Searching for BSM neutrino interactions in dark matter detectors

Neutrino interactions beyond the Standard Model (BSM) are theoretically well motivated and have an important impact on the future precision measurement of neutrino oscillation. In this work, we study the sensitivity of a multi-ton-scale liquid Xenon dark matter detector equipped with an intense radiative neutrino source to various BSM neutrino-electron interactions. We consider the conventional Non-Standard Interactions (NSIs), other more generalized four-fermion interactions including scalar and tensor forms, and light-boson mediated interactions. The work shows that with realistic experimental setups, one can achieve unprecedented sensitivity to these BSM neutrino-electron interactions.Comment: fig. 7 added, matches the published versio

Probing Active to Sterile Neutrino Oscillations in the LENS Detector

Sterile neutrino conversion in meter scale baselines can be sensitively probed using monoenergetic, sub-MeV, flavor pure e-neutrinos from an artificial MCi source and the unique technology of LENS designed to oberve the low energy solar neutrino spectrum via tagged CC e-neutrino capture in 115-In. Active-sterile oscillations can be directly observed in the granular LENS detector itself to critically test and extend resuls of short baseline accelerator and reactor experiments.Comment: 4pages, 4 figures, text and figure change

Combining dark matter detectors and electron-capture sources to hunt for new physics in the neutrino sector

In this letter we point out the possibility to study new physics in the neutrino sector using dark matter detectors based on liquid xenon. These are characterized by very good spatial resolution and extremely low thresholds for electron recoil energies. When combined with a radioactive $\nu_e$ source, both features in combination allow for a very competitive sensitivity to neutrino magnetic moments and sterile neutrino oscillations. We find that, for realistic values of detector size and source strength, the bound on the neutrino magnetic moment can be improved by an order of magnitude with respect to the present value. Regarding sterile neutrino searches, we find that most of the gallium anomaly could be explored at the 95% confidence level just using shape information.Comment: 5 pages, 2 figures. Minor modifications, references added. Version accepted for publication in JHE

CLEO Dalitz plot results

Present and future contributions of the CLEO experiment to the study of $D$ Dalitz plots are presented. Such Dalitz plots can be of help in determining weak phases from $B \to D K$ decays.Comment: 4 pages, 6 figures, presented at Beauty 2005, Assisi, Italy, June 20-24, 2005, on behalf of CLEO Collaboration, one reference adde

Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients.

OBJECTIVE:Epigenetic modifications have previously been associated with rheumatoid arthritis (RA). In this study, we aimed to determine whether differential DNA methylation in peripheral blood cell subpopulations is associated with any of 4 clinical outcomes among RA patients. METHODS:Peripheral blood samples were obtained from 63 patients in the University of California, San Francisco RA cohort (all satisfied the American College of Rheumatology classification criteria; 57 were seropositive for rheumatoid factor and/or anti-cyclic citrullinated protein). Fluorescence-activated cell sorting was used to separate the cells into 4 immune cell subpopulations (CD14+ monocytes, CD19+ B cells, CD4+ naive T cells, and CD4+ memory T cells) per individual, and 229 epigenome-wide DNA methylation profiles were generated using Illumina HumanMethylation450 BeadChips. Differentially methylated positions and regions associated with the Clinical Disease Activity Index score, erosive disease, RA Articular Damage score, Sharp score, medication at time of blood draw, smoking status, and disease duration were identified using robust regression models and empirical Bayes variance estimators. RESULTS:Differential methylation of CpG sites associated with clinical outcomes was observed in all 4 cell types. Hypomethylated regions in the CYP2E1 and DUSP22 gene promoters were associated with active and erosive disease, respectively. Pathway analyses suggested that the biologic mechanisms underlying each clinical outcome are cell type-specific. Evidence of independent effects on DNA methylation from smoking, medication use, and disease duration were also identified. CONCLUSION:Methylation signatures specific to RA clinical outcomes may have utility as biomarkers or predictors of exposure, disease progression, and disease severity