Augustanism in Henry James: his reception of Horace, Virgil, Livy & Tacitus

This thesis examines the influence of Latin literature and values on the fiction of Henry James, with particular reference to the authors who wrote under Augustus, the first emperor of Rome. The similarities between their works and his are analysed in terms of structure, style, setting, plot, theme, imagery, characterisation and didacticism by close readings and comparisons of the texts. The writings to be compared are Horace’s Odes with James’s “Daisy Miller,” Virgil’s Aeneid with The Ambassadors, and the histories of Livy and Tacitus with The Golden Bowl. In the end, this dissertation attempts to demonstrate how the morals that James sought to commend to his young and burgeoning America were based on those of the ancient Augustan age, a period that he may have believed bore a strong resemblance to his own times, while he may also have felt that emulation and appropriation of these canonical classical writers could help him to become a classic himself. The results of this enquiry are offered as a contribution to both classical reception studies and Jamesian studies

The distinction between conscious and unconscious cognition in David R. Shanks’s work: A critical assessment

Abstract The notion of unconscious finds support in many experimental studies that use the dissociation method. This method allows us to distinguish between conscious and unconscious mental states when participants cannot explain why they performed as they did in an experiment. The paper will discuss the notion of unconscious by considering David R. Shanks’ criticisms of the application of the dissociation method: it will assess three studies Shanks proposes as reexaminations of three other relevant studies in the literature and show how Shanks’ work provides an examination of the methodological pitfalls of such studies. The paper will argue that, although Shanks’s results are relevant regarding theories about the structure of cognition, his theoretical positions are at best confused and at worst diminish the importance of his research outcomes. It will conclude by showing why Shanks’s results that legitimize the role of consciousness in cognition can be problematic for the physicalistic or materialistic framework endorsed by cognitive psychologists.Keywords: Dissociation Method; Dual-process Theories; Cognitive Psychology; Consciousness; UnconsciousLa distinzione tra cognizione conscia e inconscia nell’opera di D.R. Schanks: una valutazione criticaRiassunto: La nozione di inconscio trova supporto in vari studi sperimentali che utilizzano il metodo della dissociazione. Secondo la letteratura cognitivista questo metodo permette di distinguere tra stati mentali consci e inconsci quando i partecipanti non sono in grado di riportare verbalmente il perché si sono comportati in un certo modo durante l’esecuzione di un compito sperimentale. Il presente articolo discute la nozione di inconscio in relazione alle critiche di David R. Shanks all’applicazione del metodo della dissociazione. Più precisamente, esso valuta tre studi che Shanks propone come repliche e rivalutazioni di altrettante ricerche a favore della cognizione inconscia e mostra l’autore riesca con successo a metterne in luce le carenze metodologiche. Inoltre, sostiene anche che, sebbene i risultati sperimentali di Shanks siano importanti per le teorie sulla struttura della cognizione, le sue posizioni teoriche sono quantomeno confuse e rischiano di ridimensionare la portata delle sue conclusioni empiriche e metodologiche. L’articolo conclude mostrando le ragioni per cui i risultati di Shanks, che legittimano il ruolo della coscienza nella cognizione, siano controversi in quanto adottano una posizione filosofica fisicalistica o materialistica comune alla maggioranza degli psicologi cognitivi.Parole chiave: Metodo della dissociazione; Teorie del doppio processo; Psicologia cognitiva; Coscienza; InconscioAbstract The notion of unconscious finds support in many experimental studies that use the dissociation method. This method allows us to distinguish between conscious and unconscious mental states when participants cannot explain why they performed as they did in an experiment. The paper will discuss the notion of unconscious by considering David R. Shanks’ criticisms of the application of the dissociation method: it will assess three studies Shanks proposes as reexaminations of three other relevant studies in the literature and show how Shanks’ work provides an examination of the methodological pitfalls of such studies. The paper will argue that, although Shanks’s results are relevant regarding theories about the structure of cognition, his theoretical positions are at best confused and at worst diminish the importance of his research outcomes. It will conclude by showing why Shanks’s results that legitimize the role of consciousness in cognition can be problematic for the physicalistic or materialistic framework endorsed by cognitive psychologists.Keywords: Dissociation Method; Dual-process Theories; Cognitive Psychology; Consciousness; Unconscious La distinzione tra cognizione conscia e inconscia nell’opera di D.R. Schanks: una valutazione criticaRiassunto: La nozione di inconscio trova supporto in vari studi sperimentali che utilizzano il metodo della dissociazione. Secondo la letteratura cognitivista questo metodo permette di distinguere tra stati mentali consci e inconsci quando i partecipanti non sono in grado di riportare verbalmente il perché si sono comportati in un certo modo durante l’esecuzione di un compito sperimentale. Il presente articolo discute la nozione di inconscio in relazione alle critiche di David R. Shanks all’applicazione del metodo della dissociazione. Più precisamente, esso valuta tre studi che Shanks propone come repliche e rivalutazioni di altrettante ricerche a favore della cognizione inconscia e mostra l’autore riesca con successo a metterne in luce le carenze metodologiche. Inoltre, sostiene anche che, sebbene i risultati sperimentali di Shanks siano importanti per le teorie sulla struttura della cognizione, le sue posizioni teoriche sono quantomeno confuse e rischiano di ridimensionare la portata delle sue conclusioni empiriche e metodologiche. L’articolo conclude mostrando le ragioni per cui i risultati di Shanks, che legittimano il ruolo della coscienza nella cognizione, siano controversi in quanto adottano una posizione filosofica fisicalistica o materialistica comune alla maggioranza degli psicologi cognitivi.Parole chiave: Metodo della dissociazione; Teorie del doppio processo; Psicologia cognitiva; Coscienza; Inconsci

Reasons versus Causes in Arocha’s Scientific Realism

Arocha’s scientific realism (2021) puts at the center of psychology the individual and their variability in behavior: the individual appears to be irreducible to what emerges from the analysis of aggregate data. According to this position, psychology’s aim is to uncover the mechanisms underlying the observable world. This entails adopting the cause-based approach of the natural sciences. Arocha’s article also refers to final causes and intentions and thus to the reason-based approach of the human sciences in contrast to that of the natural sciences. Thus, it is not clear whether the article aims to reduce the final causes to mechanical causes or supports the irreducibility of the former. Starting from these remarks, this comment will argue that the reason-based approach is preferable to the cause-based approach in order to have a scientific psychology. Adopting the reason-based approach also avoids the appeal to aggregate data by focusing upon the single case

The Relationship between Introspection and Folk Psychology: An Overview

The epistemic status of introspection remains a controversial topic. due to its subjective char- acter, introspection is not an easy fit with natural sciences or a physicalistic picture of the mind. In literature, introspection is conceived as dealing only with macro-cognition and not with micro-cognition, the supposed object of study of scientific psychology. This essay dis- cusses the epistemic status of introspection in light of its relationship with folk psychology and spells it out through an analysis of the positions of Wilkes, Alston, Schwitzgebel, and Churchland. Specifically, the essay makes a distinction between folk and scientific psychol- ogy and addresses the issue of the incorrigibility/infallibility of introspective judgments. The essay endorses a view according to which introspection should be conceived as a cognitive process the contents of which are provided by folk knowledge. It shows how this view can be appreciated as scientific, provided that a physicalistic image of the mind is rejected

Role of metformin and AKT axis modulation in the reversion of hypoxia induced TMZ-resistance in glioma cells

Hypoxia is a key driver of tumor adaptation promoting tumor progression and resistance to therapy. Hypoxia related pathways might represent attractive targets for the treatment of Glioblastoma Multiforme (GBM), that up to date is characterized by a poor prognosis. Primary aim of this study was to investigate the role of hypoxia and hypoxia-related modifications in the effect of temozolomide (TMZ) given alone or in association with the antidiabetic agent Metformin (MET) or the PI3K/mTOR blocker, BEZ235. The study was conducted in the TMZ responsive U251 and resistant T98 GBM cells. Our results showed that during hypoxia, TMZ plus MET reduced viability of U251 cells affecting also CD133 and CD90 expressing cells. This effect was associated with a reduction of HIF-1\u3b1 activity, VEGF release and AKT activation. In T98 TMZ-resistant cells, TMZ plus MET exerted similar effects on HIF-1\u3b1. However, in this cell line, TMZ plus MET failed to reduce CD133 positive cells and AKT phosphorylation. Nevertheless, the administration of the dual PI3K/mTOR inhibitor BEZ235 potentiated the effect of TMZ plus MET on cell viability, inducing a pro-apoptotic phenotype during hypoxic condition also in T98 cells, suggesting the block of the PI3K/AKT/mTOR pathway as a complementary target to further overcome GBM resistance during hypoxia. In conclusion, we proposed TMZ plus MET as suitable treatment to revert TMZ-resistance also during hypoxia, an effect potentiated by the inhibition of PI3K/mTOR axis

Hypoxia-Inducible Factor-1α Activity as a Switch for Glioblastoma Responsiveness to Temozolomide

RationaleThe activity of the transcription factor, hypoxia-inducible factor (HIF)-1α, is a common driver of a number of the pathways involved in the aggressiveness of glioblastomas (GBMs), and it has been suggested that the reduction in this activity observed, soon after the administration of temozolomide (TMZ), can be a biomarker of an early response in GBM models. As HIF-1α is a tightly regulated protein, studying the processes involved in its downregulation could shed new light on the mechanisms underlying GBM sensitivity or resistance to TMZ.MethodsThe effect of HIF-1α silencing on cell responsiveness to TMZ was assessed in four genetically different human GBM cell lines by evaluating cell viability and apoptosis-related gene balance. LAMP-2A silencing was used to evaluate the contribution of chaperone-mediated autophagy (CMA) to the modulation of HIF-1α activity in TMZ-sensitive and TMZ-resistant cells.ResultsThe results showed that HIF-1α but not HIF-2α activity is associated with GBM responsiveness to TMZ: its downregulation improves the response of TMZ-resistant cells, while blocking CMA-mediated HIF-1α degradation induces resistance to TMZ in TMZ-sensitive cells. These findings are in line with the modulation of crucial apoptosis-related genes.ConclusionOur results demonstrate the central role played by HIF-1α activity in determining the sensitivity or resistance of GBMs to TMZ, and we suggest that CMA is the cellular mechanism responsible for modulating this activity after TMZ treatment

Multivariate statistical analysis of the polyphenols content for the discrimination of honey produced in Sicily (Southern Italy)

The polyphenols content of 105 honey samples produced by black honeybees (Apis Mellifera ssp. Sicula) and common honeybees (Apis mellifera ssp. Ligustica) from Western Sicily (Southern Italy) was examined using TurboFlow™ liquid chromatography Orbitrap™ high-resolution mass spectrometry. The results showed very high kaempferol and quercetin contents, with average values higher than what was reported in literature (3967.9±2184.16 and 2206.1±1666.4μg kg⁠−1 for kaempferol and quercetin, respectively). The honey samples produced by Apis Mellifera ssp. Sicula subspecies showed polyphenols content up to two times higher than Apis mellifera ssp. Ligustica. The Principal Component Analysis (PCA) model calculated on the polyphenols content showed a satisfactory separation of the honey samples in terms of honeybee subspecies and production area. The model proposed in this work shows the possibility to safeguard the authenticity of the honey produced in the various geographic areas of Sicily