1,386 research outputs found
Magnetoresistance of UPt3
We have performed measurements of the temperature dependence of the
magnetoresistance up to 9 T in bulk single crystals of UPt3 with the magnetic
field along the b axis, the easy magnetization axis. We have confirmed previous
results for transverse magnetoresistance with the current along the c axis, and
report measurements of the longitudinal magnetoresistance with the current
along the b axis. The presence of a linear term in both cases indicates broken
orientational symmetry associated with magnetic order. With the current along
the c axis the linear term appears near 5 K, increasing rapidly with decreasing
temperature. For current along the b axis the linear contribution is negative.Comment: 6 pages, 3 figures, submitted to Quantum Fluids and Solids Conference
(QFS 2006
Positive Surgical Margins in the 10 Most Common Solid Cancers.
A positive surgical margin (PSM) following cancer resection oftentimes necessitates adjuvant treatments and carries significant financial and prognostic implications. We sought to compare PSM rates for the ten most common solid cancers in the United States, and to assess trends over time. Over 10 million patients were identified in the National Cancer Data Base from 1998-2012, and 6.5 million had surgical margin data. PSM rates were compared between two time periods, 1998-2002 and 2008-2012. PSM was positively correlated with tumor category and grade. Ovarian and prostate cancers had the highest PSM prevalence in women and men, respectively. The highest PSM rates for cancers affecting both genders were seen for oral cavity tumors. PSM rates for breast cancer and lung and bronchus cancer in both men and women declined over the study period. PSM increases were seen for bladder, colon and rectum, and kidney and renal pelvis cancers. This large-scale analysis appraises the magnitude of PSM in the United States in order to focus future efforts on improving oncologic surgical care with the goal of optimizing value and improving patient outcomes
Have we seen the geneticisation of society? Expectations and evidence
Abby Lippman’s geneticization thesis, of the early 1990s, argued and anticipated that with
the rise of genetics, increasing areas of social and health related activities would come to be
understood and defined in genetic terms leading to major changes in society, medicine and
health care. We review the considerable literature on geneticization and consider how the
concept stands both theoretically and empirically across scientific, clinical, popular and lay
discourse and practice. Social science scholarship indicates that relatively little of the original
claim of the geneticization thesis has been realised, highlighting the development of more
complex and dynamic accounts of disease in scientific discourse and the complexity of
relationships between bioscientific, clinical and lay understandings. This scholarship
represents a shift in social science understandings of the processes of sociotechnical change,
which have moved from rather simplistic linear models to an appreciation of disease
categories as multiply understood. Despite these shifts, we argue that a genetic imaginary
persists, which plays a performative role in driving investments in new gene-based
developments. Understanding the enduring power of this genetic imaginary and its
consequences remains a key task for the social sciences, one which treats ongoing genetic
expectations and predictions in a sceptical yet open way
The non-coding landscape of head and neck squamous cell carcinoma.
Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease marked by frequent recurrence and metastasis and stagnant survival rates. To enhance molecular knowledge of HNSCC and define a non-coding RNA (ncRNA) landscape of the disease, we profiled the transcriptome-wide dysregulation of long non-coding RNA (lncRNA), microRNA (miRNA), and PIWI-interacting RNA (piRNA) using RNA-sequencing data from 422 HNSCC patients in The Cancer Genome Atlas (TCGA). 307 non-coding transcripts differentially expressed in HNSCC were significantly correlated with patient survival, and associated with mutations in TP53, CDKN2A, CASP8, PRDM9, and FBXW7 and copy number variations in chromosomes 3, 5, 7, and 18. We also observed widespread ncRNA correlation to concurrent TP53 and chromosome 3p loss, a compelling predictor of poor prognosis in HNSCCs. Three selected ncRNAs were additionally associated with tumor stage, HPV status, and other clinical characteristics, and modulation of their expression in vitro reveals differential regulation of genes involved in epithelial-mesenchymal transition and apoptotic response. This comprehensive characterization of the HNSCC non-coding transcriptome introduces new layers of understanding for the disease, and nominates a novel panel of transcripts with potential utility as prognostic markers or therapeutic targets
Treatment as Prevention-Provider Knowledge and Counseling Lag Behind Global Campaigns
INTRODUCTION In 2011, the landmark HIV Prevention Trials Network (HPTN) 052 trial found that early initiation of antiretroviral treatment (ART) in persons living with HIV (PLHIV) reduced viral transmission to uninfected partners by 96%. Treatment as prevention (TasP), whereby HIV transmission is prevented by consistent use of HIV treatment and durable viral suppression, has ushered in a new era in worldwide HIV prevention. The combined health benefits of averting new infections and preserving/improving health for PLHIV have translated into rapid scale-up in treatment access across the globe
Interplay between magnetism and superconductivity and appearance of a second superconducting transition in alpha-FeSe at high pressure
We synthesized tetragonal alpha-FeSe by melting a powder mixture of iron and
selenium at high pressure. Subsequent annealing at normal pressure results in
removing traces of hexagonal beta- FeSe, formation of a rather sharp transition
to superconducting state at Tc ~ 7 K, and the appearance of a magnetic
transition near Tm = 120 K. Resistivity and ac-susceptibility were measured on
the annealed sample at hydrostatic pressure up to 4.5 GPa. A magnetic
transition visible in ac-susceptibility shifts down under pressure and the
resistive anomaly typical for a spin density wave (SDW) antiferromagnetic
transition develops near the susceptibility anomaly. Tc determined by the
appearance of a diamagnetic response in susceptibility, increases linearly
under pressure at a rate dTc/dP = 3.5 K/GPa. Below 1.5 GPa, the resistive
superconducting transition is sharp; the width of transition does not change
with pressure; and, Tc determined by a peak in drho/dT increases at a rate ~
3.5 K/GPa. At higher pressure, a giant broadening of the resistive transition
develops. This effect cannot be explained by possible pressure gradients in the
sample and is inherent to alpha-FeSe. The dependences drho(T)/dT show a
signature for a second peak above 3 GPa which is indicative of the appearance
of another superconducting state in alpha-FeSe at high pressure. We argue that
this second superconducting phase coexists with SDW antiferromagnetism in a
partial volume fraction and originates from pairing of charge carriers from
other sheets of the Fermi surface
Gap structure in the electron-doped Iron-Arsenide Superconductor Ba(Fe0.92Co0.08)2As2: low-temperature specific heat study
We report the field and temperature dependence of the low-temperature
specific heat down to 400 mK and in magnetic fields up to 9 T of the
electron-doped Ba(Fe0.92Co0.08)2As2 superconductor. Using the phonon specific
heat obtained from pure BaFe2As2 we find the normal state Sommerfeld
coefficient to be 18 mJ/mol.K^2 and a condensation energy of 1.27 J/mol. The
temperature dependence of the electronic specific heat clearly indicate the
presence of the low-energy excitations in the system. The magnetic field
variation of field-induced specific heat cannot be described by single clean s-
or d-wave models. Rather, the data require an anisotropic gap scenario which
may or may not have nodes. We discuss the implications of these results.Comment: New Journal of Physics in press, 10 pages, 5 figure
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