Vedolizumab for Inflammatory Bowel Disease:Two-Year Results of the Initiative on Crohn and Colitis (ICC) Registry, A Nationwide Prospective Observational Cohort Study: ICC Registry - Vedolizumab

Contains fulltext : 220028.pdf (Publisher’s version ) (Open Access)Prospective data of vedolizumab treatment for patients with inflammatory bowel disease (IBD) beyond 1 year of treatment is scarce but needed for clinical decision making. We prospectively enrolled 310 patients with IBD (191 with Crohn's disease (CD) and 119 patients with ulcerative colitis (UC)) with a follow-up period of 104 weeks (interquartile range: 103-104) in a nationwide registry. The corticosteroid-free clinical remission rate (Harvey Bradshaw Index ≤ 4, Short Clinical Colitis Activity index ≤ 2) at weeks 52 and 104 were 28% and 19% for CD and 27% and 28% for UC, respectively. Fifty-nine percent maintained corticosteroid-free clinical remission between weeks 52 and 104. Vedolizumab with concomitant immunosuppression showed comparable effectiveness outcomes compared with vedolizumab monotherapy (week 104: 21% vs. 23%; P = 0.77), whereas 8 of 13 severe infections occurred in patients treated with concomitant immunosuppression. To conclude, the clinical effect was 19% for CD and 28% for UC after 2 years of follow-up regardless of concomitant immunosuppression

Concordance in measurable residual disease result after first and second induction cycle in acute myeloid leukemia : An outcome- and cost-analysis

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Разработка способа получения оксида магния из доломитовой породы

Активный MgO широко используется в разных отраслях промышленности в том числе в качестве противослеживающего материала в технологии минеральных удобрений. Работа посвящена исследованию способа получения активного оксида магния из доломитовой породы бикарбонатным методом, осаждать гидрокарбонаты магния, из полученного раствора бикарбоната магния термическими и химическими методами. Цель работы–исследование бикарбонатным методом получения активного оксида магния из доломитовой породы.Active MgO is widely used in various industries, including as an anti-tracking material in mineral fertilizer technology. The work is devoted to the study of a method for obtaining active magnesium oxide from dolomite rock by the bicarbonate method, to precipitate magnesium bicarbonates, from the resulting solution of magnesium bicarbonate by thermal and chemical methods. The aim of the work is to study the bicarbonate method of obtaining active magnesium oxide from dolomite rock

Collective dynamics of confined rigid spheres and deformable drops

The evolution of linear arrays of rigid spheres and deformable drops in a Poiseuille flow between parallel walls is investigated to determine the effect of particle deformation on the collective dynamics in confined particulate flows. We find that linear arrays of rigid spheres aligned in the flow direction exhibit a particle-pairing instability and are unstable to lateral perturbations. Linear arrays of deformable drops also undergo the pairing instability but also exhibit additional dynamical features, including formation of transient triplets, cascades of pair-switching events, and the eventual formation of pairs with equal interparticle spacing. Moreover, particle deformation stabilizes drop arrays to lateral perturbations. These pairing and alignment phenomena are qualitatively explained in terms of hydrodynamic far-field dipole interactions that are insensitive to particle deformation and quadrupole interactions that are deformation induced. We suggest that quadrupole interactions may underlie the spontaneous formation of droplet strings in confined emulsions under shear [Phys. Rev. Lett., 2001, 86, 1023.