Correlation between dental caries and quality of life in children

Introduction. Measuring quality of life at an individual level can provide important data on health status and the effects of healthcare services. The aim of this study was to assess the impact of caries and its treatment on quality of life (QoL) in school-aged children. Materials and methods. A cross-sectional prospective study was carried out within the Department of Pediatric Oral-Maxillo-Facial Surgery and Pedodontics Ion Lupan of the Nicolae Testemitanu SUMPh. The research group (L1) consisted of 70 children with dental caries. In the control group (L0) 70 children free of dental caries were included. For QoL assessment, the Child-Oral Impacts on Daily Performances (Child-OIDP) questionnaire was applied. The study was conducted in accordance with ethical requirements with the written consent of the children's parents. The Spearman ρ (rho) coefficient, calculated via nonparametric rank correlation test, was used to determine the correlation between tooth decay degree and its impact on children's QoL. The Child-OIDP self-administered questionnaire was used to collect data and data was analyzed using Epi-Info. Results. A total of 140 students responded, of whom 49.2% experienced at least one impact. The most affected performances were eating (22.3%), followed by smiling (18.5%) and emotional state (6.5%), and the least affected daily activities were playing (0.8%) and schoolwork (1.1%). The main causes were bleeding gums (39.3%), injury (26.8%) and sensitivity (33.7%), and adolescents reported an average of 1.5 pathologies as perceived causes of impact. Conclusion. A significant positive association of very high, high and moderate intensity was established between the indicators of dental caries and the impact of the oral health status on QoL. The high prevalence of dental caries' impact on children's QoL indicates their increased treatment needs and insufficient access to dental care. Estimating the impact of oral health status on daily performance is important for the creation of health policies that address the needs of the population

Метод паравазального эндоскопического склерозирования варикозно расширенных вен пищевода этоксисклеролом

Curs Chirurgie, facultatea Stomatologie, USMF „Nicolae Testemiţanu”, Conferinţa naţională ştiinţifico-practică în domeniul otorinolaringologiei pediatrice, 30 octombrie 2009, Chişinău, Republica MoldovaThis study examines paravasal endoscopic sclerosation with 0.5% Aethoxysklerol in 66 patients aged 30-65 with hepatic cirrhosis and portal hypertension. Endoscopic paravasal sclerosation was done to produce primary and secondary prophylaxy of haemmorages. 29 patients suffered from hepatic cirrhosis in the subdegenerative stage and 37 the decompensated stage. After ESG the esophagian varices of the 2nd and 3rd degree were found in 24 patients, and in esophagean varices of the 3rd degree in 42. Cataral esophagitis was seen in 14 patients and erosive esophagitis in 52. The survival index for 6 months was 94.3%, 1 year - 80.0%, 3 years - 65.7%, and 6 years - 48.6%. The recurrence of of haemorrhage was not seen in the first six months, and in 1 year in 3.45% of the patients, in 3 years 11.5%, and 6 years 26.1%. Patients treated with paravasal endoscopic sclerosation with 0.5% Aethoxysklerol after one year showed a higher mortality rate due to gasro-esophagean causes. No complications after the endoscopic sclerosation were observed. Endoscopic sclerosation method with 0.5% Aethoxyklerol is an effective one for haemorrage profylaxy of esophagean varices.Исследование посвящено эндоскопическому склерозированию (ЭС) расширенных вен пищевода 0,5% раствором этоксисклерола у 66 больных циррозом печени и портальной гипертензией. Этой категории больных ЭС выполнено с целью профилактики первичных и вторичных кровотечений. Возраст больных колебался от 30 до 65 лет; из них 29 страдали циррозом печени в стадии субкомпенсации и 37 – циррозом печени в стадии декомпенсации. У 24 больных, при ФЭГДС, было выявлено варикозное расширение вен пишевода II-III ст. и у 42 – варикозно расширенные вены III ст. У 14 больных был выявлен катаральный эзофагит, а у 52 больных – эррозивный эзофагит. Индекс выживаемости до 6 месяцев составлял 94,3%, до 12 месяцев – 80,0%, до 3 лет – 65,7% и до 6 лет – 48,6%. До 6 месяцев рецидивов кровотечений выявлено не было, до 12 месяцев кровотечений было у 3,45% больных, до 3 лет – у 11,5% и до 6 лет – у 26,1% больных. Анализ смертности больных после ЭС этоксисклеролом в отдалëнные сроки показал, что после первого года наблюдения среди причин смерти превалируют рецидивы кровотечений из варикозно расширенных вен пишевода, связанные со снижением эффекта ЭС. Осложнений после ЭС не было выявлено. Таким образом, ЭС с использованием 0,5% раствора этоксисклерола – это надежный метод профилактики кровотечений из варикозно расширенных вен пишевода

Медико-социальные последствия старения населения

National Center of Geriatrics and Gerontology, Republic of Moldova, Nicolae Testemitanu State Medical and Pharmaceutical University, Congresul III al Medicilor de Familie din Republica Moldova 17–18 mai, 2012, Chişinău, Republica MoldovaThis article describes the medical and social consequences of the elderly population. Essential changes are established in the demographic structure due to the changes occurring in the evolution of the main indicators of migration in the population – a phenomenon known as “demographical transition”. В этой работе описываются аспекты социальные, медицинские и экономические факторы, влияющие на здоровье возрастного населения. В содержании работы изложены последствия аспектов демографических, медицинских и социальных затрат государства от населения пожилого возраста. В этом возрасте на первом плане выделяются социально-медицинские последствия старения: заболеваемость и состояние здоровья, уровень специфической заболеваемости, причины смерти и тенденции этого феномена, доступность медицинских услуг

Ipigrix (ipidacrin) in the complex treatment of patients with idiopathic axonal polyneuropathy

Department of Neurology, Institute of Neurology and Neurosurgery, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaBackground: Peripheral neuropathy is a frequent nosologic unit, its prevalence being estimated as 2-8% of the population. Polyneuropathy treatment is especially difficult in the axonal forms cases. To study the effectiveness of the medicines acting on the pathogenetic evolution of the polyneuropathy is very important. The objectives of the study have been to assess the efficiency of ipigrix (ipidacrin) with regard to the clinical state of the patients with idiopathic axonal polyneuropathy (IAP) and to determine its influence on electromyographic indices. Material and methods: 2 groups of 30 patients with IAP have been examined in an open controlled trial. In the complex treatment of the patients of group A ipigrix (ipidacrin) has been added – 15 mg (1.5% solution – 1.0 ml) intramuscularly for 20 days. The patients of group B have received a standard treatment. Results: After the course of the treatment in the both studied groups the improvement has been recorded both in clinic and electromyographic indices. But the statistically significant changes have been observed only in group A – in the patients who have additionally received ipidacrin. These changes have been related to the significant increase of the nerve conduction velocity in motor and sensory fibers of peripheral nerves. Conclusions: ipigrix (ipidacrin) positively influences and improves the clinical outcomes and electromyographic indices in the patients with IAP. It can be successfully used in the complex treatment of axonal polyneuropathies of other determined etiologies (diabetic, alcoholic, uremic, etc.)

Главные участники в поддержании благосостояния и здоровья старшего поколения

Centrul Naţional de Geriatrie şi Gerontologie din Republica Moldova, Catedra Sănătate Publică şi Management, USMF „Nicolae Testemiţanu”, Conferinţa Ştiinţifico-Practică „Medicina modernă, actualităţi şi perspective”, consacrată aniversării de 40 de ani ai Spitalului Clinic al Ministerului Sănătăţii, 27-28 mai, 2010, Chişinău, Republica MoldovaStudies confirm that senior citizens are often closest to their families, who are sometimes the only source of support and aid; however the state is required to assume a major role in implementing national policy to maintain the welfare and health of older people. Public medical institutions, as intermediary agents of the state, aim to ensure a prosperous life for senior citizens by promoting healthy lifestyles and access to medical and social assistance. Social assistance is extremely important for senior citizens to help them maintain their active lifestyles. Social hospitals, nursing homes and rehabilitation centers for senior citizens are curative and preventive institutions where medical care is given to the elderly and other vulnerable social groups.Исследования подтверждают, что ближайшей для пожилых людей является семья, которая иногда остается единственным источником поддержки и помощи, хотя государство обязано взять на себя ведущую роль в осуществлении национальной политики в области сохранения благополучия и здоровья пожилых людей. Государственные медицинские учреждения, в качестве посреднических агентов государства, направлены на обеспечение старшего поколения благополучной жизнью путем пропаганды здорового образа жизни и доступа медицинской и социальной помощи. Социальная помощь является чрезвычайно важным фактором для пожилых людей, так как помогает их активному образу жизни. Социальные больницы, дома престарелых и реабилитационные центры для пожилых людей - это лечебные и профилактические учреждения, в которых пожилым и некоторым представителям уязвимых социальных групп предоставляется медицинская помощь

Пожилые люди - проблема общественного здравоохранения

Catedra Sănătate Publică şi Management, USMF „Nicolae Testemiţanu”, Centrul Naţional de Geriatrie şi Gerontologie din Republica Moldova, Conferinţa Ştiinţifico-Practică „Medicina modernă, actualităţi şi perspective”, consacrată aniversării de 40 de ani ai Spitalului Clinic al Ministerului Sănătăţii, 27-28 mai, 2010, Chişinău, Republica MoldovaDemographic aging is an irreversible historical process, affecting the entire population both through conditionalities and its many consequences. Currently, the age group with the highest growth rate is considered to be 80 years and older. This process is not due to “population aging”, but instead it is the result of the region’s depopulation and the reduction of the younger generations resulting from declining birth rates and maintaining high levels of infant mortality and high levels of emigration of women of reproductive age, mostly from rural areas.Старение населения – это исторический и необратимый процесс, затрагивающий всё население, как напрямую, так и через свои многочисленные последствия. В настоящее время возрастная группа с наиболее высокими темпами роста считается от 80 лет, что обусловлено не «старением населения», а депопуляцией населения, сокращением доли молодого поколения из-за снижения рождаемости и поддержания высокого уровня детской смертности в регионе, а также высокого уровня эмиграции среди женщин репродуктивного возраста, в основном из сельских районов

Особенности начала анкилозирующего спондилита с поражениями глаз

Laboratorul Ştiinţific de Gerontologie, USMF „Nicolae Testemiţanu”, Catedra Medicină Internă nr. 1, USMF “Nicolae Testemiţanu”, Conferinţa Ştiinţifico-Practică „Medicina modernă, actualităţi şi perspective”, consacrată aniversării de 40 de ani ai Spitalului Clinic al Ministerului Sănătăţii, 27-28 mai, 2010, Chişinău, Republica MoldovaThe study included 72 patients who were diagnosed with ankylosing spondylitis according to Amor criteria variation of 1984, New York. The study group (Group 1) consisted of 52 patients with ocular affection in ankyalosing spondylitis, the control group (Group 2) - 20 patients diagnosed with ankylosing spondylitis without eye lesions. Study results showed that ankylosing spondylitis begins at a young age comprising the 2nd and 3rd decades of life, with an early debut in patients with AS involving ocular alterations. The most common symptoms are morning stiffness, back pain and sacroiliac joints pain. The percentage varied in patients with or without eye symptoms.В исследование были включены 72 пациента с диагнозом анкилозирующий спондилоартрит по критериям Амор, 1984, Нью-Йорк. Основная группа состояла из 52 больных анкилозирующим спондилитом с проявлениями глазных симптомов, контрольная группа из 20 пациентов с анкилозирующим спондилоартритом без проявления глазных симптомов. Результаты исследования показали, что анкилозирующий спондилоартрит начинается в молодом возрасте в основном во 2-й и 3-й декадах жизни, с наличием глазных симптомов при более раннем начале заболевания. Самыми частыми симптомами заболевания были утренняя скованность, боли в спине и боли в крестцово-подвздошном суставе, которые были более выражены при наличии глазных симптомов

The impact of lifetime alcohol and cigarette smoking loads on amyotrophic lateral sclerosis progression: A cross-sectional study

Background—Amyotrophic lateral sclerosis (ALS) is a devastating and untreatable motor neuron disease; smoking and alcohol drinking may impact its progression rate. Objective—To ascertain the influence of smoking and alcohol consumption on ALS progression rates. Methods— Cross-sectional multicenter study, including 241 consecutive patients (145 males); mean age at onset was 59.9 ± 11.8 years. Cigarette smoking and alcohol consumption data were collected at recruitment through a validated questionnaire. Patients were categorized into three groups according to ∆FS (derived from the ALS Functional Rating Scale-Revised and disease duration from onset): slow (n = 81), intermediate (80), and fast progressors (80). Results—Current smokers accounted for 44 (18.3%) of the participants, former smokers accounted for 10 (4.1%), and non-smokers accounted for 187 (77.6%). The age of ALS onset was lower in current smokers than non-smokers, and the ∆FS was slightly, although not significantly, higher for smokers of >14 cigarettes/day. Current alcohol drinkers accounted for 147 (61.0%) of the participants, former drinkers accounted for 5 (2.1%), and non-drinkers accounted for 89 (36.9%). The log(∆FS) was weakly correlated only with the duration of alcohol consumption (p = 0.028), but not with the mean number of drinks/day or the drink-years. Conclusions: This cross-sectional multicenter study suggested a possible minor role for smoking in worsening disease progression. A possible interaction with alcohol drinking was suggested

The European antibody network's practical guide to finding and validating suitable antibodies for research

[EN]Antibodies are widely exploited as research/diagnostic tools and therapeutics. Despite providing exciting research opportunities, the multitude of available antibodies also offers a bewildering array of choice. Importantly, not all companies comply with the highest standards, and thus many reagents fail basic validation tests. The responsibility for antibodies being fit for purpose rests, surprisingly, with their user. This paper condenses the extensive experience of the European Monoclonal Antibody Network to help researchers identify antibodies specific for their target antigen. A stepwise strategy is provided for prioritising antibodies and making informed decisions regarding further essential validation requirements. Web-based antibody validation guides provide practical approaches for testing antibody activity and specificity. We aim to enable researchers with little or no prior experience of antibody characterization to understand how to determine the suitability of their antibody for its intended purpose, enabling both time and cost effective generation of high quality antibody-based data fit for publication.SIOur research has been supported by funding from Cancer Research UK (Program A10702 to A.H.B) and Bloodwise (Program 13047 to A.H.B). The research was supported by the National Institute for Health Research (NIHR) Oxford Biomedical Research Center based at Oxford University Hospitals NHS Trust and University of Oxford. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Grant No 310/6 from the Deutsche Forschungsgemeinschaft to F.K.-N. Grants from the Instituto de Salud Carlos III (PI14/00703, PN de I+D+I 2013-2016) and the CSIC (201320E109 and 201420E109) to L.K. laboratory. Grants of the Spanish Ministry of Health (Fondo de Investigaciones Sanitarias, PI10/01039), Department of Education of Castilla and León Regional Government (Grant# LE007A10–2) and Mutua Madrileña Foundation (Basic research grants 2012) to J.I.R.B. This work was supported by a grant from the Dutch government to the Netherlands Institute for Regenerative Medicine (NIRM, grant No. FES0908)

The distribution of inverted repeat sequences in the Saccharomyces cerevisiae genome

Although a variety of possible functions have been proposed for inverted repeat sequences (IRs), it is not known which of them might occur in vivo. We investigate this question by assessing the distributions and properties of IRs in the Saccharomyces cerevisiae (SC) genome. Using the IRFinder algorithm we detect 100,514 IRs having copy length greater than 6 bp and spacer length less than 77 bp. To assess statistical significance we also determine the IR distributions in two types of randomization of the S. cerevisiae genome. We find that the S. cerevisiae genome is significantly enriched in IRs relative to random. The S. cerevisiae IRs are significantly longer and contain fewer imperfections than those from the randomized genomes, suggesting that processes to lengthen and/or correct errors in IRs may be operative in vivo. The S. cerevisiae IRs are highly clustered in intergenic regions, while their occurrence in coding sequences is consistent with random. Clustering is stronger in the 3′ flanks of genes than in their 5′ flanks. However, the S. cerevisiae genome is not enriched in those IRs that would extrude cruciforms, suggesting that this is not a common event. Various explanations for these results are considered