6 research outputs found
Deracemization of Racemic Amine Using ω‑Transaminase and a Nickel-Based Nanocatalyst
Chiral amines are key building blocks for the development
of numerous
bioactive compounds. In this study, we developed a concurrent chemoenzymatic
cascade approach using ω-transaminase for the isomeric configuration
inversion of a racemic amine mixture. One isomer was transaminated
using ω-transaminase, generating coproduct ketones and an additional
chiral substance. Then, the mixture underwent selective reductive
amination of a ketone using a specially designed compatible nickel-based
nanocatalyst, which transformed coproduct ketone to racemic amines
while leaving the opposite enantiomer unchanged. The combination of
the two steps in one reaction system functions as an overall isomeric
configuration inversion system. Moreover, the desired chiral amines
with an additional chiral substance were formed. The procedure consumed
NH3 and generated H2O as the sole byproduct