The archaeological record from gruta El Manzano and their implicances for Nodpatagonia archaeology

En este trabajo se presentan los resultados de los análisis realizados sobre los materiales del sitio arqueológico Gruta de El Manzano, localizado sobre el río Grande, en el Departamento de Malargüe, al sur de la provincia de Mendoza. Utilizando la información generada, se discuten aspectos de la funcionalidad del sitio, los cambios a través del tiempo y se destaca su importancia para la discusión de los temas de la arqueología del norte de Patagonia. Los recientes fechados radiocarbónicos ubican al inicio de las ocupaciones en más de 8.000 años AP y confirman la existencia del hiatus regional para el Holoceno medio. Los materiales analizados muestran importantes cambios en las tendencias de los mismos, especialmente hacia la segunda mitad del Holoceno tardío, donde los diferentes indicadores sugieren diferencias en relación a la movilidad, el uso de la fauna, los recursos vegetales y la incorporación de tecnología cerámica.In this paper we present the results of the analysis carried out with the materials from Gruta de El Manzano archaeological site, located beside Grande River, in Malargüe, southern Mendoza province. Using the new information, we discuss the site function, changes trough time, and remark his importance for the northern Patagonia discussion. The last radiocarbon data place the beginning of the occupation in more than 8.000 years BP and confirm the existence of the mid Holocene regional hiatus. The analiced materials shows important changes in their tendencies, especially during the second half of the late Holocene, were different lines of evidencies suggest changes in relation to the mobility, the use of animal and plant resources and the incorporation of pottery technology.Facultad de Ciencias Naturales y Muse

The archaeological record from gruta El Manzano and their implicances for Nodpatagonia archaeology

En este trabajo se presentan los resultados de los análisis realizados sobre los materiales del sitio arqueológico Gruta de El Manzano, localizado sobre el río Grande, en el Departamento de Malargüe, al sur de la provincia de Mendoza. Utilizando la información generada, se discuten aspectos de la funcionalidad del sitio, los cambios a través del tiempo y se destaca su importancia para la discusión de los temas de la arqueología del norte de Patagonia. Los recientes fechados radiocarbónicos ubican al inicio de las ocupaciones en más de 8.000 años AP y confirman la existencia del hiatus regional para el Holoceno medio. Los materiales analizados muestran importantes cambios en las tendencias de los mismos, especialmente hacia la segunda mitad del Holoceno tardío, donde los diferentes indicadores sugieren diferencias en relación a la movilidad, el uso de la fauna, los recursos vegetales y la incorporación de tecnología cerámica.In this paper we present the results of the analysis carried out with the materials from Gruta de El Manzano archaeological site, located beside Grande River, in Malargüe, southern Mendoza province. Using the new information, we discuss the site function, changes trough time, and remark his importance for the northern Patagonia discussion. The last radiocarbon data place the beginning of the occupation in more than 8.000 years BP and confirm the existence of the mid Holocene regional hiatus. The analiced materials shows important changes in their tendencies, especially during the second half of the late Holocene, were different lines of evidencies suggest changes in relation to the mobility, the use of animal and plant resources and the incorporation of pottery technology.Facultad de Ciencias Naturales y Muse

Estudio aerobiológico de la diversidad polínica y su potencial alergénico en el oasis del sur de Mendoza, Argentina

Los conocimientos provenientes del campo de estudio de la Aerobiología favorecen el análisis inmunológico de los alérgenos atmosféricos procedentes de polen y esporas fúngicas. Esto posibilita conocer la carga alergénica del aire en el ambiente y de esta manera, valorar mejor la relación exposición / reacción / clínica en los pacientes en tratamiento por alergias. No existen estudios previos de este tema realizados a nivel regional ni provincial en Mendoza. Una base de datos de identificación de posibles alérgenos provenientes de la polinización de espacios verdes urbanos en la ciudad de San Rafael y General Alvear contribuye a la epidemiología ambiental sobre las afecciones alérgicas respiratorias inducidas por polen y esporas. En esta presentación damos a conocer un proyecto de investigación en Aerobiología, con el fin de generar conocimiento aerobiológico de la zona urbana del oasis del sur mendocino (San Rafael y General Alvear), que contribuye a conocer la carga alergénica proveniente de granos de polen y esporas presentes en el ambiente. Para ello, se están llevando a cabo tres líneas de trabajo que consisten en: (1) el relevamiento, localización y mapeo de la vegetación urbana en floración, (2) la elaboración de una colección de referencia palinológica, y (3) el muestreo diario de aeropartículas atmosféricas urbanas. Se presentan los resultados preliminares obtenidos desde el inicio del proyecto y se muestran las líneas de trabajo que seguirá el curso de esta investigación. A futuro, los estudios aerobiológicos permitirían el desarrollo de programas de seguimiento, prevención y control en los índices de la cantidad de polen y esporas presentes en la atmósfera. Esta herramienta puede describir el potencial alergénico en espacios urbanos sus perjuicios ambientales. De esta manera, una investigación con estas características puede ser un aporte directo a la formulación de políticas de salud pública y planificación urbana de la ciudad.Fil: Guerci, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Museo Municipal de Historia Natural San Rafael - Unidad Asociada al CCT Mendoza; Argentina. Instituto de Enseñanza Superior 9-011 del Atuel; ArgentinaFil: Rojo, Leandro David. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Museo Municipal de Historia Natural San Rafael - Unidad Asociada al CCT Mendoza; ArgentinaFil: Indiveri, Martina. Gobierno de la Provincia de Mendoza. Hospital Teodoro Schestakow.; ArgentinaFil: Nuñez Sada, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Farina, Lucia. Museo Municipal de Historia Natural San Rafael - Unidad Asociada al CCT Mendoza; ArgentinaFil: Aguilar, Mariano. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Llano, Carina Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Mendoza; ArgentinaFil: Lucero, A.. Universidad de Mendoza; ArgentinaFil: Negreira, Gabriel Alfredo. Instituto de Enseñanza Superior 9-011 del Atuel; ArgentinaFil: Vazquez, Maria Soledad. Universidad Tecnologica Nacional. Facultad Reg.san Rafael. Instituto de Evolucion, Ecologia Historica y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mendoza. Instituto de Evolucion, Ecologia Historica y Ambiente.; ArgentinaFil: Rodriguez, L. F.. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Gallardo, C. A.. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Giraudo, S. B.. Museo Municipal de Historia Natural San Rafael - Unidad Asociada al CCT Mendoza; ArgentinaXIV Encuentro del Centro Internacional de Ciencias de la TierraSan RafaelArgentinaCentro Internacional para Estudios de la TierraComisión Nacional de Energía AtómicaUniversidad Nacional de CuyoUniversidad Tecnológica Nacional. Facultad Regional San Rafae

Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study an international prospective cohort study

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)