Assessing Integrated Water Management Options for Urban Developments - Canberra case study

Urban water services in the Australian Capital Territory (ACT) are currently provided through conventional centralised systems, involving large scale water distribution, wastewater collection, water and wastewater treatment. A study was conducted to assist Environment ACT in setting broad policies for future water services in Canberra. This paper presents the outcomes of a study examining the effects of various water servicing options on water resources and the environment, for two townships in Canberra, one existing and one greenfield site. Three modelling tools were used to predict the effects of various alternative water servicing scenarios, including demand management options, rainwater tanks, greywater use, on-site detention tanks, gross pollutant traps, swales and ponds. The results show that potable water reductions are best achieved by demand management tools or a combination of greywater and rainwater use for existing suburbs, while 3rd pipe systems are preferred for greenfield sites. For this specific climatic region and end use demands, modelling predicted increased water savings from raintanks compared to greywater systems alone, with raintanks providing the additional benefit of reduced peak stormwater flows at the allotment scale. Rainwater and stormwater reuse from stormwater ponds within the catchments was found to provide the highest reduction in nutrient discharge from the case study areas. Environment ACT amended planning controls to facilitate installation of raintanks and greywater systems, and commenced a Government funded rebate scheme for raintanks as a result of this study

The reappearance of Pseudoclavellaria amerinae (Linnaeus, 1758) in Germany (Hymenoptera, Cimbicidae).

Die Keulhorn-Blattwespe Pseudoclavellaria amerinae wurde zuletzt 1976 in Deutschland gefunden und deshalb in der neuesten Roten Liste der gefährdeten Arten Deutschlands als ausgestorben eingestuft. Zwei neuere Funde in Sachsen-Anhalt werden gemeldet und im Rahmen der älteren Verbreitungsdaten diskutiert. Die meisten Nachweise von P. amerinae in Deutschland stammen von Weichholzauen entlang der großen Flüsse und deren Nebenflüsse im Tiefland. Im östlichen Deutschland sind historische und aktuelle Vorkommen am Flusssystem der Elbe konzentriert. Daten zu den Futterpflanzen der Larve werden ausgewertet. Diese sind in erster Linie glattblättrige Salix-Arten (insbesondere S. fragilis und S. alba), mit Populus-Arten als wichtige sekundäre Wirtspflanzen.Stichwörtersawfly, distribution, Europe, Elbe, host plants, floodplain forest.The sawfly Pseudoclavellaria amerinae was last found in Germany in 1976 and was treated as extinct in the latest national list of endangered species. Two recent occurrences in Saxony-Anhalt, Germany, are reported, and discussed in the context of older distributional data. Most records of P. amerinae in central Europe are from alluvial forest along lowland stretches of major rivers and their tributaries. In eastern Germany, historic and current occurrence is concentrated on the Elbe river system. Data on the larval host plants are reviewed: these are primarily smooth-leaved Salix species (particularly S. fragilis and S. alba), with Populus species as important secondary hosts.Keywordssawfly, distribution, Europe, Elbe, host plants, floodplain forest

Foreign Portfolio Investment Inflows to the United States: The Impact of Investor Risk Aversion and U.S. Stock Market Performance

This paper examines the relationship of net foreign portfolio investment inflows, namely corporate bonds and stocks, to two pull factors; investor risk aversion and the US stock market. Using a vector autoregressive model, we find that positive shocks to the stock market elicit an insignificant response to the net corporate bond inflow and a significant short term positive response to the net corporate stock inflow. The net corporate stock inflow does not respond to risk aversion, while bond inflows do exhibit a significant midterm response to an increase in risk aversion. Consistent with previous empirical findings, the results show that internal country-specific factors may influence foreign portfolio inflows

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

Background: Murine models are a crucial component of gut microbiome research. Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global understanding of the mouse microbiota landscape. Here, we investigate the variability of the healthy mouse microbiota of five common lab mouse strains using 16S rDNA pyrosequencing. Results: We find initial evidence for richness-driven, strain-independent murine enterotypes that show a striking resemblance to those in human, and which associate with calprotectin levels, a marker for intestinal inflammation. After enterotype stratification, we find that genetic, caging and inter-individual variation contribute on average 19%, 31.7% and 45.5%, respectively, to the variance in the murine gut microbiota composition. Genetic distance correlates positively to microbiota distance, so that genetically similar strains have more similar microbiota than genetically distant ones. Specific mouse strains are enriched for specific operational taxonomic units and taxonomic groups, while the 'cage effect' can occur across mouse strain boundaries and is mainly driven by Helicobacter infections. Conclusions: The detection of enterotypes suggests a common ecological cause, possibly low-grade inflammation that might drive differences among gut microbiota composition in mammals. Furthermore, the observed environmental and genetic effects have important consequences for experimental design in mouse microbiome research

Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9.

The neuronal apoptosis-inhibitory protein (NAIP) is the founding member of the mammalian family of inhibitor of apoptosis (IAP) proteins (also known as BIRC proteins) and has been shown to be antiapoptotic both in vivo and in vitro. The 160-kDa NAIP contains three distinct regions: an amino-terminal cluster of three baculoviral inhibitory repeat (BIR) domains, a central nucleotide binding oligomerization domain (NOD), and a carboxyl-terminal leucine-rich repeat (LRR) domain. The presence of the NOD and LRR domains renders NAIP unique among the IAPs and suggests that NAIP activity is regulated in a manner distinct from that of other members of the family. In this report, we examined the interaction of various regions of NAIP with caspase-9 and Smac. Recombinant NAIPs with truncations of the carboxyl-terminal LRR or NOD-LRR regions bound to caspase-9. In contrast, the full-length protein did not, suggesting some form of structural autoregulation. However, the association of the wild type full-length protein with caspase-9 was observed when interaction analysis was performed in the presence of ATP. Furthermore, mutation of the NAIP ATP binding pocket allowed full-length protein to interact with caspase-9. Thus, we conclude that NAIP binds to caspase-9 with a structural requirement for ATP and that in the absence of ATP the LRR domain negatively regulates the caspase-9-inhibiting activity of the BIR domains. Interestingly, and in contrast to the X-chromosome-linked inhibitor of apoptosis protein (XIAP), NAIP-mediated inhibition of caspase-9 was not countered by a peptide containing an amino-terminal IAP binding motif (IBM). Consistent with this observation was the failure of Smac protein to interact with the NAIP BIR domains. These results demonstrate that NAIP is distinct from the other IAPs, both in demonstrating a ligand-dependent caspase-9 interaction and in demonstrating a distinct mechanism of inhibition

Dancing Against falls iN Community-dwElling older adults (DANCE):a study protocol of a stratified, block-randomised trial

BACKGROUND: Unintentional falls among older adults are of primary importance due to their impact on quality of life. Falling accounts for 95% of hip fractures, leading to an approximately six times increased risk of death within the first 3 months. Furthermore, physical and cognitive parameters are risk factors for falls. The purpose of this study is to examine the effect of a 6-month salsa dance training intervention, compared with regular fitness circuit training and a control group. METHODS: This study will include 180 older adults: 90 healthy patients and 90 patients with osteoporosis. Participants will be allocated randomly in either of the groups, stratified according to age. Training groups will receive 2 weekly 1-hour training sessions, continuously through 6 months. Participants will be tested at baseline and 6 and 18 months post baseline. Primary outcome will be number of falls and secondary outcomes include bone mineral density, body composition, pain evaluation, weekly physical activity, single-task and dual-task gait patterns, balance, Fullerton Functional Fitness Test and assessment of the mini-BESTest. DISCUSSION: This study will investigate the effects of a specially designed dance training programme (Dancing Against falls iN Community-dwElling older adults (DANCE)) to reduce the risk of falling among older adults. The study will investigate the effect against an active and passive comparator, resulting in the possibility to state, if DANCE training should be an alternative to traditional training. TRIAL REGISTRATION NUMBER: NCT03683849

Interpreting Sentinel-1 SAR Backscatter Signals of Snowpack Surface Melt/Freeze, Warming, and Ripening, Through Field Measurements and Physically-Based SnowModel

The transition of a cold winter snowpack to one that is ripe and contributing to runoff is crucial to gauge for water resource management, but is highly variable in space and time. Snow surface melt/freeze cycles, associated with diurnal fluctuations in radiative inputs, are hallmarks of this transition. C-band synthetic aperture radar (SAR) reliably detects meltwater in the snowpack. Sentinel-1 (S1) C-band SAR offers consistent acquisition patterns that allow for diurnal investigations of melting snow. We used over 50 snow pit observations from 2020 in Grand Mesa, Colorado, USA, to track temperature and wetness in the snowpack as a function of depth and time during snowpack phases of warming, ripening, and runoff. We also ran the physically-based SnowModel, which provided a spatially and temporally continuous independent indication of snowpack conditions. Snowpack phases were identified and corroborated by comparing field measurements with SnowModel outputs. Knowledge of snowpack warming, ripening, and runoff phases was used to interpret diurnal changes in S1 backscatter values. Both field measurements and SnowModel simulations suggested that S1 SAR was not sensitive to the initial snowpack warming phase on Grand Mesa. In the ripening and runoff phases, the diurnal cycle in S1 SAR co-polarized backscatter was affected by both surface melt/freeze as well as the conditions of the snowpack underneath (ripening or ripe). The ripening phase was associated with significant increases in morning backscatter values, likely due to volume scattering from surface melt/freeze crusts, as well as significant decreases in evening backscatter values associated with snowmelt. During the runoff phase, both morning and evening backscatter decreased compared to reference values. These unique S1 diurnal signatures, and their interpretations using field measurements and SnowModel outputs, highlight the capacities and limitations of S1 SAR to understand snow surface states and bulk phases, which may offer runoff forecasting or energy balance model validation or parameterization, especially useful in remote or sparsely-gauged alpine basins

Attachment in individuals with eating disorders compared to community controls: A systematic review and meta-analysis

OBJECTIVE: Individuals with eating disorders are known to have higher rates of insecure attachment compared to community controls, but the factors underlying this finding are poorly understood. We conducted the first meta-analysis comparing attachment in eating disorder samples compared to community controls that included quality assessment, publication bias and moderation analysis. METHOD: We pre-registered our meta-analysis (CRD42019146799) and followed PRISMA guidelines. We searched PsychINFO, Embase, Medline, CINAHL, and Scopus for publications. Attachment scores were extracted, and Cohen's d calculated for each study using a random effects model. RESULTS: In total, 35 studies were included in the meta-analysis and six studies were summarized in a narrative review. Eating disorder samples showed higher rates of insecure attachment compared to community controls, with a large effect size, across measurement methods and different attachment dimensions. Blinding of assessors moderated effect sizes for attachment interview studies, but no other moderators were significant. DISCUSSION: Risk of insecure attachment is elevated in individuals with eating disorders, albeit heterogeneity is high and largely unexplained. Clinicians may need to take this into account in their work, particularly given the association between attachment insecurity and challenges to therapeutic alliance. Future studies comparing eating disorder samples with community samples should control for general psychopathology. PUBLIC SIGNIFICANCE: Attachment is a broad concept referring to a person's thoughts, feelings and behaviors in relation to close others. This systematic review and meta-analysis found that individuals with eating disorders are lower in attachment security than community controls, regardless of attachment construct or measurement approach. Attachment may be relevant in influencing eating disorder recovery, the development of therapeutic alliance, and potentially clinical outcomes, although more research is needed