EDGeS: a bridge between desktop grids and service grids

Desktop grids and service grids widely used by their different users communities as efficient solutions for making full use of computing power and achieving loads balances across Intranet or Internet. Nevertheless,little work has been done to combine these two grids technologies together to establish a seamless and vast grid resources pool. In this paper we will present a new European FP7 infrastructure project:EDGeS (enabling desktop grids for e-science), which aim to build technological bridges to facilitate interoperability between desktop grid and service grid. We give also a taxonomy of existing grid systems: desktop grids such as BONIC and XtremWeb, service grids such as EGEE. Then we describe furtherly our solution for identifying translation technologies for porting applications between desktop grids and service grids, and vice versa. There are three themes in our solution, which discuss actual popular bridging technologies, user access issues, and distributed data issues about deployment and application development

Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny

Antenatal inflammation as seen with chorioamnionitis is harmful to foetal/neonatal organ development including to eyes. Although the major pro-inflammatory cytokine IL-1β participates in retinopathy induced by hyperoxia (a predisposing factor to retinopathy of prematurity), the specific role of antenatal IL-1β associated with preterm birth (PTB) in retinal vasculopathy (independent of hyperoxia) is unknown. Using a murine model of PTB induced with IL-1β injection in utero, we studied consequent retinal and choroidal vascular development; in this process we evaluated the efficacy of IL-1R antagonists. Eyes of foetuses exposed only to IL-1β displayed high levels of pro-inflammatory genes, and a persistent postnatal infiltration of inflammatory cells. This prolonged inflammatory response was associated with: (1) a marked delay in retinal vessel growth; (2) long-lasting thinning of the choroid; and (3) long-term morphological and functional alterations of the retina. Antenatal administration of IL-1R antagonists - 101.10 (a modulator of IL-1R) more so than Kineret (competitive IL-1R antagonist) - prevented all deleterious effects of inflammation. This study unveils a key role for IL-1β, a major mediator of chorioamnionitis, in causing sustained ocular inflammation and perinatal vascular eye injury, and highlights the efficacy of antenatal 101.10 to suppress deleterious inflammation.Alexandra Beaudry-Richard, Mathieu Nadeau-Vallée, Élizabeth Prairie, Noémie Maurice ... Sarah A. Robertson ... David M. Olson ... et al

The gravitational wave detector VIRGO

International audienc

Sandboxing for desktop grids using virtualization

Desktop Grids harvest the computing power of idle desktop computers whether these are volunteer or deployed at an institution. Allowing foreign applications to run on these resources requires the sender of the application to be trusted, but trust in goodwill is never enough. An efficient solution is to provide a secure isolated execution environment ("sandbox"), which does not constrain any additional burden neither on administrators nor on users. Currently Desktop Grids do not provide such facility. In this paper we investigate methods and mechanisms that enable the use of virtual machines as part of a security infrastructure for Desktop Grid clients to provide a sandbox for running (untrusted) applications. We define and analyze the requirements for any platform independent and transparent sandbox for Desktop Grids. We detail a prototype, which we built based on our findings and we give a performance evaluation

XtremWeb and Condor: Sharing Resources Between Internet Connected Condor Pool

Grid computing presents two major challenges for deploying large scale applications across wide area networks gathering volunteers PC and clusters/parallel computers as computational resources: security and fault tolerance. This paper presents a lightweight Grid solution for the deployment of multi-parameters applications on a set of clusters protected by firewalls. The system uses a hierarchical design based on Condor for managing each cluster locally and XtremWeb for enabling resource sharing among the clusters. We discuss the security and fault tolerance mechanisms used for this design and demonstrate the usefulness of the approach measuring the performances of a multi-parameters bio-chemistry application deployed on two sites: University of Wisconsin/Madison and Paris South University. This experiment shows that we can efficiently and safely harness the computational power of about 200 PC distributed on two geographic sites.