833 research outputs found
Tropical–North Pacific Climate Linkages over the Past Four Centuries
Analyses of instrumental data demonstrate robust linkages between decadal-scale North Pacific and tropical Indo-Pacific climatic variability. These linkages encompass common regime shifts, including the noteworthy 1976 transition in Pacific climate. However, information on Pacific decadal variability and the tropical high-latitude climate connection is limited prior to the twentieth century. Herein tree-ring analysis is employed to extend the understanding of North Pacific climatic variability and related tropical linkages over the past four centuries. To this end, a tree-ring reconstruction of the December-May North Pacific index (NPI)-an index of the atmospheric circulation related to the Aleutian low pressure cell-is presented (1600-1983). The NPI reconstruction shows evidence for the three regime shifts seen in the instrumental NPI data, and for seven events in prior centuries. It correlates significantly with both instrumental tropical climate indices and a coral-based reconstruction of an optimal tropical Indo-Pacific climate index, supporting evidence for a tropical-North Pacific link extending as far west as the western Indian Ocean. The coral-based reconstruction (1781-1993) shows the twentieth-century regime shifts evident in the instrumental NPI and instrumental tropical Indo-Pacific climate index, and three previous shifts. Changes in the strength of correlation between the reconstructions over time, and the different identified shifts in both series prior to the twentieth century, suggest a varying tropical influence on North Pacific climate, with greater influence in the twentieth century. One likely mechanism is the low-frequency variability of the El Nino-Southern Oscillation (ENSO) and its varying impact on Indo-Pacific climate.</p
Neutrino afterglow from Gamma-Ray Bursts: ~10^{18} eV
We show that a significant fraction of the energy of a gamma-ray burst(GRB)
is probably converted to a burst of 10^{17}-10^{19} eV neutrinos and multiple
GeV gammas that follow the GRB by > 10 s . If, as previously suggested, GRB's
accelerate protons to ~10^{20} eV, then both the neutrinos and the gammas may
be detectable.Comment: Accepted ApJ; added sentence re: sterile neutrinos; related material
at http://www.sns.ias.edu/~jn
Features of Muon Arrival Time Distributions of High Energy EAS at Large Distances From the Shower Axis
In view of the current efforts to extend the KASCADE experiment
(KASCADE-Grande) for observations of Extensive Air Showers (EAS) of primary
energies up to 1 EeV, the features of muon arrival time distributions and their
correlations with other observable EAS quantities have been scrutinised on
basis of high-energy EAS, simulated with the Monte Carlo code CORSIKA and using
in general the QGSJET model as generator. Methodically various correlations of
adequately defined arrival time parameters with other EAS parameters have been
investigated by invoking non-parametric methods for the analysis of
multivariate distributions, studying the classification and misclassification
probabilities of various observable sets. It turns out that adding the arrival
time information and the multiplicity of muons spanning the observed time
distributions has distinct effects improving the mass discrimination. A further
outcome of the studies is the feature that for the considered ranges of primary
energies and of distances from the shower axis the discrimination power of
global arrival time distributions referring to the arrival time of the shower
core is only marginally enhanced as compared to local distributions referring
to the arrival of the locally first muon.Comment: 24 pages, Journal Physics G accepte
On the Discovery of the GZK Cut-off
The recent claim of the '5 sigma' observation of the Greisen and Zatzepin and
Kuzmin cut-off by the HiRes group based on their nine years data is a
significant step toward the eventual solution of the one of the most intriguing
questions which has been present in physics for more than forty years. However
the word 'significance' is used in the mentioned paper in the sense which is
not quite obvious. In the present paper we persuade that this claim is a little
premature.Comment: 10 page
Observing Ultra High Energy Cosmic Particles from Space: SEUSO, the Super Extreme Universe Space Observatory Mission
The experimental search for ultra high energy cosmic messengers, from eV to beyond eV, at the very end of the known energy
spectrum, constitutes an extraordinary opportunity to explore a largely unknown
aspect of our universe. Key scientific goals are the identification of the
sources of ultra high energy particles, the measurement of their spectra and
the study of galactic and local intergalactic magnetic fields. Ultra high
energy particles might, also, carry evidence of unknown physics or of exotic
particles relics of the early universe. To meet this challenge a significant
increase in the integrated exposure is required. This implies a new class of
experiments with larger acceptances and good understanding of the systematic
uncertainties. Space based observatories can reach the instantaneous aperture
and the integrated exposure necessary to systematically explore the ultra high
energy universe. In this paper, after briefly summarising the science case of
the mission, we describe the scientific goals and requirements of the SEUSO
concept. We then introduce the SEUSO observational approach and describe the
main instrument and mission features. We conclude discussing the expected
performance of the mission
Solar panels as air Cherenkov detectors for extremely high energy cosmic rays
Increasing interest towards the observation of the highest energy cosmic rays
has motivated the development of new detection techniques. The properties of
the Cherenkov photon pulse emitted in the atmosphere by these very rare
particles indicate low-cost semiconductor detectors as good candidates for
their optical read-out.
The aim of this paper is to evaluate the viability of solar panels for this
purpose. The experimental framework resulting from measurements performed with
suitably-designed solar cells and large conventional photovoltaic areas is
presented.
A discussion on the obtained and achievable sensitivities follows.Comment: 6 pages, 8 eps figures included with epsfig, uses espcrc2.sty. Talk
given at the Sixth Topical Seminar on Neutrino and Astroparticle Physics, San
Miniato, Italy, 17-21 May 199
Ultra high energy neutrinos from gamma ray bursts
Protons accelerated to high energies in the relativistic shocks that generate
gamma ray bursts photoproduce pions, and then neutrinos in situ. I show that
ultra high energy neutrinos (> 10^19 eV) are produced during the burst and the
afterglow. A larger flux, also from bursts, is generated via photoproduction
off CMBR photons in flight but is not correlated with currently observable
bursts, appearing as a bright background. Adiabatic/synchrotron losses from
protons/pions/muons are negligible. Temporal and directional coincidences with
bursts detected by satellites can separate correlated neutrinos from the
background.Comment: Adiabatic/synchrotron losses from protons/pions/muons shown to be
negligible. Accepted for publication in Phys. Rev. Letters. RevTe
Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy
Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and transcriptional programs that regulate the fate of CAR-T cells after infusion remain poorly understood. Here we perform TCRB sequencing, integration site analysis, and single-cell RNA sequencing (scRNA-seq) to profile CD8+ CAR-T cells from infusion products (IPs) and blood of patients undergoing CD19 CAR-T immunotherapy. TCRB sequencing shows that clonal diversity of CAR-T cells is highest in the IPs and declines following infusion. We observe clones that display distinct patterns of clonal kinetics, making variable contributions to the CAR-T cell pool after infusion. Although integration site does not appear to be a key driver of clonal kinetics, scRNA-seq demonstrates that clones that expand after infusion mainly originate from infused clusters with higher expression of cytotoxicity and proliferation genes. Thus, we uncover transcriptional programs associated with CAR-T cell behavior after infusion.Published versio
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