32 research outputs found
Diagnóstico das condições de saúde bucal em portadores de paralisia cerebral do municÃpio de Pelotas, Rio Grande do Sul, Brasil
Solanum paniculatum L. (Jurubeba): Potent inhibitor of gastric acid secretion in mice
Solanum paniculatum L. is used commonly in Brazilian folk medicine for the treatment of liver and gastrointestinal disorders. the freeze-dried aqueous extracts (WEs) obtained from distinct parts of the plant (flowers, fruits, leaves, stems and roots) were tested to determine their antiulcer and antisecretory gastric acid activities using mice. the aqueous extracts of roots, stems and flowers inhibited gastric acid secretion in pylorus-ligated mice with ED50 values of 418, 777 and 820 mg/kg body wt. (i.d.), respectively. Extracts of leaves (0.5-2 g/kg body wt., Ld) did not affect gastric secretion, whereas fruit extracts (0.5-2 g/kg body wt., U) stimulated gastric acid secretion. the stimulatory effect of the fruit extract was inhibited by pretreatment with atropine (5 mg/kg body wt., i.m.) but not with ranitidine (80 mg/kg body wt., i.p.) suggesting that the fruit extract activates the muscarinic pathway of gastric acid secretion. in contrast, administration of the root extract into the duodenal lumen inhibited histamine- and bethanechol-induced gastric secretion in pylorus-ligated mice. in addition, the aqueous extract of roots (ED50 value, 1.2 g/kg body wt., p.o.) protected the animals against production of gastric lesions subsequent to the hypersecretion induced in mice by stress following cold restraint. This effect was not reproduced when the lesions were induced by blockade of prostaglandins synthesis via subcutaneous injection of indomethacin. Thus, antiulcer activity of the plant extracts appears to be related directly to a potent anti-secretory activity. No toxic signs were observed following administration of different extracts up to 2 g/kg body wt., p.o. Collectively, the results validate folk use of Solanum paniculatum L. plant to treat gastric disorders.Universidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, Nat Prod Sect, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, Nat Prod Sect, São Paulo, BrazilWeb of Scienc
Peripheral venous access using devices over needles with and without extension: costs and outcomes
Risk factors for site complications of intravenous therapy in children and adolescents with cancer
Capacidade funcional no idoso longevo: uma revisão integrativa
Trata-se de revisão integrativa da literatura, cujo objetivo foi conhecer a produção cientÃfica brasileira referente à capacidade funcional do idoso longevo. Foram consultadas as bases de dados BDENF, LILACS, MEDLINE e SciELO, no perÃodo amostral de janeiro de 2001 a setembro de 2010. Foram selecionados oito artigos, sendo os profissionais enfermeiros (4) os principais autores das publicações. O ano de publicação dos artigos variou entre 2006 e 2010, e houve predominância da pesquisa quantitativa com enfoque na multidimensionalidade do idoso. Foram utilizados questionários e escalas para avaliar a capacidade funcional dos longevos e indicados os fatores limitantes para o desempenho dessa capacidade. A produção cientÃfica na temática é incipiente, o que demonstra a necessidade de novas pesquisas, com vistas à melhoria na qualidade de vida dos idosos longevos.