An Empirical Investigation of a 21st Century Career Development Program for Business Majors

When a small, Midwestern business school launched a required, four-year career development curriculum, robust practicum courses, and a dynamic, co-curricular program, it proved itself to be in the vanguard of career development practices. Due to the extensive experiential learning this program provides, greater numbers of business and accounting majors are graduating with raised employment aspirations and the knowledge, skills, and confidence to begin their professional lives. Using quantitative measures, the results suggest the positive impact of these career development activities on students’ certainty about career direction, assessment of the quality of their resumes and LinkedIn profiles, and confidence in interviewing

A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential

Under different pathological conditions, aberrant induction of neuronal nitric oxide synthase (nNOS) generates overproduction of NO that can cause irreversible cell damage. The aim of this study was to develop an amidoxime prodrug of a potent nNOS inhibitor, the benzhydryl acetamidine. We synthesized the benzhydryl acetamidoxime, which was evaluated in vitro to ascertain the potential NOS inhibitory activity, as well as conducting bioconversion into the parent acetamidine. The prodrug was also profiled for in vitro physicochemical properties, by determining the lipophilicity, passive permeation through the human gastrointestinal tract and across the blood-brain barrier by PAMPA, and chemical, enzymatic, and plasma stability. The obtained data demonstrate that the amidoxime prodrug shows an improved pharmacokinetic profile with respect to the acetamidine nNOS inhibitor, thus suggesting that it could be a promising lead compound to treat all those pathological conditions in which nNOS activity is dysregulated

High Quality Care and Ethical Pay-for-Performance: A Society of General Internal Medicine Policy Analysis

BACKGROUND: Pay-for-performance is proliferating, yet its impact on key stakeholders remains uncertain. OBJECTIVE: The Society of General Internal Medicine systematically evaluated ethical issues raised by performance-based physician compensation. RESULTS: We conclude that current arrangements are based on fundamentally acceptable ethical principles, but are guided by an incomplete understanding of health-care quality. Furthermore, their implementation without evidence of safety and efficacy is ethically precarious because of potential risks to stakeholders, especially vulnerable patients. CONCLUSION: We propose four major strategies to transition from risky pay-for-performance systems to ethical performance-based physician compensation and high quality care. These include implementing safeguards within current pay-for-performance systems, reaching consensus regarding the obligations of key stakeholders in improving health-care quality, developing valid and comprehensive measures of health-care quality, and utilizing a cautious evaluative approach in creating the next generation of compensation systems that reward genuine quality

Gender Effects as Macro-Level Effects: Germany and the United States 1991–1997

Abstract My research examines within-nation differences as well as cross-national differences in socially stratified outcomes, specifically the distribution of household incomes. I build on the considerable empirical evidence suggesting that group memberships are important factors in shaping one's life course and in determining the level of social inequality. I examine seven years of longitudinal data from Germany and the United States, 1991–1997 to demonstrate that gender is situated within other salient social categories such as race and marital status. These qualitative distinctions form status-based groups that organize the social hierarchy in which individual action is both enabled and constrained

Constructing social research : the unity and diversity of method

xii, 234 hlm.; ill.; 23 cm