The synthesis and properties of some pyrido [1, 2-a] Pyrazinum Salts

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Anticancer Drug Development

British Journal of Cancer (2002) 86, 1665–1666. DOI: 10.1038/sj/bjc/6600309 www.bjcancer.co

Saskatchewan health stakeholders and the 1991-96 wellnesss program

Powerful, entrenched health care stakeholders played a major role in limiting the health reform initiative of the Government of Saskatchewan in the 1990s. The politics of the decade was dominated by the fiscal crisis which prompted the government to embark on health care reform at the same times as it limited the scope of the reform. The narrative of Saskatchewan’s health reform efforts showed that the government focused on the politics of health care, specifically the need to manage the diverse and often competing interests of health care stakeholders. It also reveals the dynamic between the stakeholders, the press and public opinion. As health stakeholders expressed their concerns about health care reform, the press and the public became more critical and the government backed away from its commitment to health reform

The Structural Validity of the Ohio Ninth Grade Proficiency Test

The structural validity of the Ohio Ninth Grade Proficiency Test was investigated with the test scores of 713 eighth graders who had their first opportunity to take the test in March 1999 in a large urban school district in Ohio. The study examined a hypothetical structure of the test to determine its fit to the data. Confirmatory factor analysis was performed, and several fit indices including χ2 statistics and the root- mean-square error of approximation were examined. The theoretical structure of the test was first found to be valid, and then the invariance of the structure was examined across males and females. Both the tests of structural fidelity and invariance were cross-validated using a sample of 735 eighth graders who took the parallel test in March 2002. The results provided evidence of the invariance of factor loadings and factor variances in both years. Factor covariances were found to be invariant in 1999, but this was not confirmed by 2002. Results consistently showed the lack of invariance of error variances

Membrane-type matrix metalloproteinases: expression, roles in metastatic prostate cancer progression and opportunities for drug targeting

YesThe membrane-type matrix metalloproteinases (MT-MMPs), an important subgroup of the wider MMP family, demonstrate widespread expression in multiple tumor types, and play key roles in cancer growth, migration, invasion and metastasis. Despite a large body of published research, relatively little information exists regarding evidence for MT-MMP expression and function in metastatic prostate cancer. This review provides an appraisal of the literature describing gene and protein expression in prostate cancer cells and clinical tissue, summarises the evidence for roles in prostate cancer progression, and examines the data relating to MT-MMP function in the development of bone metastases. Finally, the therapeutic potential of targeting MT-MMPs is considered. While MT-MMP inhibition presents a significant challenge, utilisation of MT-MMP expression and proteolytic capacity in prostate tumors is an attractive drug development opportunity

Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(eta(6)-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF(6), is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible toxicity. Its activity appears to involve redox mechanisms and its potency towards A2780 ovarian and A549 lung cancer cells is increased significantly in combination with L-buthionine-sulfoximine