4,062 research outputs found
Square patterns in Rayleigh-Benard convection with rotation about a vertical axis
We present experimental results for Rayleigh-Benard convection with rotation
about a vertical axis at dimensionless rotation rates in the range 0 to 250 and
upto 20% above the onset. Critical Rayleigh numbers and wavenumbers agree with
predictions of linear stability analysis. For rotation rates greater than 70
and close to onset, the patterns are cellular with local four-fold coordination
and differ from the theoretically expected Kuppers-Lortz unstable state. Stable
as well as intermittent defect-free square lattices exist over certain
parameter ranges. Over other ranges defects dynamically disrupt the lattice but
cellular flow and local four-fold coordination is maintained.Comment: ReVTeX, 4 pages, 7 eps figures include
Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer\u27s disease
Interest in understanding the roles of white matter (WM) inflammation and damage in the pathophysiology of Alzheimer disease (AD) has been growing significantly in recent years. However, in vivo magnetic resonance imaging (MRI) techniques for imaging inflammation are still lacking. An advanced diffusion-based MRI method, neuro-inflammation imaging (NII), has been developed to clinically image and quantify WM inflammation and damage in AD. Here, we employed NII measures in conjunction with cerebrospinal fluid (CSF) biomarker classification (for ÎČ-amyloid (AÎČ) and neurodegeneration) to evaluate 200 participants in an ongoing study of memory and aging. Elevated NII-derived cellular diffusivity was observed in both preclinical and early symptomatic phases of AD, while disruption of WM integrity, as detected by decreased fractional anisotropy (FA) and increased radial diffusivity (RD), was only observed in the symptomatic phase of AD. This may suggest that WM inflammation occurs earlier than WM damage following abnormal AÎČ accumulation in AD. The negative correlation between NII-derived cellular diffusivity and CSF AÎČ42 level (a marker of amyloidosis) may indicate that WM inflammation is associated with increasing AÎČ burden. NII-derived FA also negatively correlated with CSF t-tau level (a marker of neurodegeneration), suggesting that disruption of WM integrity is associated with increasing neurodegeneration. Our findings demonstrated the capability of NII to simultaneously image and quantify WM cellularity changes and damage in preclinical and early symptomatic AD. NII may serve as a clinically feasible imaging tool to study the individual and composite roles of WM inflammation and damage in AD. Keywords: Inflammation, White matter damage, Diffusion basis spectrum imaging, Neuro-inflammation imaging, Cerebrospinal fluid, Preclinical Alzheimer disease, Early symptomatic Alzheimer disease, Magnetic resonance imagin
Mechanism of efficient anti-Markovnikov olefin hydroarylation catalyzed by homogeneous Ir(III) complexes
The mechanism of the hydroarylation reaction between unactivated olefins (ethylene, propylene, and styrene) and benzene catalyzed by [(R)Ir(ÎŒ-acac-O,O,C^3)-(acac-O,O)_2]_2 and [R-Ir(acac-O,O)_2(L)] (R = acetylacetonato, CH_3, CH_2CH_3, Ph, or CH_2CH_2Ph, and L = H_2O or pyridine) Ir(III) complexes was studied by experimental methods. The system is selective for generating the anti-Markovnikov product of linear alkylarenes (61 : 39 for benzene + propylene and 98 : 2 for benzene + styrene). The reaction mechanism was found to follow a rate law with first-order dependence on benzene and catalyst, but a non-linear dependence on olefin. ^(13)C-labelling studies with CH_3^(13)CH_2-Ir-Py showed that reversible ÎČ-hydride elimination is facile, but unproductive, giving exclusively saturated alkylarene products. The migration of the ^(13)C-label from the α to ÎČ-positions was found to be slower than the CâH activation of benzene (and thus formation of ethane and Ph-d_5-Ir-Py). Kinetic analysis under steady state conditions gave a ratio of the rate constants for CH activation and ÎČ-hydride elimination (k_(CH): k_ÎČ) of 0.5. The comparable magnitude of these rates suggests a common rate determining transition state/intermediate, which has been shown previously with B3LYP density functional theory (DFT) calculations. Overall, the mechanism of hydroarylation proceeds through a series of pre-equilibrium dissociative steps involving rupture of the dinuclear species or the loss of L from Ph-Ir-L to the solvento, 16-electron species, Ph-Ir(acac-O,O)_2-Sol (where Sol refers to coordinated solvent). This species then undergoes trans to cis isomerization of the acetylacetonato ligand to yield the pseudo octahedral species cis-Ph-Ir-Sol, which is followed by olefin insertion (the regioselective and rate determining step), and then activation of the CâH bond of an incoming benzene to generate the product and regenerate the catalyst
Analysis of the Type IIn Supernova 1998S: Effects of Circumstellar Interaction on Observed Spectra
We present spectral analysis of early observations of the Type IIn supernova
1998S using the general non-local thermodynamic equilibrium atmosphere code \tt
PHOENIX}. We model both the underlying supernova spectrum and the overlying
circumstellar interaction region and produce spectra in good agreement with
observations. The early spectra are well fit by lines produced primarily in the
circumstellar region itself, and later spectra are due primarily to the
supernova ejecta. Intermediate spectra are affected by both regions. A
mass-loss rate of order \msol yr is inferred
for a wind speed of 100-1000 \kmps. We discuss how future self-consistent
models will better clarify the underlying progenitor structure.Comment: to appear in ApJ, 2001, 54
Comparison of embedded and added motor imagery training in patients after stroke: Results of a randomised controlled pilot trial
Copyright @ 2012 Schuster et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background: Motor imagery (MI) when combined with physiotherapy can offer functional benefits after stroke. Two MI integration strategies exist: added and embedded MI. Both approaches were compared when learning a complex motor task (MT): âGoing down, laying on the floor, and getting up againâ. Methods: Outpatients after first stroke participated in a single-blinded, randomised controlled trial with MI embedded into physiotherapy (EG1), MI added to physiotherapy (EG2), and a control group (CG). All groups participated in six physiotherapy sessions. Primary study outcome was time (sec) to perform the motor task at pre and post-intervention. Secondary outcomes: level of help needed, stages of MT-completion, independence, balance, fear of falling (FOF), MI ability. Data were collected four times: twice during one week baseline phase (BL, T0), following the two week intervention (T1), after a two week follow-up (FU). Analysis of variance was performed. Results: Thirty nine outpatients were included (12 females, age: 63.4 ± 10 years; time since stroke: 3.5 ± 2 years; 29 with an ischemic event). All were able to complete the motor task using the standardised 7-step procedure and reduced FOF at T0, T1, and FU. Times to perform the MT at baseline were 44.2 ± 22s, 64.6 ± 50s, and 118.3 ± 93s for EG1 (N = 13), EG2 (N = 12), and CG (N = 14). All groups showed significant improvement in time to complete the MT (p < 0.001) and degree of help needed to perform the task: minimal assistance to supervision (CG) and independent performance (EG1+2). No between group differences were found. Only EG1 demonstrated changes in MI ability over time with the visual indicator increasing from T0 to T1 and decreasing from T1 to FU. The kinaesthetic indicator increased from T1 to FU. Patients indicated to value the MI training and continued using MI for other difficult-to-perform tasks. Conclusions: Embedded or added MI training combined with physiotherapy seem to be feasible and benefi-cial to learn the MT with emphasis on getting up independently. Based on their baseline level CG had the highest potential to improve outcomes. A patient study with 35 patients per group could give a conclusive answer of a superior MI integration strategy.The research project was partially funded by the Gottfried und Julia Bangerter-Rhyner Foundation
Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids.
Drosophila phototransduction is mediated via a G-protein-coupled PLC cascade. Recent evidence, including the demonstration that light evokes rapid contractions of the photoreceptors, suggested that the light-sensitive channels (TRP and TRPL) may be mechanically gated, together with protons released by PLC-mediated PIP2 hydrolysis. If mechanical gating is involved we predicted that the response to light should be influenced by altering the physical properties of the membrane. To achieve this, we used diet to manipulate the degree of saturation of membrane phospholipids. In flies reared on a yeast diet, lacking polyunsaturated fatty acids (PUFAs), mass spectrometry showed that the proportion of polyunsaturated phospholipids was sevenfold reduced (from 38 to âŒ5%) but rescued by adding a single species of PUFA (linolenic or linoleic acid) to the diet. Photoreceptors from yeast-reared flies showed a 2- to 3-fold increase in latency and time to peak of the light response, without affecting quantum bump waveform. In the absence of Ca(2+) influx or in trp mutants expressing only TRPL channels, sensitivity to light was reduced up to âŒ10-fold by the yeast diet, and essentially abolished in hypomorphic G-protein mutants (Gαq). PLC activity appeared little affected by the yeast diet; however, light-induced contractions measured by atomic force microscopy or the activation of ectopic mechanosensitive gramicidin channels were also slowed âŒ2-fold. The results are consistent with mechanosensitive gating and provide a striking example of how dietary fatty acids can profoundly influence sensory performance in a classical G-protein-coupled signaling cascade.This research was supported by the Biotechnology and Biological Sciences Research Council (BBSRC; to M.J.O.W. and Q.Z., BBSRC Grant BB/G006865/1 to R.C.H., BB/H013849/1 to M.J., and BBSRC doctoral awards to A.S.R. and S.A.D.), the State Key Laboratory of Cognitive Neuroscience and Learning Open Research Fund (to M.J.), Jane and Aatos Erkko Foundation Fellowship (to M.J.), the Leverhulme Trust Grant (RPG-2012-567 to M.J.), and the UK Medical Research Council (Career Development Award to K.F.).This is the final published version of the article, originally published in the Journal of Neuroscience, February 11, 2015, 35(6): 2731â2746, DOI: 10.1523/JNEUROSCI.1150-14.201
Experimental demonstration of quantum memory for light
The information carrier of today's communications, a weak pulse of light, is
an intrinsically quantum object. As a consequence, complete information about
the pulse cannot, even in principle, be perfectly recorded in a classical
memory. In the field of quantum information this has led to a long standing
challenge: how to achieve a high-fidelity transfer of an independently prepared
quantum state of light onto the atomic quantum state? Here we propose and
experimentally demonstrate a protocol for such quantum memory based on atomic
ensembles. We demonstrate for the first time a recording of an externally
provided quantum state of light onto the atomic quantum memory with a fidelity
up to 70%, significantly higher than that for the classical recording. Quantum
storage of light is achieved in three steps: an interaction of light with
atoms, the subsequent measurement on the transmitted light, and the feedback
onto the atoms conditioned on the measurement result. Density of recorded
states 33% higher than that for the best classical recording of light on atoms
is achieved. A quantum memory lifetime of up to 4 msec is demonstrated.Comment: 22 pages (double line spacing) incl. supplementary information, 4
figures, accepted for publication in Natur
Polygenic scores for smoking and educational attainment have independent influences on academic success and adjustment in adolescence and educational attainment in adulthood
23 High Redshift Supernovae from the IfA Deep Survey: Doubling the SN Sample at z>0.7
We present photometric and spectroscopic observations of 23 high redshift
supernovae spanning a range of z=0.34-1.03, 9 of which are unambiguously
classified as Type Ia. These supernovae were discovered during the IfA Deep
Survey, which began in September 2001 and observed a total of 2.5 square
degrees to a depth of approximately m=25-26 in RIZ over 9-17 visits, typically
every 1-3 weeks for nearly 5 months, with additional observations continuing
until April 2002. We give a brief description of the survey motivations,
observational strategy, and reduction process. This sample of 23 high-redshift
supernovae includes 15 at z>0.7, doubling the published number of objects at
these redshifts, and indicates that the evidence for acceleration of the
universe is not due to a systematic effect proportional to redshift. In
combination with the recent compilation of Tonry et al. (2003), we calculate
cosmological parameter density contours which are consistent with the flat
universe indicated by the CMB (Spergel et al. 2003). Adopting the constraint
that Omega_total = 1.0, we obtain best-fit values of (Omega_m,
Omega_Lambda)=(0.33, 0.67) using 22 SNe from this survey augmented by the
literature compilation. We show that using the empty-beam model for
gravitational lensing does not eliminate the need for Omega_Lambda > 0.
Experience from this survey indicates great potential for similar large-scale
surveys while also revealing the limitations of performing surveys for z>1 SNe
from the ground.Comment: 67 pages, 12 figures, 12 tables, accepted for publication in the
Astrophysical Journa
The Affective Impact of Financial Skewness on Neural Activity and Choice
Few finance theories consider the influence of âskewnessâ (or large and asymmetric but unlikely outcomes) on financial choice. We investigated the impact of skewed gambles on subjects' neural activity, self-reported affective responses, and subsequent preferences using functional magnetic resonance imaging (FMRI). Neurally, skewed gambles elicited more anterior insula activation than symmetric gambles equated for expected value and variance, and positively skewed gambles also specifically elicited more nucleus accumbens (NAcc) activation than negatively skewed gambles. Affectively, positively skewed gambles elicited more positive arousal and negatively skewed gambles elicited more negative arousal than symmetric gambles equated for expected value and variance. Subjects also preferred positively skewed gambles more, but negatively skewed gambles less than symmetric gambles of equal expected value. Individual differences in both NAcc activity and positive arousal predicted preferences for positively skewed gambles. These findings support an anticipatory affect account in which statistical properties of gamblesâincluding skewnessâcan influence neural activity, affective responses, and ultimately, choice
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