Capacity of the Region in Enhance Economic Security in the Provision of Food

Goal: to identify and analyze threats to economic security in the food sector of the Republic of Mordovia and their sources.Methods: a systematic approach, economic and statistical analysis, comparative analysis, generalization and interpretation of the results.Results and discussion: the materials of the Republic of Mordovia analyzed the development of agricultural production over the past ten years, identified the main threats to economic security in the field of food supply and their sources, formulated proposals for the prevention and neutralization of threatsConclusions. Conclusions are made about the existence of factors threatening the sustainable development of agriculture of the Republic of Mordovia, which requires the adoption of urgent measures to prevent and neutralize the identified threats

Population Migration in the Context of Economic Security and Social Stability

Target: analysis of migration flows in modern Russia and identification of possible threats to economic security and social stability associated with population migration.Methods: a systematic approach, population analysis, comparative analysis, generalization and interpretation of the results. Results and discussion: On the basis of official statistics and expert estimates, an analysis of the situation in the field of population migration in Russia was carried out, the main directions of population redistribution were identified, the need for adjusting the socio-economic policy in regions experiencing significant migration was substantiated. Conclusions. Conclusions are drawn about the possible increase in the negative impact of migration processes on the socio-economic development of the Russian Federation as a whole and individual regions, in particular, which requires their detailed study in order to take measures to optimize migration flows and adjust social and economic policies

Main Trends and Problems of Human Development in Russia in the Post-Soviet Period

Target. The purpose of this study is to trace the change in Russia’s position in world rankings in terms of humanitarian development, identify the main driving forces, as well as identify problems and suggest ways to solve them.Methods: Methods of demographic and economic and statistical analysis.Results and discussion: Characterized by the dynamics of the human potential of Russia — in 2018, the country first entered the group of countries with a very high level of human development.Выводы: The main problems in human development in the Russian Federation are revealed: low standard of living, long-term permanent decline in real money incomes of Russians (2014–2018), a high degree of material inequality, low life expectancy of the population, high excess mortality of certain categories of the population, a sharp drop in the number of students enrolled in higher education programs, per 1000 people population

Development and Implications of Controlling in the Public Sector

Controlling is essential for public organizations to deliver optimal performance. However, the existing literature lacks sufficient knowledge to help organizations implement better strategies to enhance control. Therefore, this study examined the concept of control in the public sector, its impact on organizational efficiency, and a key focus on implementation. This study adopted a mixed approach (qualitative and quantitative) to study control in the public sector. The literature review was used to gather qualitative data, and a survey was conducted among the managers working in Russian public organizations to determine their responses to controlling practices. The results were compared and analyzed to provide implications and recommendations. It was noted through the results that control in public organizations depends on various factors like controlling approaches and tools, organizational culture, the autonomy of management, and functional control of organizations. Each of these aspects contributes positively toward control and improves public organizations’ efficiency. Therefore, these aspects should be the core focus of public organizations to ensure greater control and efficiency. This research targeted this area to bridge the gap and determine the concept of controlling the Russian public sector. However, this research also has a limitation in that it has surveyed only 102 managers from different Russian public organizations. Doi: 10.28991/ESJ-2023-07-01-015 Full Text: PD

The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBP β

Colorectal cancer is one of the most common cancers in the world. It is well known that the chronic inflammation can promote the progression of colorectal cancer (CRC). Recently, a number of studies revealed a potential association between colorectal inflammation, cancer progression, and infection caused by enterotoxigenic Bacteroides fragilis (ETBF). Bacterial enterotoxin activates spermine oxidase (SMO), which produces spermidine and H2O2 as byproducts of polyamine catabolism, which, in turn, enhances inflammation and tissue injury. Using qPCR analysis, we estimated the expression of SMOX gene and ETBF colonization in CRC patients. We found no statistically significant associations between them. Then we selected genes involved in polyamine metabolism, metabolic reprogramming, and inflammation regulation and estimated their expression in CRC. We observed overexpression of SMOX, ODC1, SRM, SMS, MTAP, c-Myc, C/EBPβ (CREBP), and other genes. We found that two mediators of metabolic reprogramming, inflammation, and cell proliferation c-Myc and C/EBPβ may serve as regulators of polyamine metabolism genes (SMOX, AZIN1, MTAP, SRM, ODC1, AMD1, and AGMAT) as they are overexpressed in tumors, have binding site according to ENCODE ChIP-Seq data, and demonstrate strong coexpression with their targets. Thus, increased polyamine metabolism in CRC could be driven by c-Myc and C/EBPβ rather than ETBF infection

ПРИМЕНЕНИЕ КОЛИЧЕСТВЕННОЙ КОМПЬЮТЕРНОЙ ТОМОГРАФИИ ДЛЯ ВЫЯВЛЕНИЯ НАРУШЕНИЙ МИНЕРАЛЬНОЙ ПЛОТНОСТИ КОСТНОЙ ТКАНИ У ПАЦИЕНТОВ С ПСИХИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ

In clinical practice, the assessment of the cumulative risk of drug-induced osteoporosis in patients with mental disorders is difficult because there are no algorithms to reveal patients with a high risk of antipsychotic-induced osteoporosis and BMD is not evaluated in patients with mental disorders. 95 patients aged from 21 to 60 years with a mental illness duration of at least 12 months on antipsychotics and anticonvulsants therapy were examined. 23 patients (24%) had shown a violation of BMD. There is a significant correlation between the number of risk factors and a decrease in BMD. However, additional study of pharmacogenetic and laboratory data on the risk of osteoporosis is required, which will make it possible to plan therapy more precisely, additionally prescribe drugs that regulate BMD in these categories of patients.Введение. Известно, что одним из факторов возникновения и прогрессирования остеопороза могут быть лекарственные препараты. Некоторые психические заболевания требуют длительного приема антипсихотиков и антиконвульсантов, влияющих на минеральную плотность костной ткани.Цель. Оценить риски развития лекарственно индуцированного остеопороза у больных с психическими расстройствами.Материалы и методы. Проанализированы данные количественной компьютерной томографии у 95 пациентов, находившихся на стационарном лечении в НМИЦ психиатрии и неврологии им. В. М. Бехтерева с длительностью психического заболевания не менее 12 месяцев и принимавших антипсихотики и антиконвульсанты не менее 6 месяцев. Все пациенты прошли клиническое психиатрическое обследование и оценку МПКТ с помощью количественной компьютерной томографии (QCT).Результаты. У 23 пациентов (24%) было выявлено нарушение МПКТ в виде остеопении и остеопороза. Выявлена достоверная зависимость между количеством факторов риска и снижением МПКТ.Заключение. Требуется дополнительное изучение фармакогенетических и лабораторных данных риска остеопороза, учет которых позволит более четко планировать терапию, дополнительно назначать препараты, регулирующие МПКТ у этих категорий больных

EFFICACY AND SAFETY IN THERAPY OF EPILEPSY IN ELDERLY

Abstract: the review substantiates actuality of problem of epilepsy in elderly due to it prevalence in this age population, difficulties of diagnostic which caused by atypical clinical symptoms, subclinical and masked forms of the disease. Principles of rational therapy of epilepsy in elderly with due account the physiological features, comorbidity and co-medication are discussed