Helioseismology of Sunspots: A Case Study of NOAA Region 9787

Various methods of helioseismology are used to study the subsurface properties of the sunspot in NOAA Active Region 9787. This sunspot was chosen because it is axisymmetric, shows little evolution during 20-28 January 2002, and was observed continuously by the MDI/SOHO instrument. (...) Wave travel times and mode frequencies are affected by the sunspot. In most cases, wave packets that propagate through the sunspot have reduced travel times. At short travel distances, however, the sign of the travel-time shifts appears to depend sensitively on how the data are processed and, in particular, on filtering in frequency-wavenumber space. We carry out two linear inversions for wave speed: one using travel-times and phase-speed filters and the other one using mode frequencies from ring analysis. These two inversions give subsurface wave-speed profiles with opposite signs and different amplitudes. (...) From this study of AR9787, we conclude that we are currently unable to provide a unified description of the subsurface structure and dynamics of the sunspot.Comment: 28 pages, 18 figure

Learning Enhancement for Active Student Community Engagement (LEAPSE).

This project explored the potential of public-student engagement to enhance the student experience through active community and public engagement activities. The project evaluates existing models of public engagement activities to build capacity in both the University and communities to gain greater benefit from the potential such co-generative relationships can provide. This project focused on one university with the intention of complementing this primary activity with collecting case study material from a range of contexts. The context for graduate employment is rapidly changing and there is evidence that students derive benefits when their programmes include opportunities for authentic engagement with real-world problems. There is evidence to suggest that communities can benefit from genuine engagement with universities and their staff and students. Over a two-year period at the University of Gloucestershire, the project team worked with academics, students and community groups with the aim that universities and communities can make the most of the relationships and in particular to enhance the students’ experience. This exciting and innovative project worked closely with the National Coordination Centre for Public Engagement to ensure transferability of the project outcomes and to promote outputs from the project. It finds that an estimated 63% students at the University of Gloucestershire are engaged in voluntary work of some kind (63% nationally), of whom, 22% have arranged this through the University or the Student Union (SU) (38 % nationally). Work carried out as part of a project to log voluntary and community engagement across the university involving staff and students has found that approximately 10,000 hours of voluntary work has been carried out in the 2012/13 academic year. The range of work makes understanding and planning this kind of engagement complex. This comprises • Individual self-organised voluntary work, such as brownie or cub scout leadership. • Individual volunteering through a university programme, such as a sports programme working with local teams, or a school mentoring programme (though some of these are paid and therefore not included here). • Individual or team volunteering through Student Union brokerage, such as the SU-run VolunteerShop, campus-based community gardens and an annual tea dance for elderly residents living near the university. • Individual voluntary work within the context of an internship or placement, which may or may not include work for academic credit, such as for a local community project or voluntary organisation, such as the for sports clubs. However, this does not include undergraduate community based research as part of a module that can also account for a considerable contribution of time, effort and expertise

Testimonial Injustice and Vulnerability: A Qualitative Analysis of Participation in the Court of Protection

This article explores participation in Court of Protection (COP) proceedings by people considered vulnerable. The paper is based on original data obtained from observing COP proceedings and reviewing COP case files. It is argued that the observed absence of the subject of proceedings is a form of testimonial injustice, that is, a failure to value a person in their capacity as a giver of knowledge. The issue of competence to give evidence is considered but it is argued that it is not the formal evidential rules that prohibit a vulnerable adult from giving evidence. Instead, it is the result of a persistent assumption that they are inherently vulnerable and therefore lack credibility as a knowledge giver. This assumption results in the voices of vulnerable adults being routinely absent from legal proceedings. It is argued that having a voice in the courtroom is essential and has a number of intrinsic and instrumental benefits. The paper concludes with a discussion about the implications of the research, including the current trend towards the increased use of special measures, and recommends a presumption in favour of the subject of COP proceedings giving evidence

LocoMMotion: a prospective, non-interventional, multinational study of real-life current standards of care in patients with relapsed and/or refractory multiple myeloma

Despite treatment advances, patients with multiple myeloma (MM) often progress through standard drug classes including proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs), and anti-CD38 monoclonal antibodies (mAbs). LocoMMotion (ClinicalTrials.gov identifier: NCT04035226) is the first prospective study of real-life standard of care (SOC) in triple-class exposed (received at least a PI, IMiD, and anti-CD38 mAb) patients with relapsed/refractory MM (RRMM). Patients (N = 248; ECOG performance status of 0–1, ≥3 prior lines of therapy or double refractory to a PI and IMiD) were treated with median 4.0 (range, 1–20) cycles of SOC therapy. Overall response rate was 29.8% (95% CI: 24.2–36.0). Median progression-free survival (PFS) and median overall survival (OS) were 4.6 (95% CI: 3.9–5.6) and 12.4 months (95% CI: 10.3–NE). Treatment-emergent adverse events (TEAEs) were reported in 83.5% of patients (52.8% grade 3/4). Altogether, 107 deaths occurred, due to progressive disease (n = 74), TEAEs (n = 19), and other reasons (n = 14). The 92 varied regimens utilized demonstrate a lack of clear SOC for heavily pretreated, triple-class exposed patients with RRMM in real-world practice and result in poor outcomes. This supports a need for new treatments with novel mechanisms of action