Assessment of motor coordination in primary education of Barcelona and province

El presente estudio tiene por objetivo valorar la coordinación motora de estudiantes de primaria de Barcelona y provincia. Para la evaluación se ha utilizado el test KTK en el que participaron 1254 personas, 670 niños y 584 niñas, de edades entre 7 y 10 años. Se realizó el análisis descriptivo y la comparación entre género y edad. Los resultados indican que más del 40% de la población estudiada presenta una coordinación por debajo de la normalidad, cerca de un 57% de la muestra fue clasificado con coordinación normal y solamente el 4,6% lo ha sido por encima de esta clasificación. Los chicos han presentado resultados significativamente mejores que las chicas. Los datos del estudio no permiten generalizar los resultados, sin embargo como es una muestra representativa, nos lleva a creer que la población de alumnos en educación primaria de Barcelona y su provincia tiene un nivel coordinativo por debajo del esperado para su edadThe present study aims to assess motor coordination of primary-school students of Barcelona and its province. For evaluation we used the KTK test. 1254 people, 670 boys and 584 girls with ages between 7 and 10 years participated in the study. Descriptive analysis and the comparison between gender and age were performed. The results indicate that about 40% of the population studied presents results below normal, around 57% were classified with normal coordination and only 4.6% has been above this rating. The boys have presented significantly better results than girls. The study data do not permit to generalize the results, however as a representative sample, it leads us to believe that the student population in elementary education from Barcelona and its province has a coordinative level below expected for their ageAgrupació de Recerca en Ciències de l’Educació. U

Autoantibody screening in Guillain-Barré syndrome

Background: Guillain-Barré syndrome (GBS) is an acute inflammatory neuropathy with a heterogeneous presentation. Although some evidences support the role of autoantibodies in its pathogenesis, the target antigens remain unknown in a substantial proportion of GBS patients. The objective of this study is to screen for autoantibodies targeting peripheral nerve components in Guillain-Barré syndrome. Methods: Autoantibody screening was performed in serum samples from all GBS patients included in the International GBS Outcome study by 11 different Spanish centres. The screening included testing for anti-ganglioside antibodies, anti-nodo/paranodal antibodies, immunocytochemistry on neuroblastoma-derived human motor neurons and murine dorsal root ganglia (DRG) neurons, and immunohistochemistry on monkey peripheral nerve sections. We analysed the staining patterns of patients and controls. The prognostic value of anti-ganglioside antibodies was also analysed. Results: None of the GBS patients (n = 100) reacted against the nodo/paranodal proteins tested, and 61 (61%) were positive for, at least, one anti-ganglioside antibody. GBS sera reacted strongly against DRG neurons more frequently than controls both with IgG (6% vs 0%; p = 0.03) and IgM (11% vs 2.2%; p = 0.02) immunodetection. No differences were observed in the proportion of patients reacting against neuroblastoma-derived human motor neurons. Reactivity against monkey nerve tissue was frequently detected both in patients and controls, but specific patterns were only detected in GBS patients: IgG from 13 (13%) patients reacted strongly against Schwann cells. Finally, we confirmed that IgG anti-GM1 antibodies are associated with poorer outcomes independently of other known prognostic factors. Conclusion: Our study confirms that (1) GBS patients display a heterogeneous repertoire of autoantibodies targeting nerve cells and structures; (2) gangliosides are the most frequent antigens in GBS patients and have a prognostic value; (3) further antigen-discovery experiments may elucidate other potential antigens in GBS