization of municipal services in other parts of Africa and Latin America. This report presents the findings of a study of the private water and sanitation concession in Buenos Aires, Argentina. This is the first major English-language study of the concession conducted outside of the World Bank Group since the concession began in 1993. The decision to conduct research on the Buenos Aires water system was taken for several reasons. First, it is one of the largest water concessions in the world – servicing a population of 10 million people – and has been hailed as a success story internationally. It is important, therefore, that South African policy makers review this model in their own deliberations over private sector involvement in water and sanitation delivery. Second, the major shareholder in the consortium that operates the water concession in Buenos Aires is Suez Lyonnaise des Eaux, a large French multinational that is also active in South Africa. Lyonnaise des Eaux is involved in the Johannesburg water management contract and has been actively pursuing contracts in other South African cities, as the opening quote to this executive summary attests to. Third, there have been at least two trips to Buenos Aires by South African policy makers and bureaucrats to review the water concession as a possible model for South African municipalities. The first trip, taken in 1997 by a councilor and a senior engineer from Cape Town (paid for by the French government), was extremely positive in its evaluation of the concession, arguing that it has been “remarkably successful” in turning around an otherwise “potentially disastrous situation” (Bekker and Marsden 1997, 10). A second trip taken in May of 2000, involving 12 senior local government officials from various parts of South Africa, was similarly positive in its review (PADCO 2000). Our own research findings are much more critical of the concession. Although there have been some positive developments in terms of investments in infrastructure and the extension of services since 1993 there have been some major failures as well. While some of these failures are unique to Buenos Aires and the politics of Argentina, they do raise some more general questions around the role of the private sector in the delivery of municipal services, and challenge some of the widely held arguments in favour of privatization. The following paragraphs provide a brief overview of the main findings of our research, with a specific focus on the themes of accountability and efficiency. Our intention here is to flag what we consider to be the most serious problems with the Buenos Aires water concession in hopes of contributing to the ongoing debate over private sector involvement in the water and sanitation sectors in South Africa..

Approaching stimuli bias attention in numerical space

Increasing evidence suggests that common mechanisms underlie the direction of attention in physical space and numerical space, along the mental number line. The small leftward bias (pseudoneglect) found on paper-and-pencil line bisection is also observed when participants ‘bisect’ number pairs, estimating (without calculating) the number midway between two others. Here we investigated the effect of stimulus motion on attention in numerical space. A two-frame apparent motion paradigm manipulating stimulus size was used to produce the impression that pairs of numbers were approaching (size increase from first to second frame), receding (size decrease), or not moving (no size change). The magnitude of pseudoneglect increased for approaching numbers, even when the final stimulus size was held constant. This result is consistent with previous findings that pseudoneglect in numerical space (as in physical space) increases as stimuli are brought closer to the participant. It also suggests that the perception of stimulus motion modulates attention over the mental number line and provides further support for a connection between the neural representations of physical space and number

New ages from Boomplaas Cave, South Africa, provide increased resolution on late/terminal Pleistocene human behavioural variability

Abstract: Boomplaas Cave, South Africa, contains a rich archaeological record, with evidence of human occupation from approximately 66,000 years ago until the protohistoric period. Notwithstanding a long history of research at the site, its existing chronology can benefit from revision. Many of the site’s members are currently delimited by only a single conventional radiocarbon date and some of the existing dates were measured on materials now known to be unsuitable for radiocarbon dating. Here we present the results of an ongoing effort to redate key late/terminal Pleistocene sequences in southern Africa. This paper presents a Bayesian-modelled radiocarbon chronology for the late/terminal Pleistocene horizons at Boomplaas. Our model incorporates previously published radiocarbon dates as well as new accelerator mass spectrometry ages. We also present archaeological evidence to examine in greater detail than was previously possible the nature of occupation patterning across the late/terminal Pleistocene and to assess technological change across two of the site’s Last Glacial Maximum (LGM) members. The new dates and archaeological data confirm that the site was occupied in a series of low intensity events in the early LGM and immediately thereafter. The site was occupied intensively in the terminal Pleistocene in line with major changes in palaeoenvironments and sea-level fluctuations. The lithic data show the use of variable technological strategies in contexts of shifting mobility and site occupation patterns. Our discussion informs upon huntergatherer behavioural variability that did not, and should not be expected to, reflect the strategies adopted and adapted by a handful of well-known arid-zone hunter-gatherers in the twentieth-century Kalahari

Ethnographies of Power

What does it mean to work with radical concepts in our time of rampant inequality, imperial-capitalist plunder, racial/sexual/class violence and ecocide? When concepts from the past seem inadequate, how do scholars and activists concerned with social change decide what concepts to work with or renew? The contributors to Ethnographies of Power address these questions head on. Gillian Hart is a key thinker in radical political economy, geography, development studies, agrarian studies and Gramscian critique of postcolonial capitalism. In Ethnographies of Power each contributor engages her work and applies it to their own field of study. These applied concepts include: ‘gendered labour’ practices among South African workers, reading ‘racial capitalism’ through agrarian debates, using ‘relational comparison’ in an ethnography of schooling across Durban, reworking ‘multiple socio-spatial trajectories’ in Guatemala’s Maya Biosphere Reserve, critiquing the notion of South Africa’s ‘second economy’, revisiting ‘development’ processes and ‘Development’ discourses in US military contracting, reconsidering Gramsci’s ‘conjunctures’ geographically, finding divergent ‘articulations’ in Cape Town land occupations, and exploring ‘nationalism’ as central to revaluing recyclables at a Soweto landfill. Ethnographies of Power offers an invaluable toolkit for activists and scholars engaged in sharpening their critical concepts for the social and environmental change necessary for our collective future

Sequencing and analysis of an Irish human genome

BACKGROUND: Recent studies generating complete human sequences from Asian, African and European subgroups have revealed population-specific variation and disease susceptibility loci. Here, choosing a DNA sample from a population of interest due to its relative geographical isolation and genetic impact on further populations, we extend the above studies through the generation of 11-fold coverage of the first Irish human genome sequence. RESULTS: Using sequence data from a branch of the European ancestral tree as yet unsequenced, we identify variants that may be specific to this population. Through comparisons with HapMap and previous genetic association studies, we identified novel disease-associated variants, including a novel nonsense variant putatively associated with inflammatory bowel disease. We describe a novel method for improving SNP calling accuracy at low genome coverage using haplotype information. This analysis has implications for future re-sequencing studies and validates the imputation of Irish haplotypes using data from the current Human Genome Diversity Cell Line Panel (HGDP-CEPH). Finally, we identify gene duplication events as constituting significant targets of recent positive selection in the human lineage. CONCLUSIONS: Our findings show that there remains utility in generating whole genome sequences to illustrate both general principles and reveal specific instances of human biology. With increasing access to low cost sequencing we would predict that even armed with the resources of a small research group a number of similar initiatives geared towards answering specific biological questions will emerge

Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors

SRC is a nonreceptor tyrosine kinase with key roles in breast cancer development and progression. Despite this, SRC tyrosine kinase inhibitors have so far failed to live up to their promise in clinical trials, with poor overall response rates. We aimed to identify possible synergistic gene–drug interactions to discover new rational combination therapies for SRC inhibitors. An unbiased genome-wide CRISPR-Cas9 knockout screen in a model of triple-negative breast cancer revealed that loss of integrin-linked kinase (ILK) and its binding partners α-Parvin and PINCH-1 sensitizes cells to bosutinib, a clinically approved SRC/ABL kinase inhibitor. Sensitivity to bosutinib did not correlate with ABL dependency; instead, bosutinib likely induces these effects by acting as a SRC tyrosine kinase inhibitor. Furthermore, in vitro and in vivo models showed that loss of ILK enhanced sensitivity to eCF506, a novel and highly selective inhibitor of SRC with a unique mode of action. Whole-genome RNA sequencing following bosutinib treatment in ILK knockout cells identified broad changes in the expression of genes regulating cell adhesion and cell–extracellular matrix. Increased sensitivity to SRC inhibition in ILK knockout cells was associated with defective adhesion, resulting in reduced cell number as well as increased G(1) arrest and apoptosis. These findings support the potential of ILK loss as an exploitable therapeutic vulnerability in breast cancer, enhancing the effectiveness of clinical SRC inhibitors. SIGNIFICANCE: A CRISPR-Cas9 screen reveals that loss of integrin-linked kinase synergizes with SRC inhibition, providing a new opportunity for enhancing the clinical effectiveness of SRC inhibitors in breast cancer

Interdisciplinary Design Studio: Programming Document Visioning for a Robotic Demonstration, Research, and Engagement Dairy

The 2022 COLLABORATE Design Studio brought together students from various disciplines to address a complex, real-world project which required collaborative input from different perspectives. The studio worked to advance the co-creation of knowledge between external stakeholders, students, and instructors. The course was co-taught by faculty from different disciplines, and areas of expertise. During the semester, Nate Bicak and Steven Hardy worked with students from Architecture and Interior Design in collaboration with students in Dr. Tami Brown-Brandl’s students in Biological Systems Engineering and Animal Science to explore the values, spatial qualities, and area requirements of a Robotic Demonstration, Research, and Engagement Dairy. Students organized a series of meetings and participatory activities to gather information from a range of project stakeholders including: Heather Akin (Agricultural Leadership, Education & Communication), Kris Bousquet (NE Dairy Association), Paul Kononoff (Animal Science), Eric Markvicka (Mechanical and Material Engineering), Julia McQuillan (Sociology), Santosh Pitla (BioSystems and Agricultural Engineering), Ling Ling Sun (NE Public Media), and Rosanna Villa Rojas (Food Science & Technology). The information gathered helped to frame the overall problem - both quantitative and qualitative - to be addressed during the design visioning stage (not included in this document). Student contributors included: Sarah Alduaylij, Noor Al-Maamari, Devyn Beekman, Kelsey Belgum, Lauren Chubb, Nicholas Forte, Mitchell Hill, Joshua Holstein, Dylan Lambe, Phuong Le, Mia LeRiger, Elizabeth Loftus, Josh Lorenzen , Megan Lovci, Alex Martino, Zade Miller, Hannah Morgan , Annabelle Nichols , Collin Shearman, Rebecca Sowl, Nalin Theplikhith, Angela Vu, Shaylee Wagner, Ethan Watermeier, Trever Zelenk