Language, Play, and Toy Sharing in Infancy

Toy sharing between 97 Infants and their mothers was used to measure shared reference, mother and infant attention-directing strategies, and maternal and infant responsiveness. The association of toy sharing with early language and symbolic play was assessed. Infants were videotaped in a 10-minute free-play session at 11 months. Videotapes were coded for frequency of toy exchanges and level of infant symbolic play. Language was assessed at both 11 and 14 months. Maternal responsiveness to infant-initiated toy exchanges was positively related to symbolic play at 11 months. Maternal responsiveness was also related to Productive, Receptive, and Total Language scores at 14 months. Symbolic play at 11 months and language at 11 and 14 months were associated, suggesting underlying cognitive abilities associated with language and play development. Results support the notion that shared reference, maternal responsiveness, and underlying infant cognitive abilities are important components of a context where scaffolding of language and symbolic play can occur

A phenomenological exploration of the role of digital technology and media in children’s subjective well-being

This phenomenological study examined children’s subjective well-being (N = 22) in rural and urban areas of the Midwestern United States, as part of a larger multinational comparative qualitative study of children\u27s well-being. Children (8 to 12 years old) completed an extended, semi-structured qualitative interview and mapping exercise that prompted them to draw and describe the scope, aspects of, and influences on their subjective well-being. Phenomenological analyses of children’s responses were conducted to identify aspects of their contexts, including their use of digital technology and media (DTM), that were linked to children’s subjective well-being. Two main themes emerged; 1) children reported that DTM is not essential to their well-being but 2) DTM is important to their well-being. Six sub-themes emerged under the DTM is important theme. Children reported that DTM is rewarding and valuable to them, and it contributes to their life satisfaction. They also reported that DTM use enhances their connections to others, self-acceptance, autonomy, and competence and skills. Results are discussed in regards to children’s self-identified hedonic and eudaimonic aspects of their well-being, and are placed within a contextual framework of child well-being. Implications, strengths, and weaknesses of the study are discussed

It’s fun!” Using students’ voices to understand the impact of school digital technology integration on their well-being

The purpose of this phenomenological study was to better understand children’s perception of their school-based educational technology use and its role in their well-being. Children (N = 23) from the Midwestern U.S. completed an interview and mapping exercise focused on the contexts and factors that impact their well-being, including schools and teachers. Phenomenological analyses of interview transcripts focused on children’s perceptions of 1) school educational technology use, and 2) the impact of school educational technology use on their well-being. Children described a variety of school educational technology experiences, which they perceived as having both positive and negative effects on their well-being. Findings are discussed in the context of the historical challenges to school educational technology integration and children’s well-being

School climate, emotions, and relationships : children’s experiences of well-being in the Midwestern U.S.

The purpose of this phenomenological study was to explore children’s perceptions of school relationships, and the ways in which those relationships supported or undermined children’s emotional well-being (EWB). This sub-study of a multinational comparative investigation of children’s well-being followed a semi-structured qualitative interview protocol. Rural and urban children (age 8 to 13, N = 23) from the Midwestern U.S. completed the interview and mapping exercise used to explore aspects of and influences on their subjective well-being (including school). Phenomenological analyses of interview transcripts focused on 1) the essence of children’s EWB (including emotional valence and arousal) within the context of school relationships and 2) children’s perception of the impact of school relationships on their EWB. A seasonal metaphor captured the essence of children’s experiences of EWB, which naturally clustered into four themes based on emotional intensity and valance: spring, summer, fall, and winter. Children’s emotional experiences with teachers and peers were similarly represented in the themes, with the exception of winter emotions, which diverged. Children expressed complex, multilayered emotions within the school setting that were connected to the quality of school relationships. Findings are discussed in the context of improving school relationships and climate to support children’s EWB.peer-reviewe

Health communication messaging about HPV vaccine in Papua New Guinea.

Objective: The type of health education messages that communities and individuals seek to have communicated about the human papillomavirus (HPV) vaccine is important if vaccine programmes are to succeed, especially in settings such as Papua New Guinea (PNG), which have a high burden of cervical cancer, low health literacy and negative experiences of earlier vaccination programmes. This study sought to identify the health education messages that are viewed as most appropriate in such a context. Methodology: A qualitative study using gender-specific focus group discussions (N = 21) and semi-structured interviews (N = 82) was undertaken in three sites in PNG. Sites included both rural and urban locations in Milne Bay, Eastern Highlands and Western Highlands Provinces. Results: Two divergent discourses emerged. One group of participants, largely young people, felt communication messages should stress that HPV is a preventable sexually transmitted infection, which can cause cervical cancer. The other group, mainly members of the older population, believed that messaging should focus on the vaccine as a prevention strategy for cervical cancer. A small minority wanted both aspects of the vaccine discussed. Conclusion: Sensitivity needs to be taken when engaging with communities which have negative experiences of earlier infant immunisation programmes. Ensuring that the health communication needs and priorities of different sections of the populations are taken into account is key to the successful introduction and roll-out of HPV vaccination in this setting

HPV vaccination in Papua New Guinea to prevent cervical cancer in women: Gender, sexual morality, outsiders and the de-feminization of the HPV vaccine

First study of HPV vaccine acceptability in Papua New Guinea and the Pacific. Evidence of strong support for the vaccination of both girls and boys against HPV in Papua New Guinea. Local beliefs and concerns about HPV immunisation may impact acceptability in Papua New Guinea. Suspicion of Western medicine and health care workers reported in rural areas

Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.

Copy number (CN) variation (CNV) has been shown to be common in regions of the genome coding for immune-related genes, and thus impacts upon polygenic autoimmunity. Low CN of FCGR3B has recently been associated with systemic lupus erythematosus (SLE). FcgammaRIIIb is a glycosylphosphatidylinositol-linked, low affinity receptor for IgG found predominantly on human neutrophils. We present novel data demonstrating that both in a family with FcgammaRIIIb-deficiency and in the normal population, FCGR3B CNV correlates with protein expression, with neutrophil uptake of and adherence to immune complexes, and with soluble serum FcgammaRIIIb. Reduced FcgammaRIIIb expression is thus likely to contribute to the impaired clearance of immune complexes, which is a feature of SLE, explaining the association between low FCGR3B CNV and SLE that we have confirmed in a Caucasian population. In contrast, antineutrophil cytoplasmic antibody-associated systemic vasculitis (AASV), a disease not associated with immune complex deposition, is associated with high FCGR3B CN. Thus, we define a role for FCGR3B CNV in immune complex clearance, a function that may explain why low FCGR3B CNV is associated with SLE, but not AASV. This is the first report of an association between disease-related gene CNV and variation in protein expression and function that may contribute to autoimmune disease susceptibility

SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers

BACKGROUND: SnoN is an important regulator of the transforming growth factor beta (TGFβ) signalling pathway and has been shown to exhibit both tumour promotion and suppression activity. METHODS: To further explore the role of this complex molecule in colorectal tumorigenesis, we examined 52 paired normal and tumour colorectal specimens stratified by level of microsatellite instability; 18 with high-level microsatellite instability (MSI-H) and 34 microsatellite stable (MSS). SnoN transcript expression was quantitated by real-time PCR and analysed with respect to clinical indicators of prognosis. RESULTS: Within the MSI-H subgroup, SnoN was commonly either up-regulated (6/18, 33%) or down-regulated (7/18, 39%). A significantly different distribution of SnoN expression was observed in MSS cancers compared with MSI-H (P ≤ 0.001). Whilst 17/34 (50%) of MSS tumours demonstrated up-regulation, none showed down-regulated expression. Within the MSI-H subgroup, up-regulation was significantly correlated with lack of repeat tract mutation in the TGFβRII gene (P ≤ 0.025), suggesting that SnoN is more frequently up-regulated in the presence of functional TGFβ signalling. CONCLUSION: Together these data support the notion that SnoN has both oncogenic and tumour suppressive properties depending on other genetic changes within the tumour, and that the MSI-H pathway of colorectal tumorigenesis presents an excellent model for the study of these opposing functions