50 research outputs found
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Machine learning-driven web-post buckling resistance prediction for high-strength steel beams with elliptically-based web openings
The use of periodical elliptically-based web (EBW) openings in high strength steel (HSS) beams has been increasingly popular in recent years mainly because of the high strength-to-weight ratio and the reduction in the floor height as a result of allowing different utility services to pass through the web openings. However, these sections are susceptible to web-post buckling (WPB) failure mode and therefore it is imperative that an accurate design tool is made available for prediction of the web-post buckling capacity. Therefore, the present paper aims to implement the power of various machine learning (ML) methods for prediction of the WPB capacity in HSS beams with (EBW) openings and to assess the performance of existing analytical design model. For this purpose, a numerical model is developed and validated with the aim of conducting a total of 10,764 web-post finite element models, considering S460, S690 and S960 steel grades. This data is employed to train and validate different ML algorithms including Artificial Neural Networks (ANN), Support Vector Machine Regression (SVR) and Gene Expression Programming (GEP). Finally, the paper proposes new design models for WPB resistance prediction. The results are discussed in detail, and they are compared with the numerical models and the existing analytical design method. The proposed design models based on the machine learning predictions are shown to be powerful, reliable and efficient design tools for capacity predictions of the WPB resistance of HSS beams with periodical (EBW) openings
The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration
Superoxide dismutase (SOD1) gene variants may cause amyotrophic lateral sclerosis, some of which are associated with a distinct phenotype. Most studies assess limited variants or sample sizes. In this international, retrospective observational study, we compare phenotypic and demographic characteristics between people with SOD1-ALS and people with ALS and no recorded SOD1 variant. We investigate which variants are associated with age at symptom onset and time from onset to death or censoring using Cox proportional-hazards regression. The SOD1-ALS dataset reports age of onset for 1122 and disease duration for 883 people; the comparator population includes 10,214 and 9010 people respectively. Eight variants are associated with younger age of onset and distinct survival trajectories; a further eight associated with younger onset only and one with distinct survival only. Here we show that onset and survival are decoupled in SOD1-ALS. Future research should characterise rarer variants and molecular mechanisms causing the observed variability
The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration
Superoxide dismutase (SOD1) gene variants may cause amyotrophic lateral sclerosis, some of which are associated with a distinct phenotype. Most studies assess limited variants or sample sizes. In this international, retrospective observational study, we compare phenotypic and demographic characteristics between people with SOD1-ALS and people with ALS and no recorded SOD1 variant. We investigate which variants are associated with age at symptom onset and time from onset to death or censoring using Cox proportional-hazards regression. The SOD1-ALS dataset reports age of onset for 1122 and disease duration for 883 people; the comparator population includes 10,214 and 9010 people respectively. Eight variants are associated with younger age of onset and distinct survival trajectories; a further eight associated with younger onset only and one with distinct survival only. Here we show that onset and survival are decoupled in SOD1-ALS. Future research should characterise rarer variants and molecular mechanisms causing the observed variability