16 research outputs found
The M\u3csub\u3er\u3c/sub\u3e-value of chloroplast coupling factor 1
The Mr of spinach chloroplast coupling factor 1 has been determined by sedimentation equilibrium and by light scattering to be 400 000 ± 24 600 and 407 000 ± 20 000, respectively. These values differ substantially from that obtained previously (325 000) and are consistent with an α3β3γδε{lunate} subunit stoichiometry. © 1983
CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished internalization of Aβ42) (2) accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging and (3), increased numbers of activated human microglia
Readings bookstore trials new e-books technology
Melbourne company, Inventive Labs, has developed new technology to help independent booksellers thrive in the brave new world of e-books.
Large multi-nationals like Borders are paying a high price for failing to keep pace with the digital changes in the way shoppers buy books. Its online struggle has proved critical as consumers become more accustomed to buying and downloading electronic books.
Guests
Stephen PageChief Executive Faber and FaberUK publisher
Viriginia MurdochCo-director, Inventive LabMelbourne
Michael TamblynVice President of Content Sales and MarketingKobo, a Canadian online ebook retailer
Andrew McDonaldOnline ManagerReadings Bookstor
From "crisis to recovery": A complete insight into the mechanisms of chlorine injury in the lung.
Chlorine (Cl2) gas is a toxic industrial chemical (TIC) that poses a hazard to human health following accidental and/or intentional (e.g. terrorist) release. By using a murine model of sub-lethal Cl2 exposure we have examined the airway hyper responsiveness, cellular infiltrates, transcriptomic and proteomic responses of the lung. In the "crisis" phase at 2Â h and 6Â h there is a significant decreases in leukocytes within bronchoalveolar lavage fluid accompanied by an upregulation within the proteome of immune pathways ultimately resulting in neutrophil influx at 24Â h. A flip towards "repair" in the transcriptome and proteome occurs at 24Â h, neutrophil influx and an associated drop in the lung function persisting until 14 d post-exposure and subsequent "recovery" after 28Â days. Collectively, this research provides new insights into the mechanisms of damage, early global responses and processes of repair induced in the lung following the inhalation of Cl2