Design investigations on some welded mild steel plate girders

The thesis gives details of a series of design investigations carried out on mild steel, welded, plate girders, having a constant I section and supported laterally and torsionally only at the ends of the span. The main aim is to establish a General Method for expediting the design calculations for obtaining the optimum cross sectional dimensions of such a girder, essentially in accordance with the regulations as laid down in the British Standard Specification (B.S.449, while observing some rules for efficient or economical design. Here Minimum Weight Design has been chosen as the criterion of efficiency, though the methods devised can readily be extended or adapted to deal with other criteria. The moment of resistance, as reduced by lateral buckling, is deemed to be the significant factor in each design, though the various other effects are considered as well. A review of the problem is given, and an empirical investigation is then carried out to obtain the sectional dimensions of girders at Minimum Weight, spanning 100 feet, and resisting various moments. This work is then extended to a wider application by means of a theoretical analysis, and a General Method is obtained. Suggestions are made as to how this Method may be applied, viz: by the construction of charts and tables or by the writing of an all embracing computer programme to give automatic design. Various additional effects are described and finally an outline is given as to how this work can be extended to deal with more complicated practical girders

Oscillation Amplitude Growth for a Decelerating Object with Constant Pitch Damping

The equations governing the deceleration and oscillation of a blunt body moving along a planar trajectory are re-expressed in the form of the Euler-Cauchy equation. An analytic solution of this equation describes the oscillation amplitude growth and frequency dilation with time for a statically stable decelerating body with constant pitch damping. The oscillation histories for several constant pitch damping values, predicted by the solution of the Euler-Cauchy equation are compared to POST six degree-of-freedom (6-DoF) trajectory simulations. The simulations use simplified aerodynamic coefficients matching the Euler-Cauchy approximations. Agreement between the model predictions and simulation results are excellent. Euler-Cauchy curves are also fit through nonlinear 6-DoF simulations and ballistic range data to identify static stability and pitch damping coefficients. The model os shown to closely fit through the data points and capture the behavior of the blunt body observed in simulation and experiment. The extracted coefficients are in reasonable agreement with higher fidelity, nonlinear parameter identification results. Finally, a nondimensional version of the Euler-Cauchy equation is presented and shown to be a simple and effective tool for designing dynamically scaled experiments for decelerating blunt capsule flight

Progress in Payload Separation Risk Mitigation for a Deployable Venus Heat Shield

A deployable decelerator known as the Adaptive Deployable Entry and Placement Technology (ADEPT) offers substantial science and mass savings for the Venus In Situ Explorer (VISE) mission. The lander and science payload must be separated from ADEPT during atmospheric entry. This paper presents a trade study of the separation system concept of operations and provides a conceptual design of the baseline: aft-separation with a subsonic parachute. Viability of the separation system depends on the vehicle's dynamic stability characteristics during deceleration from supersonic to subsonic speeds. A trajectory sensitivity study presented shows that pitch damping and Venusian winds drive stability prior to parachute deployment, while entry spin rate is not a driver of stability below Mach 5. Additionally, progress in free-flight CFD techniques capable of computing aerodynamic damping parameters is presented. Exploratory simulations of ADEPT at a constant speed of Mach number of 0.8 suggest the vehicle may have an oscillation limit cycle near 5 angle-of-attack. The proposed separation system conceptual design is thought to be viable

Enhancing reuse of data and biological material in medical research : from FAIR to FAIR-Health

The known challenge of underutilization of data and biological material from biorepositories as potential resources formedical research has been the focus of discussion for over a decade. Recently developed guidelines for improved data availability and reusability—entitled FAIR Principles (Findability, Accessibility, Interoperability, and Reusability)—are likely to address only parts of the problem. In this article,we argue that biologicalmaterial and data should be viewed as a unified resource. This approach would facilitate access to complete provenance information, which is a prerequisite for reproducibility and meaningful integration of the data. A unified view also allows for optimization of long-term storage strategies, as demonstrated in the case of biobanks.Wepropose an extension of the FAIR Principles to include the following additional components: (1) quality aspects related to research reproducibility and meaningful reuse of the data, (2) incentives to stimulate effective enrichment of data sets and biological material collections and its reuse on all levels, and (3) privacy-respecting approaches for working with the human material and data. These FAIR-Health principles should then be applied to both the biological material and data. We also propose the development of common guidelines for cloud architectures, due to the unprecedented growth of volume and breadth of medical data generation, as well as the associated need to process the data efficiently.peer-reviewe

LifeGene : a large prospective population-based study of global relevance

Studying gene-environment interactions requires that the amount and quality of the lifestyle data is comparable to what is available for the corresponding genomic data. Sweden has several crucial prerequisites for comprehensive longitudinal biomedical research, such as the personal identity number, the universally available national health care system, continuously updated population and health registries and a scientifically motivated population. LifeGene builds on these strengths to bridge the gap between basic research and clinical applications with particular attention to populations, through a unique design in a research-friendly setting. LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18-45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre-and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants' age and life events. The target of LifeGene is to enroll 500,000 Swedes and follow them longitudinally for at least 20 years.Stockholm County CouncilVetenskapsrådetKarolinska InstitutetTorsten and Ragnar Söderbergs FoundationAFA FörsäkringarManuscrip

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research

A wealth of biospecimen samples are stored in modern globally distributed biobanks. Biomedical researchers worldwide need to be able to combine the available resources to improve the power of large-scale studies. A prerequisite for this effort is to be able to search and access phenotypic, clinical and other information about samples that are currently stored at biobanks in an integrated manner. However, privacy issues together with heterogeneous information systems and the lack of agreed-upon vocabularies have made specimen searching across multiple biobanks extremely challenging. We describe three case studies where we have linked samples and sample descriptions in order to facilitate global searching of available samples for research. The use cases include the ENGAGE (European Network for Genetic and Genomic Epidemiology) consortium comprising at least 39 cohorts, the SUMMIT (surrogate markers for micro- and macro-vascular hard endpoints for innovative diabetes tools) consortium and a pilot for data integration between a Swedish clinical health registry and a biobank. We used the Sample avAILability (SAIL) method for data linking: first, created harmonised variables and then annotated and made searchable information on the number of specimens available in individual biobanks for various phenotypic categories. By operating on this categorised availability data we sidestep many obstacles related to privacy that arise when handling real values and show that harmonised and annotated records about data availability across disparate biomedical archives provide a key methodological advance in pre-analysis exchange of information between biobanks, that is, during the project planning phase

Food Insecurity Prevalence Across Diverse Sites During COVID-19: A Year of Comprehensive Data

Key Findings NFACT includes 18 study sites in 15 states as well as a national poll, collectively representing a sample size of more than 26,000 people. Some sites have implemented multiple survey rounds, here we report results from 22 separate surveys conducted during the year since the COVID-19 pandemic began in March 2020. 18 out of 19 surveys in 14 sites with data for before and since the pandemic began found an increase in food insecurity since the start of the COVID-19 pandemic as compared to before the pandemic. In nearly all surveys (18/19) that measured food insecurity both before and during the pandemic, more Black, Indigenous, and People of Color (BIPOC) were classified as food insecure during the pandemic as compared to before it began. Prevalence of food insecurity for BIPOC respondents was higher than the overall population in the majority of surveys (19/20) sampling a general population. In almost all surveys (21/22), the prevalence of food insecurity for households with children was higher than the overall prevalence of food insecurity. Food insecurity prevalence was higher for households experiencing a negative job impact during the pandemic (i.e. job loss, furlough, reduction in hours) in nearly all surveys and study sites (21/22). Food insecurity prevalence in most sites was significantly higher before COVID-19 than estimates from that time period. Reporting a percent change between pre and during COVID-19 prevalence may provide additional information about the rate of change in food insecurity since the start of the pandemic, which absolute prevalence of food insecurity may not capture. Results highlight consistent trends in food insecurity outcomes since the start of the COVID-19 pandemic, across diverse study sites, methodological approaches, and time