"Things Are Different Now But": Older LGBT Adults' Experiences and Unmet Needs in Health Care.

Background: Approximately 2.7 million U.S. older adults self-identify as lesbian, gay, bisexual, and transgender (LGBT). Many felt unsafe revealing their sexual orientation until relatively recently, and may still not be "out" to medical providers. The aim of this study was to increase understanding of the experiences and needs of older LGBT adults when accessing care. Method: Individual semistructured interviews were conducted with 10 individuals aged 65 years or older from a local LGBT community. Interviews were audio taped and transcribed verbatim. Transcripts were analyzed via thematic analysis. Results: Major themes were "Outness," "Things are Different Now," and "Additional Resources." These describe participant comfort with being "out"; how treatment they received changed over time, and needed services or other options from the community. Conclusion: While many older LGBT adults are accustomed to navigating social mores to avoid negative experiences, nurses as well as other health care providers must be prepared to create trusting relationships with these individuals to provide truly comprehensive care

Life Amidst Rubble: Migrant Mental Health and the Management of Subjectivity in Urban China

While previous studies have documented the trials of rural-to-urban migration in post-reform China, little is known of the consequences of urban demolition and attendant uncertainty on migrant mental health. Exploring the affective and subjective dimensions of life lived amidst rubble in a migrant neighborhood on the outskirts of Shanghai, this essay describes and analyzes small-scale practices of endurance through dynamics of time, place, and sociality. We understand these modes of dwelling in a ruined environment as key to what we refer to as the management of subjectivity, producing moments of being that potentially enable to feel and act otherwise. Considering the management of subjectivity in its own rights rather than as mere echoes of postsocialist governmentalities, we sustain a dialogue with recent writing on the production of happy and self-reliant marginalized subjects through the Chinese authorities' turn to “therapeutic governance.”ESRC Newton Gran

PENGARUH KEGIATAN KEAGAMAAN TERHADAP KEPRIBADIAN MUHSIN SISWA KELAS VIII DI MTS MISYKAT AL-ANWAR KWARON JOMBANG

Religious activities on personality are very continuous, we know that by doing religious activities will form a good personality. As is the case with prayer, that there is a significant correlation between the vertical dimension and the horizontal dimension, which means that the better the individual's spirituality level towards God, the better his social behaviour. Such is the case at Madrasah Tsanawiyah Terpadu Misykat Al-Anwar Kwaron Jombang which has implemented religious activities. The application of religious activities is due to the decreasing number of student ethics among adolescents. This has become a researcher's interest to find out more about the influence of religious activities on student personality. This study aims to determine how much influence the implementation of religious activities has on student personality. This study uses a quantitative approach, the study design uses ex post facto and correlational types. Data collection techniques consisted of documentation and questionnaires. In this study, the data analysis used the product-moment, Cronbach's alpha and Spearman rank with SPSS 16. Based on the results of the Spearman rank test, the obtained sig was 0.000, which means that Ha is accepted and H0 is rejected, which means that there is a positive and significant influence between the variables. religious activities and student personality. In the column the correlation coefficient between religious activities on student personality is 0.681, which is between the values of 0.600 - 0.799, this means that it has a strong influence

Upconversion nanoparticles for sensing pH.

Upconversion nanoparticles (UCNPs) can provide a vehicle for chemical imaging by coupling chemically sensitive dyes and quenchers. The mechanism for coupling of two anthraquinone dyes, Calcium Red and Alizarin Red S, was investigated as a function of pH. The green emission band of the UCNPs was quenched by a pH-dependent inner filter effect (IFE) while the red emission band remained unchanged and acted as the reference signal for ratiometric pH measurements. Contrary to previous expectation, there was little evidence for a resonance energy transfer (RET) mechanism even when the anthraquinones were attached onto the UCNPs through electrostatic attraction. Since the UCNPs are point emitters, only emitters close to the surface of the UCNP are within the expected Förster distance and UC-RET is <10%. The theoretical and experimental analysis of the interaction between UCNPs and pH-sensitive quenchers will allow the design of UCNP pH sensors for determination of pH via IFE.This work was supported by the EPSRC Cambridge NanoDTC, EP/L015978/

Tender, Love and care

Sammendrag Bakgrunn Trykksår defineres som sårdannelse og iskemisk nekrose i hud og eventuell underliggende vev som har vært utsatt for et så langvarig trykk at blodsirkulasjonen har blitt komprimert. Det er en tilstand som er vanlig å møte i det norske helsevesenet idag og som kan medføre store plager for de pasienter som rammes. Da vi ut fra egen erfaring vet at det rettes lite fokus på trykksårsproblematikken på sykehjem idag, ønsker vi med denne oppgaven å kvalitetsforbedre det forebyggende arbeidet i forhold til trykksår. Som utgangspunkt har vi valgt en fiktiv sykehjemsavdeling som vårt mikrosystem, da det viste seg vanskelig å fokusere på et spesifikt sykehjem i området. Vi mener dette er et område med stor potensiale til kvalitetsforbedring og at dette er et tema som bør belyses da trykksår kan lede til konsekvensener for både den enkelte pasienten og for samfunnet. Kunnskapsgrunnlag Vårt kunnskapsgrunnlag er basert på søk i databasene Clinical Evidence, Up To Date, Cochrane Library og PubMed. Vi har dessuten vært i kontakt med et flertall sykehjem i Oslo-området via telefon, samt fått lov å besøke et sykehjem i Oslo for å få ytterligere informasjon om temaet. Vi har i vårt arbeide vært interessert i å finne kunnskap om trykksår og forebygging, samt kunnskap om effekten av bruk av sjekklister i praksis. Begrunnet tiltak og metode Vi har fokusert på identifisering av risikopasienter og deretter et forebyggende tiltak hos de utsatte pasientene. Når det gjelder forebygging av trykksår er det mange tiltak som har vist seg effektive. For å begrense vårt tiltak har vi valgt ut reposisjonering av pasienter og kontroll av huden, som er to enkle og gjennomførbare tiltak for å forebygge trykksår. Vi ønsker å implementere bruk av Norton-scale for risikoidentifisering samt registrering av reposisjonering og kontroll av huden med hjelp av en sjekkliste hos de pasienter med økt risiko for trykksår. Organisering Ved implementering av vårt forbedringsarbeid må ledelsen ved sykehjemsavdeligen involveres. Vi vil arrangere innføringsmøter for de ulike faggruppene. Avdelingssykepleie

Radionuclide Labeling and Evaluation of Candidate Radioligands for PET Imaging of Histone Deacetylase in the Brain

Histone deacetylases (HDACs) regulate gene expression by inducing conformational changes in chromatin. Ever since the discovery of a naturally occurring HDAC inhibitor, trichostatin A (TSA) stimulated the recent development of suberoylanilide (SAHA, Zolinza®), HDAC has become an important molecular target for drug development. This has created the need to develop specific in vivo radioligands to study epigenetic regulation and HDAC engagement for drug development for diseases including cancer and psychiatric disorders. 6-([18F]Fluoroacetamido)-1-hexanoicanilide ([18F]FAHA) was recently developed as a HDAC substrate and shows moderate blood–brain barrier (BBB) permeability and specific signal (by metabolic trapping/or deacetylation) but rapid metabolism. Here, we report the radiosynthesis of two carbon-11 labeled candidate radiotracers (substrate- and inhibitor-based radioligand) for HDAC and their evaluation in non-human primate brain. PET studies showed very low brain uptake and rapid metabolism of both labeled compounds but revealed a surprising enhancement of brain penetration by F for H substitution when comparing one of these to [18F]FAHA. Further structural refinement is needed for the development of brain-penetrant, metabolically stable HDAC radiotracers and to understand the role of fluorine substitution on brain penetration.Chemistry and Chemical Biolog

High quality and quantity Genome-wide germline genotypes from FFPE normal tissue

<p>Abstract</p> <p>Background</p> <p>Although collections of formalin fixed paraffin embedded (FFPE) samples exist, sometimes representing decades of stored samples, they have not typically been utilized to their full potential. Normal tissue from such samples would be extremely valuable for generation of genotype data for individuals who cannot otherwise provide a DNA sample.</p> <p>Findings</p> <p>We extracted DNA from normal tissue identified in FFPE tissue blocks from prostate surgery and obtained complete genome wide genotype data for over 500,000 SNP markers for these samples, and for DNA extracted from whole blood for 2 of the cases, for comparison.</p> <p>Four of the five FFPE samples of varying age and amount of tissue had identifiable normal tissue. We obtained good quality genotype data for between 89 and 99% of all SNP markers for the 4 samples from FFPE. Concordance rates of over 99% were observed for the 2 samples with DNA from both FFPE and from whole blood.</p> <p>Conclusions</p> <p>DNA extracted from normal FFPE tissue provides excellent quality and quantity genome-wide genotyping data representing germline DNA, sufficient for both linkage and association analyses. This allows genetic analysis of informative individuals who are no longer available for sampling in genetic studies.</p

Vertebral Bomb Radiocarbon Suggests Extreme Longevity in White Sharks

Conservation and management efforts for white sharks (Carcharodon carcharias) remain hampered by a lack of basic demographic information including age and growth rates. Sharks are typically aged by counting growth bands sequentially deposited in their vertebrae, but the assumption of annual deposition of these band pairs requires testing. We compared radiocarbon (Δ14C) values in vertebrae from four female and four male white sharks from the northwestern Atlantic Ocean (NWA) with reference chronologies documenting the marine uptake of 14C produced by atmospheric testing of thermonuclear devices to generate the first radiocarbon age estimates for adult white sharks. Age estimates were up to 40 years old for the largest female (fork length [FL]: 526 cm) and 73 years old for the largest male (FL: 493 cm). Our results dramatically extend the maximum age and longevity of white sharks compared to earlier studies, hint at possible sexual dimorphism in growth rates, and raise concerns that white shark populations are considerably more sensitive to human-induced mortality than previously thought

Early Respiratory Management of Respiratory Distress Syndrome in Very Preterm Infants and Bronchopulmonary Dysplasia: A Case-Control Study

BACKGROUND: In the period immediately after birth, preterm infants are highly susceptible to lung injury. Early nasal continuous positive airway pressure (ENCPAP) is an attempt to avoid intubation and may minimize lung injury. In contrast, ENCPAP can fail, and at that time surfactant rescue can be less effective. OBJECTIVE: To compare the pulmonary clinical course and outcome of very preterm infants (gestational age 25–32 weeks) with respiratory distress syndrome (RDS) who started with ENCPAP and failed (ECF group), with a control group of infants matched for gestational age, who were directly intubated in the delivery room (DRI group). Primary outcome consisted of death during admission or bronchopulmonary dysplasia (BPD). RESULTS: 25 infants were included in the ECF group and 50 control infants matched for gestational age were included in the DRI group. Mean gestational age and birth weight in the ECF group were 29.7 weeks and 1,393 g and in the DRI group 29.1 weeks and 1,261 g (p = NS). The incidence of BPD was significantly lower in the ECF group than in the DRI group (4% vs. 35%; P<0.004; OR 12.6 (95% CI 1.6–101)). Neonatal mortality was similar in both groups (4%). The incidence of neonatal morbidities such as severe cerebral injury, patent ductus arteriosus, necrotizing enterocolitis and retinopathy of prematurity, was not significantly different between the two groups. CONCLUSION: A trial of ENCPAP at birth may reduce the incidence of BPD and does not seem to be detrimental in very preterm infants. Randomized controlled trials are needed to test whether early respiratory management of preterm infants with RDS plays an important role in the development of BPD

A qualitative investigation of breast cancer survivors’ experiences with breastfeeding

This is an exploratory, qualitative investigation of breast cancer survivors’ experiences with breastfeeding. Previous studies have focused on the physiology of lactation after surgery and treatment, but have not explored factors influencing breastfeeding decisions and behavior. We used purposeful sampling to identify 11 breast cancer survivors who had a child after their diagnosis and treatment. Participants were recruited from among those in the Women’s Healthy Eating and Living (WHEL) study and a Young Survival Coalition (YSC) affiliate. We conducted semi-structured, open-ended telephone interviews lasting 45–75 min. We used social cognitive theory (SCT) to structure questions regarding influences on breastfeeding behavior. We transcribed interviews and used cross-case, inductive analysis to identify themes. Ten of 11 participants initiated breastfeeding. The following main themes emerged: 1) Cautiously hopeful, 2) Exhausting to rely on one breast, 3) Motivated despite challenges, 4) Support and lack of support, and 5) Encouraging to others. Study participants were highly motivated to breastfeed but faced considerable challenges. Participants described problems that are not unique to women with breast cancer, but experienced these to a much greater degree because they relied mostly or entirely on one lactating breast. This study revealed a need for improved access to information and support and greater sensitivity to the obstacles faced by breast cancer survivors. Results of this qualitative analysis indicate that interventions to support the efforts of breast cancer survivors who are interested in breastfeeding are warranted. Additional research would aid in the development of such interventions