Randomised controlled trial of a theoretically grounded tailored intervention to diffuse evidence-based public health practice [ISRCTN23257060]

BACKGROUND: Previous studies have shown that Norwegian public health physicians do not systematically and explicitly use scientific evidence in their practice. They work in an environment that does not encourage the integration of this information in decision-making. In this study we investigate whether a theoretically grounded tailored intervention to diffuse evidence-based public health practice increases the physicians' use of research information. METHODS: 148 self-selected public health physicians were randomised to an intervention group (n = 73) and a control group (n = 75). The intervention group received a multifaceted intervention while the control group received a letter declaring that they had access to library services. Baseline assessments before the intervention and post-testing immediately at the end of a 1.5-year intervention period were conducted. The intervention was theoretically based and consisted of a workshop in evidence-based public health, a newsletter, access to a specially designed information service, to relevant databases, and to an electronic discussion list. The main outcome measure was behaviour as measured by the use of research in different documents. RESULTS: The intervention did not demonstrate any evidence of effects on the objective behaviour outcomes. We found, however, a statistical significant difference between the two groups for both knowledge scores: Mean difference of 0.4 (95% CI: 0.2–0.6) in the score for knowledge about EBM-resources and mean difference of 0.2 (95% CI: 0.0–0.3) in the score for conceptual knowledge of importance for critical appraisal. There were no statistical significant differences in attitude-, self-efficacy-, decision-to-adopt- or job-satisfaction scales. There were no significant differences in Cochrane library searching after controlling for baseline values and characteristics. CONCLUSION: Though demonstrating effect on knowledge the study failed to provide support for the hypothesis that a theory-based multifaceted intervention targeted at identified barriers will change professional behaviour

Diagnostic accuracy of three types of fall risk methods for predicting falls in nursing homes

AIMS: To determine the diagnostic accuracy of three different methods for identifying individuals at high risk of falling. The St- Thomas Risk Assessment tool (STRATIFY- modified for nursing homes), staff judgment of fall risk, and previous falls remembered by the staff were evaluated. We also examined whether a combination of two of the methods would increase accuracy. MATERIALS AND METHODS: A prospective observational cohort study was carried out for 18 months. One thousand one hundred and forty-eight participants were included and assessed for fall risk. Falls among these residents were recorded from the date of inclusion to the date of death, transfer, or end of observation time. Diagnostic accuracy was evaluated in terms of sensitivity, specificity, predictive values and likelihood ratios, as well as Kaplan-Meier estimates and the Cox proportional hazard model, with time to the first fall as the dependent variable. Sensitivity, specificity, predictive value and likelihood ratios were calculated for falls within 30, 90 and 180 days of assessment for fall risk. RESULTS: Five hundred and seventy (49.6%) of the 1148 residents had one or more falls during the observation period. One thousand one hundred had more than 30 days of observation, 987 more than 90 days, and 867 more than 180 days. For falls within 30 days of assessment for fall risk, sensitivity varied from 65% to 72%, specificity from 69% to 75%, positive predictive value from 31% to 35% and negative predictive value from 91% to 92%. Sensitivity and negative predictive value decreased for falls within 90 days and decreased further for falls within 180 days, whereas specificity and positive predictive value increased for all three assessment methods. Staff judgment of fall risk was the single method having the highest sensitivity but the lowest specificity. A combination of either two of them increased sensitivity to more than 80%, but decreased specificity. The positive Likelihood ratio varied from 2.24 to 2.70 and the negative Likelihood ratio from 0.41 to 0.49 for falls within 30 days. The relative risk of sustaining a fall was 2.4, 2.9 and 3.0 times higher for those assessed to be at high risk of falls compared with those assessed to be at low risk, according to STRATIFY, staff judgment of fall risk and previous falls remembered by the staff, respectively. CONCLUSIONS: The diagnostic accuracy of the three methods did not differ markedly. However, staff judgment had the highest sensitivity and the lowest specificity after 30, 90 and 180 days. A combination of either two of the methods showed the highest sensitivity but the lowest specificity

Diagnostic accuracy of three types of fall risk methods for predicting falls in nursing homes

AIMS: To determine the diagnostic accuracy of three different methods for identifying individuals at high risk of falling. The St- Thomas Risk Assessment tool (STRATIFY- modified for nursing homes), staff judgment of fall risk, and previous falls remembered by the staff were evaluated. We also examined whether a combination of two of the methods would increase accuracy. MATERIALS AND METHODS: A prospective observational cohort study was carried out for 18 months. One thousand one hundred and forty-eight participants were included and assessed for fall risk. Falls among these residents were recorded from the date of inclusion to the date of death, transfer, or end of observation time. Diagnostic accuracy was evaluated in terms of sensitivity, specificity, predictive values and likelihood ratios, as well as Kaplan-Meier estimates and the Cox proportional hazard model, with time to the first fall as the dependent variable. Sensitivity, specificity, predictive value and likelihood ratios were calculated for falls within 30, 90 and 180 days of assessment for fall risk. RESULTS: Five hundred and seventy (49.6%) of the 1148 residents had one or more falls during the observation period. One thousand one hundred had more than 30 days of observation, 987 more than 90 days, and 867 more than 180 days. For falls within 30 days of assessment for fall risk, sensitivity varied from 65% to 72%, specificity from 69% to 75%, positive predictive value from 31% to 35% and negative predictive value from 91% to 92%. Sensitivity and negative predictive value decreased for falls within 90 days and decreased further for falls within 180 days, whereas specificity and positive predictive value increased for all three assessment methods. Staff judgment of fall risk was the single method having the highest sensitivity but the lowest specificity. A combination of either two of them increased sensitivity to more than 80%, but decreased specificity. The positive Likelihood ratio varied from 2.24 to 2.70 and the negative Likelihood ratio from 0.41 to 0.49 for falls within 30 days. The relative risk of sustaining a fall was 2.4, 2.9 and 3.0 times higher for those assessed to be at high risk of falls compared with those assessed to be at low risk, according to STRATIFY, staff judgment of fall risk and previous falls remembered by the staff, respectively. CONCLUSIONS: The diagnostic accuracy of the three methods did not differ markedly. However, staff judgment had the highest sensitivity and the lowest specificity after 30, 90 and 180 days. A combination of either two of the methods showed the highest sensitivity but the lowest specificity

Duration of labor and the risk of severe postpartum hemorrhage: A case-control study

Objective Our main objective was to investigate the association between duration of active labor and severe postpartum hemorrhage. We examined the effect of the total duration of active labor, the effect of each stage of active labor, and the gradient effect of duration of labor on severe postpartum hemorrhage. Methods A case-control study was generated from a source population of all women admitted for delivery at Oslo University Hospital and Drammen Hospital in Buskerud municipality during the time period January 1, 2008 to December 31, 2011. The study population included all cases of severe postpartum hemorrhage (n = 859) and a random sample of controls (n = 1755). Severe postpartum hemorrhage was defined as postpartum blood loss >= 1500 mL or need for blood transfusion. Prolonged labor was defined as duration of active labor >12 hours according to the definition of the World Health Organization. We used logistic multi-variable regression in the analysis. Results We observed a significantly longer mean duration of labor in women who experienced severe postpartum hemorrhage compared to controls (5.4 versus 3.8 hours, p12 hours (adjusted odds ratio = 2.44, 95% confidence interval: 1.69-3.53, p 12 hours) was associated with severe postpartum hemorrhage. Increased vigilance seems required when the labor is prolonged to reduce the risk of severe postpartum hemorrhage

Elective cesarean section or not? Maternal age and risk of adverse outcomes at term: a population-based registry study of low-risk primiparous women

Background Maternal age at delivery and cesarean section rates are increasing. In older women, the decision on delivery mode may be influenced by a reported increased risk of surgical interventions during labor and complications with increasing maternal age. We examined the association between maternal age and adverse outcomes in low-risk primiparous women, and the risk of adverse outcomes by delivery modes, both planned and performed (elective and emergency cesarean section, operative vaginal delivery, and unassisted vaginal delivery) in women aged ≥ 35 years. Methods A population-based registry study was conducted using data from the Medical Birth Registry of Norway and Statistics Norway including 169,583 low-risk primiparas with singleton, cephalic labors at ≥ 37 weeks during 1999 − 2009. Outcomes studied were obstetric blood loss, maternal transfer to intensive care units, 5-min Apgar score, and neonatal complications. We adjusted for potential confounders using relative risk models and multinomial logistic regression. Results Most adverse outcomes increased with increasing maternal age. However, the increase in absolute risks was low, except for moderate obstetric blood loss and transfer to the neonatal intensive care unit (NICU). Operative deliveries increased with increasing maternal age and in women aged ≥ 35 years, the risk of maternal complications in operative delivery increased. Neonatal adverse outcomes increased mainly in emergency operative deliveries. Moderate blood loss was three times more likely in elective and emergency cesarean section than in unassisted vaginal delivery, and twice as likely in operative vaginal delivery. Low Apgar score and neonatal complications occurred two to three times more often in emergency operative deliveries than in unassisted vaginal delivery. However, comparing outcomes after elective cesarean section and planned vaginal delivery, only moderate blood loss (higher in elective cesarean section), neonatal transfer to NICU and neonatal infections (both higher in planned vaginal delivery) differed significantly. Conclusions Most studied adverse outcomes increased with increasing maternal age, as did operative delivery. Although emergency operative procedures were associated with an increased risk of adverse outcomes, the absolute risk difference in complications between the modes of delivery was low for the majority of outcomes studied