504 research outputs found
Intrinsic Localized Modes Observed in the High Temperature Vibrational Spectrum of NaI
Inelastic neutron measurements of the high-temperature lattice excitations in
NaI show that in thermal equilibrium at 555 K an intrinsic mode, localized in
three dimensions, occurs at a single frequency near the center of the spectral
phonon gap, polarized along [111]. At higher temperatures the intrinsic
localized mode gains intensity. Higher energy inelastic neutron and x-ray
scattering measurements on a room-temperature NaI crystal indicate that the
creation energy of the ground state of the intrinsic localized mode is 299 meV.Comment: 17 pages, 5 figures Revised version; final versio
Magnetism and unconventional superconductivity in CeMIn heavy-fermion crystals
We review magnetic, superconducting and non-Fermi-liquid properties of the
structurally layered heavy-fermion compounds CeMIn (M=Co, Rh,
Ir). These properties suggest d-wave superconductivity and proximity to an
antiferromagetic quantum-critical point.Comment: submitted 23rd International Conference on Low Temperature Physics
(LT-23), Aug. 200
Influence of ABO locus on PFA-100 collagen-ADP closure time is not totally dependent on the von willebrand factor. Results of a GWAS on gait-2 project phenotypes
(1) Background: In a previous study, we found that two phenotypes related to platelet reactivity, measured with the PFA-100 system, were highly heritable. The aim of the present study was to identify genetic determinants that influence the variability of these phenotypes: Closure time of collagen-ADP (Col-ADP) and of collagen-epinephrine (Col-Epi). (2) Methods: As part of the GAIT-2 (Genetic Analysis of Idiopathic Thrombophilia (2) Project, 935 individuals from 35 large Spanish families were studied. A genome-wide association study (GWAS) with ≈ 10 M single nucleotide polymorphisms (SNPs) was carried out with Col-ADP and Col-Epi phenotypes. (3) Results: The study yielded significant genetic signals that mapped to the ABO locus. After adjusting both phenotypes for the ABO genotype, these signals disappeared. After adjusting for von Willebrand factor (VWF) or for coagulation factor VIII (FVIII), the significant signals disappeared totally for Col-Epi phenotype but only partially for Col-ADP phenotype. (4) Conclusion: Our results suggest that the ABO locus exerts the main genetic influence on PFA-100 phenotypes. However, while the effect of the ABO locus on Col-Epi phenotype is mediated through VWF and/or FVIII, the effect of the ABO locus on Col-ADP phenotype is partly produced through VWF and/or FVIII, and partly through other mechanisms
Crystal fields, disorder, and antiferromagnetic short-range order in Yb0.24Sn0.76Ru
We report extensive measurements on a new compound (Yb0.24Sn0.76)Ru that
crystallizes in the cubic CsCl structure. Valence band photoemission and L3
x-ray absorption show no divalent component in the 4f configuration of Yb.
Inelastic neutron scattering (INS) indicates that the eight-fold degenerate
J-multiplet of Yb3+ is split by the crystalline electric field (CEF) into a
{\Gamma}7 doublet ground state and a {\Gamma}8 quartet at an excitation energy
20 meV. The magnetic susceptibility can be fit very well by this CEF scheme
under the assumption that a {\Gamma}6 excited state resides at 32 meV; however,
the {\Gamma}8/{\Gamma}6 transition expected at 12 meV was not observed in the
INS. The resistivity follows a Bloch- Gr\"uneisen law shunted by a parallel
resistor, as is typical of systems subject to phonon scattering with no
apparent magnetic scattering. All of these properties can be understood as
representing simple local moment behavior of the trivalent Yb ion. At 1 K,
there is a peak in specific heat that is too broad to represent a magnetic
phase transition, consistent with absence of magnetic reflections in neutron
diffraction. On the other hand, this peak also is too narrow to represent the
Kondo effect in the {\Gamma}7 ground state doublet. On the basis of the
field-dependence of the specific heat, we argue that antiferromagnetic
shortrange order (possibly co-existing with Kondo physics) occurs at low
temperatures. The long-range magnetic order is suppressed because the Yb site
occupancy is below the percolation threshold for this disordered compound
Novel Coexistence of Superconductivity with Two Distinct Magnetic Orders
The heavy fermion Ce(Rh,Ir)In5 system exhibits properties that range from an
incommensurate antiferromagnet on the Rh-rich end to an exotic superconductor
on the Ir-rich end of the phase diagram. At intermediate composition where
antiferromagnetism coexists with superconductivity, two types of magnetic order
are observed: the incommensurate one of CeRhIn5 and a new, commensurate
antiferromagnetism that orders separately. The coexistence of f-electron
superconductivity with two distinct f-electron magnetic orders is unique among
unconventional superconductors, adding a new variety to the usual coexistence
found in magnetic superconductors.Comment: 3 figures, 4 page
The role of food addiction and lifetime substance use on eating disorder treatment outcomes
Food addiction (FA) and substance use (SU) in eating disorders (ED) have been associated with a more dysfunctional clinical and psychopathological profile. However, their impact on treatment outcomes has been poorly explored. Therefore, this transdiagnostic study is aimed at examining whether the presence of FA and/or SU is associated with treatment outcomes in patients with different ED types. The results were not able to reveal significant differences in treatment outcomes between patients with and without FA and/or SU; however, the effect sizes suggest higher dropout rates in the group with both FA and SU. The predictive models of treatment outcomes showed different features associated with each group. High persistence (i.e., tendency to perseverance and inflexibility) was the personality trait most associated with poor treatment outcomes in patients without addictions. High harm avoidance and younger age at ED onset were the variables most related to poor outcomes in patients with FA or SU. Finally, in the group with both addictive behaviors (FA and SU), the younger patients presented the poorest outcomes. In conclusion, our results suggest that, regardless of presenting addictive behaviors, patients with ED may similarly benefit from treatment. However, it may be important to consider the differential predictors of each group that might guide certain treatment targets
An mRNA expression-based signature for oncogene-induced replication-stress
Oncogene-induced replication stress characterizes many aggressive cancers. Several treatments are being developed that target replication stress, however, identification of tumors with high levels of replication stress remains challenging. We describe a gene expression signature of oncogene-induced replication stress. A panel of triple-negative breast cancer (TNBC) and non-transformed cell lines were engineered to overexpress CDC25A, CCNE1 or MYC, which resulted in slower replication kinetics. RNA sequencing analysis revealed a set of 52 commonly upregulated genes. In parallel, mRNA expression analysis of patient-derived tumor samples (TCGA, n=10,592) also revealed differential gene expression in tumors with amplification of oncogenes that trigger replication stress (CDC25A, CCNE1, MYC, CCND1, MYB, MOS, KRAS, ERBB2, and E2F1). Upon integration, we identified a six-gene signature of oncogene-induced replication stress (NAT10, DDX27, ZNF48, C8ORF33, MOCS3, and MPP6). Immunohistochemical analysis of NAT10 in breast cancer samples (n=330) showed strong correlation with expression of phospho-RPA (R=0.451, p=1.82x10(-20)) and γH2AX (R=0.304, p=2.95x10(-9)). Finally, we applied our oncogene-induced replication stress signature to patient samples from TCGA (n=8,862) and GEO (n=13,912) to define the levels of replication stress across 27 tumor subtypes, identifying diffuse large B cell lymphoma, ovarian cancer, TNBC and colorectal carcinoma as cancer subtypes with high levels of oncogene-induced replication stress
CALIDAD DE VIDA Y NECESIDADES DE FORMACIÓN DE LAS CUIDADORAS FORMALES DE PERSONAS MAYORES DEPENDIENTES INSTITUCIONALIZADAS
Objective: To identify the life quality and personal and job satisfaction of geriatrics assistants, caregivers of the institutionalized elderly. Methodology: Descriptive study made from quantitative and qualitative data. The sample size was 12 geriatrics assistants that work in the center Sociosanitario Ricardo Fortuny and in Sant Francesc de Vilafranca del Penedès Residence. Results: Most of them are satisfied with their personal life and have good life quality. They like their job and are motivated. However, they stated being little appreciated and badly paid. They think training is important to deliver quality care. Conclusion and discussion: Specialized training is needed to deliver quality care to the institutionalized elderly, as it does not only affect the job satisfaction of geriatrics assistants but also their personal satisfaction and quality of life.Objetivo: Identificar la calidad de vida, satisfacción personal y laboral de las Auxiliares de Geriatría cuidadoras de personas mayores institucionalizadas. Metodología: Estudio descriptivo realizado a partir de datos cuantitativos y datos cualitativos. El tamaño de la muestra fue de 12 Auxiliares de Geriatría que trabajan en el Centro Sociosanitario Ricard Fortuny y en la Residencia Sant Francesc de Vilafranca del Penedès. Resultados: La mayoría está satisfecha con su vida personal y tienen una buena calidad de vida. Les gusta su trabajo y están motivadas, sin embargo, manifiestan estar poco valoradas y remuneradas, piensan que la formación es importante para ofrecer unos cuidados de calidad. Conclusiones y discusión: Se necesita una formación especializada para ofrecer unos cuidados de calidad a los mayores institucionalizados, ello no sólo influye en la satisfacción laboral de las Auxiliares de Geriatría, sino también en su satisfacción personal y calidad de vida
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