Slowly-growing gap-opening planets trigger weaker vortices

The presence of a giant planet in a low-viscosity disc can create a gap edge in the disc's radial density profile sharp enough to excite the Rossby Wave Instability. This instability may evolve into dust-trapping vortices that might explain the "banana-shaped" features in recently observed asymmetric transition discs with inner cavities. Previous hydrodynamical simulations of planet-induced vortices have neglected the timescale of hundreds to thousands of orbits to grow a massive planet to Jupiter-size. In this work, we study the effect of a giant planet's runaway growth timescale on the lifetime and characteristics of the resulting vortex. For two different planet masses (1 and 5 Jupiter masses) and two different disc viscosities ($\alpha$=3$\times 10^{-4}$ and 3$\times10^{-5}$), we compare the vortices induced by planets with several different growth timescales between 10 and 4000 planet orbits. In general, we find that slowly-growing planets create significantly weaker vortices with lifetimes and surface densities reduced by more than $50\%$. For the higher disc viscosity, the longest growth timescales in our study inhibit vortex formation altogether. Additionally, slowly-growing planets produce vortices that are up to twice as elongated, with azimuthal extents well above $180^{\circ}$ in some cases. These unique, elongated vortices likely create a distinct signature in the dust observations that differentiates them from the more concentrated vortices that correspond to planets with faster growth timescales. Lastly, we find that the low viscosities necessary for vortex formation likely prevent planets from growing quickly enough to trigger the instability in self-consistent models.Comment: 12 pages, 7 figures, Accepted by MNRA

Observational diagnostics of elongated planet-induced vortices with realistic planet formation timescales

Gap-opening planets can generate dust-trapping vortices that may explain some of the latest discoveries of high-contrast crescent-shaped dust asymmetries in transition discs. While planet-induced vortices were previously thought to have concentrated shapes, recent computational work has shown that these features naturally become much more elongated in the gas when simulations account for the relatively long timescale over which planets accrete their mass. In this work, we conduct two-fluid hydrodynamical simulations of vortices induced by slowly-growing Jupiter-mass planets in discs with very low viscosity ($\alpha = 3 \times 10^{-5}$). We simulate the dust dynamics for four particle sizes spanning 0.3 mm to 1 cm in order to produce synthetic ALMA images. In our simulations, we find that an elongated vortex still traps dust, but not directly at its center. With a flatter pressure bump and disruptions from the planet's overlapping spiral density waves, the dust instead circulates around the vortex. This motion (1) typically carries the peak off-center, (2) spreads the dust out over a wider azimuthal extent $\geq 180^{\circ}$, (3) skews the azimuthal profile towards the front of the vortex, and (4) can also create double peaks in newly-formed vortices. In particular, we expect that the most defining observational signature, a peak offset of more than $30^{\circ}$, should be detectable $>30\%$ of the time in observations with a beam diameter of at most the planet's separation from its star.Comment: Accepted to MNRAS. 13 pages, 8 figures. Movies available at: https://lavinia.as.arizona.edu/~mhammer/vortex_signatures.htm

Electronic transport in quasi-one-dimensional arrays of gold nanocrystals

We report on the fabrication and current-voltage (IV) characteristics of very narrow, strip-like arrays of metal nanoparticles. The arrays were formed from gold nanocrystals self-assembled between in-plane electrodes. Local cross-linking of the ligands by exposure to a focused electron beam and subsequent removal of the unexposed regions produced arrays as narrow as four particles wide and sixty particles long, with high degree of structural ordering. Remarkably, even for such quasi-one-dimensional strips, we find nonlinear, power-law IV characteristics similar to that of much wider two-dimensional (2D) arrays. However, in contrast to the robust behavior of 2D arrays, the shape of the IV characteristics is much more sensitive to temperature changes and temperature cycling. Furthermore, at low temperatures we observe pronounced two-level current fluctuations, indicative of discrete rearrangements in the current paths. We associate this behavior with the inherent high sensitivity of single electron tunneling to the polarization caused by the quenched offset charges in the underlying substrate.Comment: 5 pages, 4 figure

Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer.

BackgroundPancreatic cancer is one of the most lethal malignancies due to frequent late diagnosis, aggressive tumor growth and metastasis formation. Continuously raising incidence rates of pancreatic cancer and a lack of significant improvement in survival rates over the past 30 years highlight the need for new therapeutic agents. Thus, new therapeutic agents and strategies are urgently needed to improve the outcome for patients with pancreatic cancer. Here, we evaluated the anti-tumor activity of a new natural product-based epidithiodiketopiperazine, NT1721, against pancreatic cancer.MethodsWe characterized the anticancer efficacy of NT1721 in multiple pancreatic cancer cell lines in vitro and in two orthotopic models. We also compared the effects of NT1721 to clinically used hedgehog inhibitors and the standard-of-care drug, gemcitabine. The effect of NT1721 on hedgehog/GLI signaling was assessed by determining the expression of GLI and GLI target genes both in vitro and in vivo.ResultsNT1721 displayed IC50 values in the submicromolar range in multiple pancreatic cancer cell lines, while largely sparing normal pancreatic epithelial cells. NT1721 attenuated hedgehog/GLI signaling through downregulation of GLI1/2 transcription factors and their downstream target genes, which reduced cell proliferation and invasion in vitro and significantly decreased tumor growth and liver metastasis in two preclinical orthotopic mouse models of pancreatic cancer. Importantly, treatment with NT1721 significantly improved survival times of mice with pancreatic cancer compared to the standard-of-care drug, gemcitabine.ConclusionsFavorable therapeutics properties, i.e. 10-fold lower IC50 values than clinically used hedgehog inhibitors (vismodegib, erismodegib), a 90% reduction in liver metastasis and significantly better survival times compared to the standard-of-care drug, gemcitabine, provide a rational for testing NT1721 in the clinic either as a single agent or possibly in combination with gemcitabine or other therapeutic agents in PDAC patients overexpressing GLI1/2. This could potentially result in promising new treatment options for patients suffering from this devastating disease

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia.

Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined. The Innate immune system can be activated by endogenous nucleic acids from non-processed pre-rRNAs, DNA damage, and apoptosis that occurs in DBA. Recognition by toll like receptors (TLRs) and Mda5-like sensors induces interferons (IFNs) and inflammation. Dying cells can also activate complement system. Therefore we analyzed the status of these pathways in RP-deficient zebrafish and found upregulation of interferon, inflammatory cytokines and mediators, and complement. We also found upregulation of receptors signaling to IFNs including Mda5, Tlr3, and Tlr9. TGFb family member activin was also upregulated in RP-deficient zebrafish and in RPS19-deficient human cells, which include a lymphoid cell line from a DBA patient, and fetal liver cells and K562 cells transduced with RPS19 shRNA. Treatment of RP-deficient zebrafish with a TLR3 inhibitor decreased IFNs activation, acute phase response, and apoptosis and improved their hematopoiesis and morphology. Inhibitors of complement and activin also had beneficial effects. Our studies suggest that innate immune system contributes to the phenotype of RPS19-deficient zebrafish and human cells

Exploration of nonlocalities in ensembles consisting of bipartite quantum states

It is revealed that ensembles consisting of multipartite quantum states can exhibit different kinds of nonlocalities. An operational measure is introduced to quantify nonlocalities in ensembles consisting of bipartite quantum states. Various upper and lower bounds for the measure are estimated and the exact values for ensembles consisting of mutually orthogonal maximally entangled bipartite states are evaluated.Comment: The title and some contents changed, 4 pages, no figure

Dynamical Self-assembly during Colloidal Droplet Evaporation Studied by in situ Small Angle X-ray Scattering

The nucleation and growth kinetics of highly ordered nanocrystal superlattices during the evaporation of nanocrystal colloidal droplets was elucidated by in situ time resolved small-angle x-ray scattering. We demonstrated for the first time that evaporation kinetics can affect the dimensionality of the superlattices. The formation of two-dimensional nanocrystal superlattices at the liquid-air interface of the droplet has an exponential growth kinetics that originates from interface "crushing".Comment: 4 pages, 4 figure

Percolating through networks of random thresholds: Finite temperature electron tunneling in metal nanocrystal arrays

We investigate how temperature affects transport through large networks of nonlinear conductances with distributed thresholds. In monolayers of weakly-coupled gold nanocrystals, quenched charge disorder produces a range of local thresholds for the onset of electron tunneling. Our measurements delineate two regimes separated by a cross-over temperature $T^*$. Up to $T^*$ the nonlinear zero-temperature shape of the current-voltage curves survives, but with a threshold voltage for conduction that decreases linearly with temperature. Above $T^*$ the threshold vanishes and the low-bias conductance increases rapidly with temperature. We develop a model that accounts for these findings and predicts $T^*$.Comment: 5 pages including 3 figures; replaced 3/30/04: minor changes; final versio

Isomorphism of graph classes related to the circular-ones property

We give a linear-time algorithm that checks for isomorphism between two 0-1 matrices that obey the circular-ones property. This algorithm leads to linear-time isomorphism algorithms for related graph classes, including Helly circular-arc graphs, \Gamma-circular-arc graphs, proper circular-arc graphs and convex-round graphs.Comment: 25 pages, 9 figure