The use of rapid prototyping techniques (RPT) to manufacture micro channels suitable for high operation pressures and uPIV

This paper aims to present a new methodology to manufacture micro-channels suitable for high operating pressures and micro particle image velocimetry (µPIV) measurements using a rapid-prototyping high-resolution 3D printer. This methodology can fabricate channels down to 250 µm and withstand pressures of up to 5 ± 0.2 MPa. The manufacturing times are much shorter than in soft lithography processes. The novel manufacturing method developed takes advantage of the recently improved resolution in 3D printers to manufacture an rapid prototyping technique part that contains the hose connections and a micro-channel useful for microfluidics. A method to assemble one wall of the micro-channel using UV curable glue with a glass slide is presented – an operation required to prepare the channel for µPIV measurements. Once built, the micro-channel has been evaluated when working under pressure and the grease flow behavior in it has been measured using µPIV. Furthermore, the minimum achievable channels have been defined using a confocal microscopy study. This technique is much faster than previous micro-manufacturing techniques where different steps were needed to obtain the micro-machined parts. However, due to current 3D printers ' resolutions (around 50 µm) and according to the experimental results, channels smaller than 250-µm2 cross-section should not be used to characterize fluid flow behaviors, as inaccuracies in the channel boundaries can deeply affect the fluid flow behavior. The present methodology is developed due to the need to validate micro-channels using µPIV to lubricate critical components (bearings and gears) in wind turbines. This novel micro-manufacturing technique overcomes current techniques, as it requires less manufacturing steps and therefore it is faster and with less associated costs to manufacture micro-channels down to 250-µm2 cross-section that can withstand pressures higher than 5 MPa that can be used to characterize microfluidic flow behavior using µPIV.Peer ReviewedPostprint (author's final draft

New method for lubricating wind turbine pitch gears using embedded micro-nozzles

This is a copy of the author 's final draft version of an article published in the journal Journal of mechanical science and technology. The final publication is available at Springer via http://dx.doi.org/10.1007/s12206-017-0131-3The increase of power generated by wind turbines has increased the stresses applied in all of its components, thereby causing premature failures. Particularly, pitch and yaw gears suffer from excessive wear mainly caused by inappropriate lubrication. This paper presents a novel method to automatically lubricate the wind turbine pitch gear during operation. A micro-nozzle to inject fresh grease continuously between the teeth in contact was designed, manufactured, and installed in a test bench of a 2 MW wind turbine pitch system. The test bench was used to characterize the fatigue behavior of the gear surface using conventional wind turbine greases under real cyclic loads. Measurements of wear evolution in a pitch gear with and without micro-nozzle show a decrease of 70 % of the wear coefficient after 2×104 cycles.Peer ReviewedPostprint (author's final draft

Chapter 2. The Baix Llobregat (BALL) Demographic Database, between Historical Demography and Computer Vision (nineteenth–twentieth centuries)

The main aims with this book are to compare source materials, databases and research results, as well as creating new opportunities for collaboration in the field of social and population history in the East and the West. All the contributions are based on nominative source material, mainly censuses and vital records, which have been preserved, scanned, transcribed into databases in order to be used for cross-sectional and longitudinal research. The chapters in the first part of this book mostly focus on the construction of nominative databases in Germany, Spain and Romania. The chapters in the second and third part are case studies on the relationship between marriage and fertility; mortality and fertility; marriage behavior and religion; urban mortality; migration, etc. made on the Russian, Austrian, Estonian, Hungarian and Norwegian databases

Tixagevimab–cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial

Background: Tixagevimab–cilgavimab is a neutralising monoclonal antibody combination hypothesised to improve outcomes for patients hospitalised with COVID-19. We aimed to compare tixagevimab–cilgavimab versus placebo, in patients receiving remdesivir and other standard care. Methods: In a randomised, double-blind, phase 3, placebo-controlled trial, adults with symptoms for up to 12 days and hospitalised for COVID-19 at 81 sites in the USA, Europe, Uganda, and Singapore were randomly assigned in a 1:1 ratio to receive intravenous tixagevimab 300 mg–cilgavimab 300 mg or placebo, in addition to remdesivir and other standard care. Patients were excluded if they had acute organ failure including receipt of invasive mechanical ventilation, extracorporeal membrane oxygenation, vasopressor therapy, mechanical circulatory support, or new renal replacement therapy. The study drug was prepared by an unmasked pharmacist; study participants, site study staff, investigators, and clinical providers were masked to study assignment. The primary outcome was time to sustained recovery up to day 90, defined as 14 consecutive days at home after hospital discharge, with co-primary analyses for the full cohort and for participants who were neutralising antibody-negative at baseline. Efficacy and safety analyses were done in the modified intention-to-treat population, defined as participants who received a complete or partial infusion of tixagevimab–cilgavimab or placebo. This study is registered with ClinicalTrials.gov, NCT04501978 and the participant follow-up is ongoing. Findings: From Feb 10 to Sept 30, 2021, 1455 patients were randomly assigned and 1417 in the primary modified intention-to-treat population were infused with tixagevimab–cilgavimab (n=710) or placebo (n=707). The estimated cumulative incidence of sustained recovery was 89% for tixagevimab–cilgavimab and 86% for placebo group participants at day 90 in the full cohort (recovery rate ratio [RRR] 1·08 [95% CI 0·97–1·20]; p=0·21). Results were similar in the seronegative subgroup (RRR 1·14 [0·97–1·34]; p=0·13). Mortality was lower in the tixagevimab–cilgavimab group (61 [9%]) versus placebo group (86 [12%]; hazard ratio [HR] 0·70 [95% CI 0·50–0·97]; p=0·032). The composite safety outcome occurred in 178 (25%) tixagevimab–cilgavimab and 212 (30%) placebo group participants (HR 0·83 [0·68–1·01]; p=0·059). Serious adverse events occurred in 34 (5%) participants in the tixagevimab–cilgavimab group and 38 (5%) in the placebo group. Interpretation: Among patients hospitalised with COVID-19 receiving remdesivir and other standard care, tixagevimab–cilgavimab did not improve the primary outcome of time to sustained recovery but was safe and mortality was lower. Funding: US National Institutes of Health (NIH) and Operation Warp Speed

An Error-Correction Graph Grammar to Recognize Texture Symbols

Revised version of paper presented at the GREC'01 workshop.. Contribution à un ouvrage.This paper presents an algorithm for recognizing symbols with textured elements in a graphical document. A region adjacency graph represents the graphical document. The textured symbols are modeled by a graph grammar. For recognition, a parsing process is applied. Since documents present distortions, error-correcting rules are added to the grammar

New method for lubricating wind turbine pitch gears using embedded micro-nozzles

This is a copy of the author 's final draft version of an article published in the journal Journal of mechanical science and technology. The final publication is available at Springer via http://dx.doi.org/10.1007/s12206-017-0131-3The increase of power generated by wind turbines has increased the stresses applied in all of its components, thereby causing premature failures. Particularly, pitch and yaw gears suffer from excessive wear mainly caused by inappropriate lubrication. This paper presents a novel method to automatically lubricate the wind turbine pitch gear during operation. A micro-nozzle to inject fresh grease continuously between the teeth in contact was designed, manufactured, and installed in a test bench of a 2 MW wind turbine pitch system. The test bench was used to characterize the fatigue behavior of the gear surface using conventional wind turbine greases under real cyclic loads. Measurements of wear evolution in a pitch gear with and without micro-nozzle show a decrease of 70 % of the wear coefficient after 2×104 cycles.Peer Reviewe