Low-frequency microwave radiometer for N-ROSS

The all weather, global determination of sea surface temperature (SST) has been identified as a requirement needed to support naval operations. The target SST accuracy is + or - 1.0 K with a surface resolution of 10 km. Investigations of the phenomenology and technology of remote passive microwave sensing of the ocean environment over the past decade have demonstrated that this objective is presently attainable. Preliminary specification and trade off studies were conducted to define the frequency, polarization, scan geometry, antenna size, and other esstential parameters of the low frequency microwave radiometer (LFMR). It will be a dual polarized, dual frequency system at 5.2 and 10.4 GHz using a 4.9 meter deployable mesh surface antenna. It is to be flown on the Navy-Remote Ocean Sensing System (N-ROSS) satellite scheduled to be launched in late 1988

Field-induced structure transformation in electrorheological solids

We have computed the local electric field in a body-centered tetragonal (BCT) lattice of point dipoles via the Ewald-Kornfeld formulation, in an attempt to examine the effects of a structure transformation on the local field strength. For the ground state of an electrorheological solid of hard spheres, we identified a novel structure transformation from the BCT to the face-centered cubic (FCC) lattices by changing the uniaxial lattice constant c under the hard sphere constraint. In contrast to the previous results, the local field exhibits a non-monotonic transition from BCT to FCC. As c increases from the BCT ground state, the local field initially decreases rapidly towards the isotropic value at the body-centered cubic lattice, decreases further, reaching a minimum value and increases, passing through the isotropic value again at an intermediate lattice, reaches a maximum value and finally decreases to the FCC value. An experimental realization of the structure transformation is suggested. Moreover, the change in the local field can lead to a generalized Clausius-Mossotti equation for the BCT lattices.Comment: Submitted to Phys. Rev.

Similarity transformations approach for a generalized Fokker-Planck equation

By using similarity transformations approach, the exact propagator for a generalized one-dimensional Fokker-Planck equation, with linear drift force and space-time dependent diffusion coefficient, is obtained. The method is simple and enables us to recover and generalize special cases studied through the Lie algebraic approach and the Green function technique.Comment: 8 pages, no figure

A phase III, multi-centre, double-masked randomised controlled trial of adjunctive intraocular and peri-ocular steroid (triamcinolone acetonide) versus standard treatment in eyes undergoing vitreoretinal surgery for open globe trauma (ASCOT): statistical analysis plan.

BACKGROUND: Open globe ocular trauma complicated by intraocular scarring (proliferative vitreoretinopathy) is a relatively rare, blinding, but potentially treatable condition for which, at present, surgery is often unsatisfactory and visual results frequently poor. To date, no pharmacological adjuncts to surgery have been proven to be effective. The aim of the Adjunctive Steroid Combination in Ocular Trauma (ASCOT) randomised controlled trial is to determine whether adjunctive steroid (triamcinolone acetonide), given at the time of surgery, can improve the outcome of vitreoretinal surgery in patients with open globe ocular trauma. This article presents the statistical analysis plan for the main publication as approved and signed off by the Trial Steering Committee prior to the first data extraction for the Data Monitoring Committee meeting report. METHODS/DESIGN: ASCOT is a pragmatic, multi-centre, parallel-group, double-masked randomised controlled trial. The aim of the study is to recruit from 20-25 centres in the United Kingdom and randomise 300 eyes (from 300 patients) into two treatment arms. Both groups will receive standard surgical treatment and care; the intervention arm will additionally receive a pre-operative steroid combination (triamcinolone acetonide) into the vitreous cavity consisting of 4 mg/0.1 ml and 40 mg/1 ml sub-Tenon's. Participants will be followed for 6 months post-surgery. The primary outcome is the proportion of patients achieving a clinically meaning improvement in visual acuity in the study eye at 6 months after initial surgery, defined as a 10 letter score improvement in the ETDRS (the standard scale to test visual acuity). TRIAL REGISTRATION: ISRCTN30012492 . Registered on 5 September 2014. EudraCT2014-002193-37 . Registered on 5 September 2014

Extraction of Airways with Probabilistic State-space Models and Bayesian Smoothing

Segmenting tree structures is common in several image processing applications. In medical image analysis, reliable segmentations of airways, vessels, neurons and other tree structures can enable important clinical applications. We present a framework for tracking tree structures comprising of elongated branches using probabilistic state-space models and Bayesian smoothing. Unlike most existing methods that proceed with sequential tracking of branches, we present an exploratory method, that is less sensitive to local anomalies in the data due to acquisition noise and/or interfering structures. The evolution of individual branches is modelled using a process model and the observed data is incorporated into the update step of the Bayesian smoother using a measurement model that is based on a multi-scale blob detector. Bayesian smoothing is performed using the RTS (Rauch-Tung-Striebel) smoother, which provides Gaussian density estimates of branch states at each tracking step. We select likely branch seed points automatically based on the response of the blob detection and track from all such seed points using the RTS smoother. We use covariance of the marginal posterior density estimated for each branch to discriminate false positive and true positive branches. The method is evaluated on 3D chest CT scans to track airways. We show that the presented method results in additional branches compared to a baseline method based on region growing on probability images.Comment: 10 pages. Pre-print of the paper accepted at Workshop on Graphs in Biomedical Image Analysis. MICCAI 2017. Quebec Cit

DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.

Deleted in liver cancer 1 (DLC1) is a RhoGTPase activation protein-containing tumor suppressor that associates with various types of cancer. Although DLC2 shares a similar domain structure with that of DLC1, the function of DLC2 is not well characterized. Here, we describe the expression and ablation of DLC2 in mice using a reporter-knockout approach. DLC2 is expressed in several tissues and in endothelial cells (ECs) of blood vessels. Although ECs and blood vessels show no histological abnormalities and mice appear overall healthy, DLC2-mutant mice display enhanced angiogenic responses induced by matrigel and by tumor cells. Silencing of DLC2 in human ECs has reduced cell attachment, increased migration, and tube formation. These changes are rescued by silencing of RhoA, suggesting that the process is RhoA pathway dependent. These results indicate that DLC2 is not required for mouse development and normal vessel formation, but may protect mouse from unwanted angiogenesis induced by, for example, tumor cells

A size of ~1 AU for the radio source Sgr A* at the centre of the Milky Way

Although it is widely accepted that most galaxies have supermassive black holes (SMBHs) at their centers^{1-3}, concrete proof has proved elusive. Sagittarius A* (Sgr A*)^4, an extremely compact radio source at the center of our Galaxy, is the best candidate for proof^{5-7}, because it is the closest. Previous Very Long Baseline Interferometry (VLBI) observations (at 7mm) have detected that Sgr A* is ~2 astronomical unit (AU) in size^8, but this is still larger than the "shadow" (a remarkably dim inner region encircled by a bright ring) arising from general relativistic effects near the event horizon^9. Moreover, the measured size is wavelength dependent^{10}. Here we report a radio image of Sgr A* at a wavelength of 3.5mm, demonstrating that its size is \~1 AU. When combined with the lower limit on its mass^{11}, the lower limit on the mass density is 6.5x10^{21} Msun pc^{-3}, which provides the most stringent evidence to date that Sgr A* is an SMBH. The power-law relationship between wavelength and intrinsic size (The size is proportional to wavelength^{1.09}), explicitly rules out explanations other than those emission models with stratified structure, which predict a smaller emitting region observed at a shorter radio wavelength.Comment: 18 pages, 4 figure