On the Threshold of Intractability

We study the computational complexity of the graph modification problems Threshold Editing and Chain Editing, adding and deleting as few edges as possible to transform the input into a threshold (or chain) graph. In this article, we show that both problems are NP-complete, resolving a conjecture by Natanzon, Shamir, and Sharan (Discrete Applied Mathematics, 113(1):109--128, 2001). On the positive side, we show the problem admits a quadratic vertex kernel. Furthermore, we give a subexponential time parameterized algorithm solving Threshold Editing in $2^{O(\surd k \log k)} + \text{poly}(n)$ time, making it one of relatively few natural problems in this complexity class on general graphs. These results are of broader interest to the field of social network analysis, where recent work of Brandes (ISAAC, 2014) posits that the minimum edit distance to a threshold graph gives a good measure of consistency for node centralities. Finally, we show that all our positive results extend to the related problem of Chain Editing, as well as the completion and deletion variants of both problems

Scaling and memory in the return intervals of energy dissipation rate in three-dimensional fully developed turbulence

We study the statistical properties of return intervals $r$ between successive energy dissipation rates above a certain threshold $Q$ in three-dimensional fully developed turbulence. We find that the distribution function $P_Q(r)$ scales with the mean return interval $R_Q$ as $P_Q(r)=R_Q^{-1}f(r/R_Q)$ except for $r=1$, where the scaling function $f(x)$ has two power-law regimes. The return intervals are short-term and long-term correlated and possess multifractal nature. The Hurst index of the return intervals decays exponentially against $R_Q$, predicting that rare extreme events with $R_Q\to\infty$ are also long-term correlated with the Hurst index $H_\infty=0.639$.Comment: 5 pages, 5 figure

The role of biomimetic hypoxia on cancer cell behaviour in 3d models: A systematic review

The development of biomimetic, human tissue models is recognized as being an important step for transitioning in vitro research findings to the native in vivo response. Oftentimes, 2D models lack the necessary complexity to truly recapitulate cellular responses. The introduction of physiological features into 3D models informs us of how each component feature alters specific cellular response. We conducted a systematic review of research papers where the focus was the introduction of key biomimetic features into in vitro models of cancer, including 3D culture and hypoxia. We analysed outcomes from these and compiled our findings into distinct groupings to ascertain which biomimetic parameters correlated with specific responses. We found a number of biomimetic features which primed cancer cells to respond in a manner which matched in vivo response

Effects of quantum space time foam in the neutrino sector

We discuss violations of CPT and quantum mechanics due to interactions of neutrinos with space-time quantum foam. Neutrinoless double beta decay and oscillations of neutrinos from astrophysical sources (supernovae, active galactic nuclei) are analysed. It is found that the propagation distance is the crucial quantity entering any bounds on EHNS parameters. Thus, while the bounds from neutrinoless double beta decay are not significant, the data of the supernova 1987a imply a bound being several orders of magnitude more stringent than the ones known from the literature. Even more stringent limits may be obtained from the investigation of neutrino oscillations from active galactic nuclei sources, which have an impressive potential for the search of quantum foam interactions in the neutrino sector.Comment: 5 page

Crosses with Amut Bmut homokaryons of Coprinus cinereus

In this paper we describe the initial genetic analysis of some developmental REMI and UV mutants of the self-compatible homokaryon Amut Bmut. We show that such homokaryons can mate with each other although in fruitbodies we often found spores of only one parent. Crosses with monokaryons of different mating types gave some indications about numbers of mutations and linkage of genetic markers. In most cases, however, we observed an uneven distribution of markers, most likely because of loss of certain progeny. Our results necessitate the construction of monokaryons as closely related to homokaryon AmutBmut as possible but with different mating type loci

Robustness of Sound Speed and Jet Quenching for Gauge/Gravity Models of Hot QCD

We probe the effectiveness and robustness of a simple gauge/gravity dual model of the QCD fireball that breaks conformal symmetry by constructing a family of similar geometries that solve the scalar/gravity equations of motion. This family has two parameters, one of which is associated to the temperature. We calculate two quantities, the speed of sound and the jet-quenching parameter. We find the speed of sound to be universal and robust over all the geometries when appropriate units are used, while the jet-quenching parameter varies significantly away from the conformal limit. We note that the overall structure of the jet-quenching depends strongly on whether the running scalar is the dilaton or not. We also discuss the variation of the scalar potential over our family of solutions, and truncate our results to where the associated error is small.Comment: 21 pages, 9 figures, LaTeX. v2:references added, minor correction to speed of sound; conclusions unchange

Protein O-Mannosylation in the Murine Brain: Occurrence of Mono-O-Mannosyl Glycans and Identification of New Substrates

Protein O-mannosylation is a post-translational modification essential for correct development of mammals. In humans, deficient O-mannosylation results in severe congenital muscular dystrophies often associated with impaired brain and eye development. Although various O-mannosylated proteins have been identified in the recent years, the distribution of O-mannosyl glycans in the mammalian brain and target proteins are still not well defined. In the present study, rabbit monoclonal antibodies directed against the O-mannosylated peptide YAT(α1-Man)AV were generated. Detailed characterization of clone RKU-1-3-5 revealed that this monoclonal antibody recognizes O-linked mannose also in different peptide and protein contexts. Using this tool, we observed that mono-O-mannosyl glycans occur ubiquitously throughout the murine brain but are especially enriched at inhibitory GABAergic neurons and at the perineural nets. Using a mass spectrometry-based approach, we further identified glycoproteins from the murine brain that bear single O-mannose residues. Among the candidates identified are members of the cadherin and plexin superfamilies and the perineural net protein neurocan. In addition, we identified neurexin 3, a cell adhesion protein involved in synaptic plasticity, and inter-alpha-trypsin inhibitor 5, a protease inhibitor important in stabilizing the extracellular matrix, as new O-mannosylated glycoproteins

Online Determination of Graphene Lattice Orientation Through Lateral Forces

Rapid progress in graphene engineering has called for a simple and effective method to determine the lattice orientation on graphene before tailoring graphene to the desired edge structures and shapes. In this work, a wavelet transform-based frequency identification method is developed to distinguish the lattice orientation of graphene. The lattice orientation is determined through the different distribution of the frequency power spectrum just from a single scan line. This method is proven both theoretically and experimentally to be useful and controllable. The results at the atomic scale show that the frequencies vary with the lattice orientation of graphene. Thus, an adjusted angle to the desired lattice orientation (zigzag or armchair) can easily be calculated based on the frequency obtained from the single scan line. Ultimately, these results will play a critical role in wafer-size graphene engineering and in the manufacturing of graphene-based nanodevices.published_or_final_versio

Responses of quark condensates to the chemical potential

The responses of quark condensates to the chemical potential, as a function of temperature T and chemical potential \mu, are calculated within the Nambu--Jona-Lasinio (NJL) model. We compare our results with those from the recent lattice QCD simulations [QCD-TARO Collaboration, Nucl. Phys. B (Proc. Suppl.) 106, 462 (2002)]. The NJL model and lattice calculations show qualitatively similar behavior, and they will be complimentary ways to study hadrons at finite density. The behavior above T_c requires more elaborated analyses.Comment: 3 pages, 2 figs, based on a contribution to the Prof. Osamu Miyamura memorial symposium, Hiroshima University, Nov. 16-17, 2001; slightly revised, accepted for publication in Physical Review