Microcanonical versus Canonical Analysis of Protein Folding

The microcanonical analysis is shown to be a powerful tool to characterize the protein folding transition and to neatly distinguish between good and bad folders. An off-lattice model with parameter chosen to represent polymers of these two types is used to illustrate this approach. Both canonical and microcanonical ensembles are employed. The required calculations were performed using parallel tempering Monte Carlo simulations. The most revealing features of the folding transition are related to its first-order-like character, namely, the S-bend pattern in the caloric curve, which gives rise to negative microcanonical specific heats, and the bimodality of the energy distribution function at the transition temperatures. Models for a good folder are shown to be quite robust against perturbations in the interaction potential parameters.Comment: 4 pages, 4 figure

Complex Tasks Force Hand Laterality and Technological Behaviour in Naturalistically Housed Chimpanzees: Inferences in Hominin Evolution

Clear hand laterality patterns in humans are widely accepted. However, humans only elicit a significant hand laterality pattern when performing complementary role differentiation (CRD) tasks. Meanwhile, hand laterality in chimpanzees is weaker and controversial. Here we have reevaluated our results on hand laterality in chimpanzees housed in naturalistic environments at Fundació Mona (Spain) and Chimfunshi Wild Orphanage (Zambia). Our results show that the difference between hand laterality in humans and chimpanzees is not as great as once thought. Furthermore, we found a link between hand laterality and task complexity and also an even more interesting connection: CRD tasks elicited not only the hand laterality but also the use of tools. This paper aims to turn attention to the importance of this threefold connection in human evolution: the link between CRD tasks, hand laterality, and tool use, which has important evolutionary implications that may explain the development of complex behaviour in early hominins

Experiments on a videotape atom chip: fragmentation and transport studies

This paper reports on experiments with ultra-cold rubidium atoms confined in microscopic magnetic traps created using a piece of periodically-magnetized videotape mounted on an atom chip. The roughness of the confining potential is studied with atomic clouds at temperatures of a few microKelvin and at distances between 30 and 80 microns from the videotape-chip surface. The inhomogeneities in the magnetic field created by the magnetized videotape close to the central region of the chip are characterized in this way. In addition, we demonstrate a novel transport mechanism whereby we convey cold atoms confined in arrays of videotape magnetic micro-traps over distances as large as ~ 1 cm parallel to the chip surface. This conveying mechanism enables us to survey the surface of the chip and observe potential-roughness effects across different regions.Comment: 29 pages, 22 figures

Artificial termite-fishing tasks as enrichment for sanctuary-housed chimpanzees: Behavioral effects and impact on welfare

The welfare of captive animals is nowadays a topic of major concern. In order to express their natural behavioral repertoires, however, animals require complex environments and stimuli which are difficult to reproduce in captivity. To overcome this, environmental enrichment is considered one of the most successful tools to increase behavioral opportunities and enhance animal welfare. In this study, we explored whether providing an artificial termite-fishing task, and whether participation in this task, predicted changes in the solitary and social behavior of sanctuary-housed chimpanzees (Pan troglodytes). We compared chimpanzee behavior when the enrichment was presented to different periods without enrichment. We found that the presence of the enrichment predicted an increase in tool use and feeding behavior and a decrease in inactivity, especially for those chimpanzees with higher participation. However, we did not detect significant changes in abnormal or self-directed behaviors. Furthermore, we found no variation in affiliation- or aggression-related behaviors, but social proximity increased in chimpanzees that participated more. Our results support previous studies demonstrating that artificial termite-fishing promotes species-typical behaviors in captive chimpanzees with no major effects on social activities

Evaluación del comportamiento de las fábricas de ladrillos de tejar y argamasa debido a la humedad que asciende por capilaridad

For a better understanding of the behaviour of old brick masonry in facing the rising damp problem, multiple tests were made in the laboratory: water absorption, moisture content, apparent porosity, temperature and thermal camera imaging on brick masonry and its components: brick and mortar. This has allowed us to determine which of the previous tests is the best in predicting the behaviour of a real wall. In addition, the tests have also helped in defining a process to evaluate the moisture content of walls in a buildings, which is important for heritage restoration projects.Para un mejor conocimiento del comportamiento de las fábricas antiguas de ladrillo frente a la ascensión capilar de agua, se han realizado en laboratorio ensayos de absorción de agua, de contenido de humedad, de porosidad aparente, de temperatura e imágenes con cámara termográfica sobre muros de fábrica y sus materiales componentes: ladrillo y argamasa. Ello ha permitido inferir cuál es el ensayo realizado a los ladrillos que mejor predice el comportamiento del muro real. También ha permitido definir un procedimiento para evaluar el contenido de humedad de fábricas existentes, importante para los proyectos de restauración del patrimonio construido

Size-Controlled Water-Soluble Ag Nanoparticles

Ag nanoparticles of two different sizes (1 and 4 nm) were prepared within an apoferritin cavity by using an Ag+-loaded apoferritin as a nanoconfined environment for their construction. The initial amount of Ag' ions injected in the apoferritin cavity dictates the size of the final Ag particles. The protein shell prevents bulk aggregation of the metal particles, which renders them water soluble and extremely stable

Comparison of the ENATE approach and discontinuous Galerkin spectral element method in 1D nonlinear transport equations

In this paper a comparison of the performance of two ways of discretizing the nonlinear convection-diffusion equation in a one-dimensional (1D) domain is performed. The two approaches can be considered within the class of high-order methods. The first one is the discontinuous Galerkin method, which has been profusely used to solve general transport equations, either coupled as the Navier-Stokes equations, or on their own. On the other hand, the ENATE procedure (Enhanced Numerical Approximation of a Transport Equation), uses the exact solution to obtain an exact algebraic equation with integral coefficients that link nodal values with a three-point stencil. This paper is the first of thorough assessments of ENATE by comparing it with well-established high-order methods. Several test cases of the steady Burgers' equation with and without source have been chosen for comparison