COMMUNISM - ITS GOALS AND TECHNIQUES

Political Economy,

Design, analysis and presentation of factorial randomised controlled trials

BackgroundThe evaluation of more than one intervention in the same randomised controlled trial can be achieved using a parallel group design. However this requires increased sample size and can be inefficient, especially if there is also interest in considering combinations of the interventions. An alternative may be a factorial trial, where for two interventions participants are allocated to receive neither intervention, one or the other, or both. Factorial trials require special considerations, however, particularly at the design and analysis stages.DiscussionUsing a 2 × 2 factorial trial as an example, we present a number of issues that should be considered when planning a factorial trial. The main design issue is that of sample size. Factorial trials are most often powered to detect the main effects of interventions, since adequate power to detect plausible interactions requires greatly increased sample sizes. The main analytical issues relate to the investigation of main effects and the interaction between the interventions in appropriate regression models. Presentation of results should reflect the analytical strategy with an emphasis on the principal research questions. We also give an example of how baseline and follow-up data should be presented. Lastly, we discuss the implications of the design, analytical and presentational issues covered.SummaryDifficulties in interpreting the results of factorial trials if an influential interaction is observed is the cost of the potential for efficient, simultaneous consideration of two or more interventions. Factorial trials can in principle be designed to have adequate power to detect realistic interactions, and in any case they are the only design that allows such effects to be investigated

Dealing with homophobia in residence halls on college and university classess

Diversity is defined by Webster\u27s Dictionary as the condition of being different or having differences (Woolf, 1974, p. 215). Diversity is a major issue when discussing campus environments and can be seen as cultural, racial, economic, religious, gender, and sexual orientation. For many students, the college environment will be the first opportunity to be exposed to a wide range of diversity. Experiencing this diversity can sometimes be either enlightening or threatening for an individual, and it can be a learning opportunity

Spectral Index of the Diffuse Radio Background Measured From 100 to 200 MHz

The mean absolute brightness temperature of the diffuse radio background was measured as a function of frequency in a continuous band between 100 and 200 MHz over an effective solid angle of ~pi str at high Galactic latitude. A spectral brightness temperature index of beta = 2.5 +/- 0.1 (alpha_s = 0.5) was derived from the observations, where the error limits are 3-sigma and include estimates of the instrumental systematics. Zenith drift scans with central declinations of -26.5 degrees and spanning right ascensions 0 to 10 hours yielded little variation in the mean spectral index. The mean absolute brightness temperature at 150 MHz was found to reach a minimum of T = 237 +/- 10 K at a right ascension of 2.5 hours. Combining these measurements with those of Haslam et al. 1982 yields a spectral index of beta = 2.52 +/- 0.04 between 150 and 408 MHz.Comment: 8 pages including 7 figures and 4 tables. Accepted by A

Dynamic Singularities in Cooperative Exclusion

We investigate cooperative exclusion, in which the particle velocity can be an increasing function of the density. Within a hydrodynamic theory, an initial density upsteps and downsteps can evolve into: (a) shock waves, (b) continuous compression or rarefaction waves, or (c) a mixture of shocks and continuous waves. These unusual phenomena arise because of an inflection point in the current versus density relation. This anomaly leads to a group velocity that can either be an increasing or a decreasing function of the density on either side of these wave singularities.Comment: 4 pages, 4 figures, 2 column revtex 4-1 format; version 2: substantially rewritten and put in IOP format, mail results unchanged; version 3: minor changes, final version for publication in JSTA

Utilising Visual Attention Cues for Vehicle Detection and Tracking

Advanced Driver-Assistance Systems (ADAS) have been attracting attention from many researchers. Vision-based sensors are the closest way to emulate human driver visual behavior while driving. In this paper, we explore possible ways to use visual attention (saliency) for object detection and tracking. We investigate: 1) How a visual attention map such as a \emph{subjectness} attention or saliency map and an \emph{objectness} attention map can facilitate region proposal generation in a 2-stage object detector; 2) How a visual attention map can be used for tracking multiple objects. We propose a neural network that can simultaneously detect objects as and generate objectness and subjectness maps to save computational power. We further exploit the visual attention map during tracking using a sequential Monte Carlo probability hypothesis density (PHD) filter. The experiments are conducted on KITTI and DETRAC datasets. The use of visual attention and hierarchical features has shown a considerable improvement of $\approx$8\% in object detection which effectively increased tracking performance by $\approx$4\% on KITTI dataset.Comment: Accepted in ICPR202

The Unique-5 and -6 Motifs of ZO-1 Regulate Tight Junction Strand Localization and Scaffolding Properties

The proper cellular location and sealing of tight junctions is assumed to depend on scaffolding properties of ZO-1, a member of the MAGUK protein family. ZO-1 contains a conserved SH3-GUK module that is separated by a variable region (unique-5), which in other MAGUKs has proven regulatory functions. To identify motifs in ZO-1 critical for its putative scaffolding functions, we focused on the SH3-GUK module including unique-5 (U5) and unique-6 (U6), a motif immediately C-terminal of the GUK domain. In vitro binding studies reveal U5 is sufficient for occludin binding; U6 reduces the affinity of this binding. In cultured cells, U5 is required for targeting ZO-1 to tight junctions and removal of U6 results in ectopically displaced junction strands containing the modified ZO-1, occludin, and claudin on the lateral cell membrane. These results provide evidence that ZO-1 can control the location of tight junction transmembrane proteins and reveals complex protein binding and targeting signals within its SH3-U5-GUK-U6 region. We review these findings in the context of regulated scaffolding functions of other MAGUK protein

Overview of the MEDLI Project

The Mars Science Laboratory Entry, Descent, and Landing Instrumentation (MEDLI) Project's objectives are to measure aerothermal environments, sub-surface heatshield material response, vehicle orientation, and atmospheric density for the atmospheric entry and descent phases of the Mars Science Laboratory (MSL) entry vehicle. The flight science objectives of MEDLI directly address the largest uncertainties in the ability to design and validate a robust Mars entry system, including aerothermal, aerodynamic and atmosphere models, and thermal protection system (TPS) design. The instrumentation suite will be installed in the heatshield of the MSL entry vehicle. The acquired data will support future Mars entry and aerocapture missions by providing measured atmospheric data to validate Mars atmosphere models and clarify the design margins for future Mars missions. MEDLI thermocouple and recession sensor data will significantly improve the understanding of aeroheating and TPS performance uncertainties for future missions. MEDLI pressure data will permit more accurate trajectory reconstruction, as well as separation of aerodynamic and atmospheric uncertainties in the hypersonic and supersonic regimes. This paper provides an overview of the project including the instrumentation design, system architecture, and expected measurement response