An H

Anding AL

Antonucci L

Bergmann TJ

Bernales S

Birgisdottir AB

Bolender RP

Cadwell K

Caldieri G

Chen Q

Chen S

Chino H

Chiramel AI

Cinque L

Codogno P

Cubillos‐Ruiz JR

Diakopoulos KN

Dikic I

Dooley HC

Durr A

English AR

English L

Farre JC

Forrester A

Fregno I

Fry MR

Fujita E

Fumagalli F

Gammoh N

Ganley IG

Ge L

Grumati P

Guan J

Hailey DW

Hamasaki M

Hanna RA

Hayashi-Nishino M

Holcman D

Hotamisligil GS

Houck SA

Huh WJ

Islam F

Jia W

Khaminets A

Koh JH

Kostenko EV

Kurth I

Lamb CA

Lennemann NJ

Liang JR

Linxweiler M

Lipatova Z

Liu XM

Liu Y

Locke M

Martinez J

Mejlvang J

Mijaljica D

Mochida K

Moretti J

Nakatogawa H

Noda T

Ogata M

Oku M

Omari S

Pahl HL

Pang L

Papinski D

Peng Y

Pengo N

Phillips MJ

Polson HEJ

Puri C

Ravenhill BJ

Rello-Varona S

Richter B

Rogov V

Rogov VV

Ruggiano A

Sahu R

Sanjuan MA

Schroeder LK

Schuck S

Schultz ML

Shi Q

Shi W

Smith M

Smith MD

Todd DJ

Tooze J

English

The endoplasmic reticulum (ER) network has central roles in metabolism and cellular organisation. The ER undergoes dynamic alterations in morphology, molecular composition and functional specification. Remodelling of the network under fluctuating conditions enables the continual performance of ER functions and minimises stress. Recent data have revealed that selective autophagy-mediated degradation of ER fragments, or ER-phagy, fundamentally contributes to this remodelling. This review provides a perspective on established views of selective autophagy, comparing these with emerging mechanisms of ER-phagy and related processes. The text discusses the impact of ER-phagy on the function of the ER and the cell, both in normal physiology and when dysregulated within disease settings. Finally, unanswered questions regarding the mechanisms and significance of ER-phagy are highlighted. This article is protected by copyright. All rights reserved.</p

Wilkinson, Simon

Edinburgh Research Explorer

ER-phagy:shaping up and de-stressing the endoplasmic reticulum

Walter P

Wang M

Zachari M

Yla-Anttila P

Yamamoto H

Wild P

Zhang H

Voeltz GK

Yang H

Tschurtschenthaler M

Yang Y

Vargas JNS

Turco E

Crossref

ER‐phagy: shaping up and destressing the endoplasmic reticulum

https://www.pure.ed.ac.uk/ws/files/93481351/ER_phagy_shaping_up_and_de_stressing_the_endoplasmic_reticulum.pdf

ER-phagy:shaping up and de-stressing the endoplasmic reticulum

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