Novedades terapéuticas en el tratamiento del asma

International audienc

A tip-tilt hardware-in-the-loop air-bearing test bed with physical emulation of the relative orbital dynamics

29th AAS/AIAA Space Flight Mechanics Meeting: Ka’anapali, Maui, Hawaii, U.S.A. Volume: Advances in the Astronautical Sciences (Vol. 168, pp. 3781–3799). Univelt Inc.A new hardware-in-the-loop (HIL) air bearing testbed that is capable of physically emulating the relative orbital dynamics is presented. Typically, air bearing testbeds consist of test vehicles operating on top of a planar and horizontally-leveled sur face. These test vehicles use air bearings to reduce the friction with the operating surface to negligible levels. The low friction, combined with the horizontally leveled surface, creates a low residual acceleration environment. These dynamics are representative of the environment that spacecraft experience during close proximity maneuvers. To extend the applicability of planar air bearing test beds to longer maneuvers or separations relative orbital dynamics need to be emulated. In this paper, using Hill-Clohessy-Wilshire dynamics, we emulated the relative orbital dynamics of a real spacecraft using a scaled Floating Spacecraft Simulator (FSS) on a dynamically inclined operating surface. The mathematical constructs of the tilt angles, screw height displacements and scaling parameters are developed via Euler’s rotation theorem, Buckingham’s Pi theorem and the similarity principle. The applicability of the new idea is demonstrated via a circumnavigation maneuver scenario of a spacecraft in a Low Earth Orbit (LEO). The simulation results show the viability and suitability of the new approach

Commissioning and performance results of the WFIRST/PISCES integral field spectrograph

The Prototype Imaging Spectrograph for Coronagraphic Exoplanet Studies (PISCES) is a high contrast integral field spectrograph (IFS) whose design was driven by WFIRST coronagraph instrument requirements. We present commissioning and operational results using PISCES as a camera on the High Contrast Imaging Testbed at JPL. PISCES has demonstrated ability to achieve high contrast spectral retrieval with flight-like data reduction and analysis techniques.Comment: Author's copy - Proceedings of SPIE Volume 10400. Citation to SPIE proceedings volume will be added when availabl

Alternative academic approaches for testing homologous recombination deficiency in ovarian cancer in the MITO16A/MaNGO-OV2 trial

Molecular testing; Ovarian cancerProves moleculars; Càncer d'ovarisPruebas moleculares; Cáncer de ovariosBackground The detection of homologous recombination deficiency (HRD) can identify patients who are more responsive to platinum and poly ADP ribose polymerase inhibitors (PARPi). MyChoice CDx (Myriad) is the most used HRD test in ovarian cancer (OC). However, some limitations of commercial tests exist, because of the high rate of inconclusive results, costs, and the impossibility of evaluating functional resistance mechanisms. Patients and methods Two academic genomic tests and a functional assay, the RAD51 foci, were evaluated to detect HRD. One hundred patients with high-grade OC enrolled in the MITO16A/MaNGO-OV2 trial and treated with first-line therapy with carboplatin, paclitaxel, and bevacizumab were analyzed. Results The failure rate of the two genomic assays was 2%. The sensitivity in detecting HRD when compared with Myriad was 98.1% and 90.6%, respectively. The agreement rate with Myriad was 0.92 and 0.87, with a Cohen’s κ coefficient corresponding to 0.84 and 0.74, respectively. For the RAD51 foci assay, the failure rate was 30%. When the test was successful, discordant results for deficient and proficient tumors were observed, and additional HRD patients were identified compared to Myriad; sensitivity was 82.9%, agreement rate was 0.65, and Cohen’s κ coefficient was 0.18. The HRD detected by genomic assays and residual tumor at primary surgery and stage was correlated with progression-free survival at multivariate analysis. Conclusions Results suggest the feasibility of academic tests for assessing HRD status that show robust concordance with Myriad and correlation with clinical outcome. The contribution of the functional information related to the RAD51 foci test to the genomic data needs further investigation.This work was supported by funding from the AIRC [grant numbers IG 2016 – ID. 18921 and IG 2021 – ID. 25932 projects – P.I. SP and CO-2018-12367051 (Ministero della Salute) P.I SP]; Ricerca Corrente grant M2/7 from Ministero della Salute to DC, Ricerca Corrente from Ministero della Salute to SP. SM is supported by the Italian Association for Cancer Research [grant number IG-2017 n: IG19997]. MITO16A/MaNGO-OV2 trial was partially supported by Roche. AL is a recipient of a grant from the Asociación Española contra el Cáncer (AECC) [grant number INVES20095LLOP]. VS is a recipient of a grant from the Instituto de Salud Carlos III [grant number CPII19/00033] and a European grant for personalized medicine [grant number ERAPERMED 2019-215]. BP is a recipient of a grant from GOIRC. BP was supported by ESMO with a Clinical Translational Fellowship aid supported by Roche. Any views, opinions, findings, conclusions, or recommendations expressed in this material are those solely of the authors and do not necessarily reflect those of ESMO or Roche. NC has received funding from AstraZeneca (to the institution). FP has received funding from Roche, AstraZeneca, Pfizer, Merck Sharp & Dome, Bayer, Incyte, Taiho Oncology, Janssen Cilag, Exelixis, Aileron, and Daiichi Sankyo (grants to the institution for clinical trial activities)

Simultaneous Dual-tracer PET Imaging of the Rat Brain and its Application in the Study of Cerebral Ischemia

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Campeonato Mundial de Patinaje Artístico Reus 2014: opinión de los participantes y legado económico

The last days of September and beginning of October 2014 was held in the city of Reus Artistic Skating World Championships. This event welcomes the different types of skating and brought together about 1,200 athletes and 20 thousand spectators. The degree of satisfaction among athletes reached the score of 8.5 out of 10, while among the audience was 8.1 note. The loyalty expressed favorably since 95% of respondents would recommend attending a show of similar characteristics, while 90% of athletes are also evident in this sense. The estimated direct spending that has reversed in the territory is estimated at 2.1 million euros. The investment multiplier was 3.22, while the multiplier on the consumption reached the figure of 2.29 for the expenditure of the organization and spending 2.71 assistants. In overall, it is estimated for the whole economy of Catalonia a positive effect by 5.5 million euros. The most benefited sectors from these effects are tourism (22.8%), trade (14.8%), business services (14.2%) and transport and communications (10%).En 2014 se ha celebrado en Reus el Campeonato Mundial de Patinaje Artístico. Este evento acoge las distintas modalidades de patinaje. Participaron 1.200 deportistas y cerca de 20 mil espectadores. La satisfacción entre el público alcanzó la puntuación de 8,5, sobre 10, y 8,1 entre los deportistas. La fidelización se expresó favorablemente puesto que el 95% del público asistente y el 90% de los deportistas encuestados recomendarían a sus amigos y familiares la asistencia a un espectáculo parecido. El gasto directo estimado que ha revertido en el territorio es de 2,1 millones (euros). El multiplicador de la inversión es 3,22, mientras que el multiplicador relativo al consumo alcanza la cifra de 2,29 para el gasto de la organización y 2,71 para el gasto de asistentes. El efecto total se estima, para el conjunto de la economía de Cataluña, en 5,5 millones de euros. Los sectores más beneficiados son el turismo (22,8%), comercio (14,8%), servicios a empresas (14,2%) y transporte y comunicaciones (10%)

Improved respiratory parameters with skin-to-skin contact in premature infants with bronchopulmonary dysplasia on NIV-NAVA.

AIM: To determine if skin-to-skin contact (SSC) improved respiratory parameters in premature infants with evolving or established bronchopulmonary dysplasia (BPD) on non-invasive neutrally adjusted ventilator assist (NIV-NAVA). METHODS: Premature infants (<32 weeks gestational age) with BPD on NIV-NAVA were studied. Continuous readings from the Edi catheter (modified nasogastric feeding tube inserted for NAVA ventilation) were compared: pre-SSC (baby in incubator) and end-SSC (just before end of SSC). RESULTS: Sixty-five episodes of SSC were recorded in 12 premature infants with median gestational age at birth of 24.4 (23.1-27.0) weeks and birth weight of 642 (530-960) grams. Peak Edi (uV) in end-SSC 11.5 (2.7-38.7) was significantly lower compared to pre-SSC 15.8 (4.0-36.6), p < 0.001. P mean (cmH2 O) was significantly lower in end-SSC 9.7 (7.3-15.4) compared to pre-SSC 10.3 (7.5-15.5), p = 0.008. Respiratory rate (breaths/min) was significantly lower in end-SSC 52.9 (31.1-78.1) compared to pre-SSC 53.4 (35.1-74.1), p = 0.031. There was no significant difference in inspired oxygen requirement or time on back-up mode in end-SSC 40.0 (22.1-56.1) and 5.9 (0.0-56.0) compared to pre-SSC 39.0 (26.0-56.1) and 5.1 (0.0-29.3), p = 0.556 and p = 0.853 respectively. CONCLUSION: SSC improved respiratory parameters in premature infants with evolving or established BPD on NIV-NAVA

High-contrast spectroscopy testbed for Segmented Telescopes: instrument overview and development progress

The High Contrast spectroscopy testbed for Segmented Telescopes (HCST) is being developed at Caltech. It aims at addressing the technology gap for future exoplanet imagers and providing the U.S. community with an academic facility to test components and techniques for high contrast imaging, focusing on segmented apertures proposed for future ground-based (TMT, ELT) and space-based telescopes (HabEx, LUVOIR). We present an overview of the design of the instrument and a detailed look at the testbed build and initial alignment. We offer insights into stumbling blocks encountered along the path and show that the testbed is now operational and open for business. We aim to use the testbed in the future for testing of high contrast imaging techniques and technologies with amongst with thing, a TMT-like pupil

High-contrast spectroscopy testbed for segmented telescopes

The High Contrast Spectroscopy Testbed for Segmented Telescopes (HCST) at Caltech is aimed at filling gaps in technology for future exoplanet imagers and providing the U.S. community with an academic facility to test components and techniques for high contrast imaging with future segmented ground-based telescope (TMT, E-ELT) and space-based telescopes (HabEx, LUVOIR). The HCST will be able to simulate segmented telescope geometries up to 1021 hexagonal segments and time-varying external wavefront disturbances. It also contains a wavefront corrector module based on two deformable mirrors followed by a classical 3-plane single-stage corona- graph (entrance apodizer, focal-plane mask, Lyot stop) and a science instrument. The back-end instrument will consist of an imaging detector and a high-resolution spectrograph, which is a unique feature of the HCST. The spectrograph instrument will utilize spectral information to characterize simulated planets at the photon-noise limit, measure the chromaticity of new optimized coronagraph and wavefront control concepts, and test the overall scientific functions of high-resolution spectrographs on future segmented telescopes

Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study

AbstractBackgroundATP-binding cassette (ABC) transporters have been associated with methylmercury (MeHg) toxicity in experimental animal models.AimsTo evaluate the association of single nucleotide polymorphisms (SNPs) in maternal ABC transporter genes with 1) maternal hair MeHg concentrations during pregnancy and 2) child neurodevelopmental outcomes.Materials and methodsNutrition Cohort 2 (NC2) is an observational mother-child cohort recruited in the Republic of Seychelles from 2008–2011. Total mercury (Hg) was measured in maternal hair growing during pregnancy as a biomarker for prenatal MeHg exposure (N=1313) (mean 3.9ppm). Infants completed developmental assessments by Bayley Scales of Infant Development II (BSID-II) at 20months of age (N=1331). Genotyping for fifteen SNPs in ABCC1, ABCC2 and ABCB1 was performed for the mothers.ResultsSeven of fifteen ABC SNPs (ABCC1 rs11075290, rs212093, and rs215088; ABCC2 rs717620; ABCB1 rs10276499, rs1202169, and rs2032582) were associated with concentrations of maternal hair Hg (p<0.001 to 0.013). One SNP (ABCC1 rs11075290) was also significantly associated with neurodevelopment; children born to mothers with rs11075290 CC genotype (mean hair Hg 3.6ppm) scored on average 2 points lower on the Mental Development Index (MDI) and 3 points lower on the Psychomotor Development Index (PDI) than children born to mothers with TT genotype (mean hair Hg 4.7ppm) while children with the CT genotype (mean hair Hg 4.0ppm) had intermediate BSID scores.DiscussionGenetic variation in ABC transporter genes was associated with maternal hair Hg concentrations. The implications for MeHg dose in the developing child and neurodevelopmental outcomes need to be further investigated