Results of a 0.03- scale aerodynamic characteristics investigation of Boeing 747 carrier (model no. AX 1319 I-1) mated with a space shuttle orbiter (model 45-0) conducted in the Boeing transonic wind tunnel (CA5), volume 1

The performance, stability, and control characteristics of various carrier aircraft configurations are presented. Aerodynamic characteristics of the carrier mated with the Orbiter, carrier alone, and Orbiter alone were investigated. Carrier support system tare and interference effects were determined. Six-component force and moment data were recorded for the carrier and Orbiter. Buffet onset characteristics of the carrier vertical tail and horizontal tail were recorded. Angles of attack from -3 deg through 26 deg and angles of slideslip between +12 deg and -12 deg were investigated at Mach numbers from 0.15 through 0.70. Photographs are included

Anharmonicity and self-similarity of the free energy landscape of protein G

The near-native free energy landscape of protein G is investigated through 0.4 microseconds-long atomistic molecular dynamics simulations in explicit solvent. A theoretical and computational framework is used to assess the time-dependence of salient thermodynamical features. While the quasi-harmonic character of the free energy is found to degrade in a few ns, the slow modes display a very mild dependence on the trajectory duration. This property originates from a striking self-similarity of the free energy landscape embodied by the consistency of the principal directions of the local minima, where the system dwells for several ns, and of the virtual jumps connecting them.Comment: revtex, 6 pages, 5 figure

Shuttle model tailcone pressure distribution at low subsonic speeds of a 0.03614-scale model in the NASA/LaRC low-turbulence pressure tunnel (LA81), volume 1

An investigation was conducted in the NASA/LaRC Low-Turbulence Pressure Tunnel on a 0.03614-scale orbiter model of a 089B configuration with a 139B configuration nose forward of F.S. 500. The tailcone was the TC sub 4 design and was instrumented with eighty-nine pressure orifices. Control surfaces were deflected and three wind tunnel mounting techniques were investigated over an angle-of-attack range from -2 deg to a maximum of 18 deg. In order to determine the sensitivity of the tailcone to changes in Reynolds number, most of the test was made at a Mach number of 0.20 over a Reynolds number range of 2.0 to 10 million per foot. A few runs were made at a Mach number of 0.30 at Reynolds numbers of 4.0, 6.0, and 8 million per foot

Shuttle model tailcone pressure distribution at low subsonic speeds of a 0.03614-scale model in the NASA/LaRC low-turbulence pressure tunnel (LA81), volume 2

For abstract, see Vol 1

Upper wing surface boundary layer measurements and static aerodynamic data obtained on a 0.015-scale model (42-0) or the SSV orbiter configuration 140A/B in the LTV HSWT at a Mach number of 4.6 (LA58)

The purpose of the test was to investigate the nature of the Orbiter boundary layer characteristics at angles of attack from -4 to 32 degrees at a Mach number of 4.6. The effect of large grit, employed as transition strips, on both the nature of the boundary layer and the force and moment characteristics were investigated along with the effects of large negative elevon deflection on lee side separation. In addition, laminar and turbulent boundary layer separation phenomena which could cause asymmetric flow separation were investigated

Results of a 0.03-scale aerodynamic characteristics investigation of a Boeing 747 carrier (model no. AX 1319 I-1) mated with a space shuttle orbiter (model 45-0) conducted in the Boeing transonic wind tunnel (CA5), volume 2

For abstract, see N75-33162

Results of a 0.03-scale aerodynamic characteristics investigation of a Boeing 747 carrier (model no. AX 1319 I-1) mated with a space shuttle orbiter (model 45-0) conducted in the Boeing transonic wind tunnel (CA5)

For abstract, see N75-33162

Uptake and degradation of mast-cell granules by mouse peritoneal macrophages

35S-labelled mast-cell granules isolated from mouse mastocytomas were added to mouse macrophages in vitro. The granules were avidly phagocytosed, and subsequently the radioactivity was released to the medium as inorganic [35S]sulphate. After pulse-labelling, a total of about 80% of the cell-associated radioactivity was thus released in the course of 24 h, indicating an extensive breakdown of the sulphated polysaccharides, mainly heparin, present in the granules. The uptake of the mast-cell granules caused pronounced, but reversible, spreading of the macrophages

Influence of conformational fluctuations on enzymatic activity: modelling the functional motion of beta-secretase

Considerable insight into the functional activity of proteins and enzymes can be obtained by studying the low-energy conformational distortions that the biopolymer can sustain. We carry out the characterization of these large scale structural changes for a protein of considerable pharmaceutical interest, the human $\beta$-secretase. Starting from the crystallographic structure of the protein, we use the recently introduced beta-Gaussian model to identify, with negligible computational expenditure, the most significant distortion occurring in thermal equilibrium and the associated time scales. The application of this strategy allows to gain considerable insight into the putative functional movements and, furthermore, helps to identify a handful of key regions in the protein which have an important mechanical influence on the enzymatic activity despite being spatially distant from the active site. The results obtained within the Gaussian model are validated through an extensive comparison against an all-atom Molecular Dynamics simulation.Comment: To be published in a special issue of J. Phys.: Cond. Mat. (Bedlewo Workshop