An understanding of ejector flow phenomena for waste heat driven cooling

In an attempt to reduce the dependence on fossil fuels, a variety of research initiatives has focused on increasing the efficiency of conventional energy systems. One such approach is to use waste heat recovery to reclaim energy that is typically lost in the form of dissipative heat. An example of such reclamation is the use of waste heat recovery systems that take low-temperature heat and deliver cooling in space-conditioning applications. In this work, an ejector-based chiller driven by waste heat will be studied from the system to component to sub-component levels, with a specific focus on the ejector. The ejector is a passive device used to compress refrigerants in waste heat driven heat pumps without the use of high grade electricity or wear-prone complex moving parts. With such ejectors, the electrical input for the overall system can be reduced or eliminated entirely under certain conditions, and package sizes can be significantly reduced, allowing for a cooling system that can operate in off-grid, mobile, or remote applications. The performance of this system, measured typically as a coefficient of performance, is primarily dependent on the performance of the ejector pump. This work uses analytical and numerical modeling techniques combined with flow visualization to determine the exact mechanisms of ejector operation, and makes suggestions for ejector performance improvement. Specifically, forcing the presence of two-phase flow has been suggested as a potential tool for performance enhancement. This study determines the effect of two-phase flow on momentum transfer characteristics inside the ejector while operating with refrigerants R134a and R245fa. It is found that reducing the superheat at motive nozzle inlet results in a 12-13% increase in COP with a 14-16 K decrease in driving waste heat temperature. The mechanisms of this improvement are found to be a combination of two effects: the choice of operating fluid (wet vs. dry) and the effect of two-phase flow on the effectiveness of momentum transfer. It is recommended that ejector-based chillers be operated such that the motive nozzle inlet is near saturation, and environmentally friendly dry fluids such as R245fa be used to improve performance. This work provides critical methods for ejector modeling and validation through visualization, as well as guidance on measures to improve ejector design with commensurate beneficial effects on cooling system COP.Ph.D

Probiotics for preventing acute otitis media in children

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: to assess the effects of probiotics to prevent the occurrence and reduce the severity of acute otitis media in children.</p

Bloch Analysis of Finite Periodic Microring Chains

We apply Bloch analysis to the study of finite periodic cascading of microring resonators. Diagonalization of the standard transfer matrix approach not only allows to find an exact analytic expression for transmission and reflection, but also to derive a closed form solution for the field in every point of the structure. To give more physical insight we analyze the main features of the transmission resonances in a finite chain and we give some hints for their experimental verificationComment: 19 pages, 4 figure

Higher-order optical resonance node detection of integrated disk microresonator

We have demonstrated higher-order optical resonance node detection by using an integrated disk microresonator from through port of the coupling bus waveguide. In addition to the fundamental mode, the disk resonator has higher-order whispering gallery modes. The excited second-order higher-order mode has a node at the position where the electromagnetic energy of the fundamental mode is close to a maximum. This high resolution measurement of optical resonance mode profile has a variety of applications for optical sensing and detection. The self-referencing characteristics of the two optical resonance modes have potential to achieve optical detection independent of external perturbation, such as temperature change

Parental and clinician agreement of illness severity in children with RTIs:Secondary analysis of data from a prospective cohort study

Background: severity assessments of respiratory tract infection (RTI) in children are known to differ between parents and clinicians, but determinants of perceived severity are unknown. Aim: to investigate the (dis)agreement between, and compare the determinants of, parent and clinician severity scores. Design and setting: secondary analysis of data from a prospective cohort study of 8394 children presenting to primary care with acute (≤28 days) cough and RTI. Method: data on sociodemographic factors, parent-reported symptoms, clinician-reported findings, and severity assessments were used. Kappa (κ)-statistics were used to investigate (dis) agreement, whereas multivariable logistic regression was used to identify the factors associated with illness severity. Results: parents reported higher illness severity (mean 5.2 [standard deviation (SD) 1.8], median 5 [interquartile range (IQR) 4–7]), than clinicians (mean 3.1 [SD 1.7], median 3 [IQR 2–4], P&lt;0.0001). There was low positive correlation between these scores (+0.43) and poor inter-rater agreement between parents and clinicians (κ 0.049). The number of clinical signs was highly correlated with clinician scores (+0.71). Parent-reported symptoms (in the previous 24 hours) that were independently associated with higher illness severity scores, in order of importance, were: severe fever, severe cough, rapid breathing, severe reduced eating, moderate-to-severe reduced fluid intake, severe disturbed sleep, and change in cry. Three of these symptoms (severe fever, rapid breathing, and change in cry) along with inter/ subcostal recession, crackles/crepitations, nasal flaring, wheeze, and drowsiness/irritability were associated with higher clinician scores. Conclusion: clinicians and parents use different factors and make different judgements about the severity of children’s RTI. Improved understanding of the factors that concern parents could improve parent–clinician communication and consultation outcomes.</p

Impact of antibiotics for children presenting to general practice with cough on adverse outcomes: secondary analysis from a multicentre prospective cohort study

BACKGROUND: Clinicians commonly prescribe antibiotics to prevent major adverse outcomes in children presenting in primary care with cough and respiratory symptoms, despite limited meaningful evidence of impact on these outcomes. AIM: To estimate the effect of children's antibiotic prescribing on adverse outcomes within 30 days of initial consultation. DESIGN AND SETTING: Secondary analysis of 8320 children in a multicentre prospective cohort study, aged 3 months to <16 years, presenting in primary care across England with acute cough and other respiratory symptoms. METHOD: Baseline clinical characteristics and antibiotic prescribing data were collected, and generalised linear models were used to estimate the effect of antibiotic prescribing on adverse outcomes within 30 days (subsequent hospitalisations and reconsultation for deterioration), controlling for clustering and clinicians' propensity to prescribe antibiotics. RESULTS: Sixty-five (0.8%) children were hospitalised and 350 (4%) reconsulted for deterioration. Clinicians prescribed immediate and delayed antibiotics to 2313 (28%) and 771 (9%), respectively. Compared with no antibiotics, there was no clear evidence that antibiotics reduced hospitalisations (immediate antibiotic risk ratio [RR] 0.83, 95% confidence interval [CI] = 0.47 to 1.45; delayed RR 0.70, 95% CI = 0.26 to 1.90, overall P = 0.44). There was evidence that delayed (rather than immediate) antibiotics reduced reconsultations for deterioration (immediate RR 0.82, 95% CI = 0.65 to 1.07; delayed RR 0.55, 95% CI = 0.34 to 0.88, overall P = 0.024). CONCLUSION: Most children presenting with acute cough and respiratory symptoms in primary care are not at risk of hospitalisation, and antibiotics may not reduce the risk. If an antibiotic is considered, a delayed antibiotic prescription may be preferable as it is likely to reduce reconsultation for deterioration

An extended relational document retrieval model

Relational Data Base Management Systems offer a commercially available tool with which to build effective document retrieval systems. The full potential of the relational model for supporting the kind of ad hoc inquiry characteristic of document retrieval has only recently been explored. In addition, commercially available relational DBMS's also provide effective tools for managing document data bases by providing facilities for, inter alia, concurrency control, data migration and reorganization routines, authorization mechanisms, enforcement of integrity constraints, dynamic data definition, etc. This article will present a relational logical model to support a sophisticated document retrieval system in which flexible forms of inferential and associative searching can be performed. Examples of ad hoc inquiry will be presented in SQL. Several problems of particular importance to document retrieval will be discussed, including the importance of Conjunctive Normal Form in query formulation, unique aspects of document retrieval storage and processing overhead, and techniques for reducing the size of storage without severely impacting retrieval effectiveness.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27543/1/0000587.pd

What gives rise to clinician gut feeling, its influence on management decisions and its prognostic value for children with RTI in primary care: a prospective cohort study.

BACKGROUND: The objectives were to identify 1) the clinician and child characteristics associated with; 2) clinical management decisions following from, and; 3) the prognostic value of; a clinician's 'gut feeling something is wrong' for children presenting to primary care with acute cough and respiratory tract infection (RTI). METHODS: Multicentre prospective cohort study where 518 primary care clinicians across 244 general practices in England assessed 8394 children aged ≥3 months and < 16 years for acute cough and RTI. The main outcome measures were: Self-reported clinician 'gut feeling'; clinician management decisions (antibiotic prescribing, referral for acute admission); and child's prognosis (reconsultation with evidence of illness deterioration, hospital admission in the 30 days following recruitment). RESULTS: Clinician years since qualification, parent reported symptoms (illness severity score ≥ 7/10, severe fever < 24 h, low energy, shortness of breath) and clinical examination findings (crackles/ crepitations on chest auscultation, recession, pallor, bronchial breathing, wheeze, temperature ≥ 37.8 °C, tachypnoea and inflamed pharynx) independently contributed towards a clinician 'gut feeling that something was wrong'. 'Gut feeling' was independently associated with increased antibiotic prescribing and referral for secondary care assessment. After adjustment for other associated factors, gut feeling was not associated with reconsultations or hospital admissions. CONCLUSIONS: Clinicians were more likely to report a gut feeling something is wrong, when they were more experienced or when children were more unwell. Gut feeling is independently and strongly associated with antibiotic prescribing and referral to secondary care, but not with two indicators of poor child health

Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos, a Common Agricultural Pesticide

Background: In a longitudinal birth cohort study of inner-city mothers and children (Columbia Center for Children’s Environmental Health), we have previously reported that prenatal exposure to chlorpyrifos (CPF) was associated with neurodevelopmental problems at 3 years of age

Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation

The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Deletion of a gene encoding a putative deacetylase, Agd3, leads to defects in GAG deacetylation, biofilm formation, and virulence. Here, we show that Agd3 deacetylates GAG in a metal-dependent manner, and is the founding member of carbohydrate esterase family CE18. The active site is formed by four catalytic motifs that are essential for activity. The structure of Agd3 includes an elongated substrate-binding cleft formed by a carbohydrate binding module (CBM) that is the founding member of CBM family 87. Agd3 homologues are encoded in previously unidentified putative bacterial exopolysaccharide biosynthetic operons and in other fungal genomes. The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Here, the authors study an A. fumigatus enzyme that deacetylates GAG in a metal-dependent manner and constitutes a founding member of a new carbohydrate esterase family.Bio-organic Synthesi