Right and left ventricular function and myocardial scarring in adult patients with sickle cell disease: a comprehensive magnetic resonance assessment of hepatic and myocardial iron overload

Background: Patients with Sickle cell disease (SCD) who receive regular transfusions are at risk for developing cardiac toxicity from iron overload. The aim of this study was to assess right and left cardiac volumes and function, late gadolinium enhancement (LGE) and iron deposits in patients with SCD using CMR, correlating these values with transfusion burden, ferritin and hemoglobin levels. Methods: Thirty patients with SCD older than 20 years of age were studied in a 1.5 T scanner and compared to age- and sex-matched normal controls. Patients underwent analysis of biventricular volumes and function, LGE and T2* assessment of the liver and heart. Results: When compared to controls, patients with SCD presented higher left ventricular (LV) volumes with decreased ejection fraction (EF) with an increase in stroke volume (SV) and LV hypertrophy. The right ventricle (RV) also presented with a decreased EF and hypertrophy, with an increased end-systolic volume. Although twenty-six patients had increased liver iron concentrations (median liver iron concentration value was 11.83 +/- 9.66 mg/g), only one patient demonstrated an abnormal heart T2* < 20 msec. Only four patients (13%) LGE, with only one patient with an ischemic pattern. Conclusions: Abnormal heart iron levels and myocardial scars are not a common finding in SCD despite increased liver iron overload. The significantly different ventricular function seen in SCD compared to normal suggests the changes in RV and LV function may not be due to the anemia alone. Future studies are necessary to confirm this association.1

Avaliação de um sistema de segunda opinião em radiologia Evaluation of a second opinion system in radiology

OBJETIVO: A segunda opinião médica pode auxiliar no processo de investigação do problema de saúde de um paciente e na definição da conduta terapêutica. Este trabalho tem por objetivo demonstrar um processo de segunda opinião médica por meio de um sistema web multiespecialidades adaptado para a radiologia. MATERIAIS E MÉTODOS: O sistema foi utilizado por 49 médicos residentes da Universidade Federal de São Paulo, os quais responderam a 52 solicitações de segunda opinião. Como instrumentos de avaliação foram utilizados questionários. RESULTADOS: Foram avaliadas 1.704 respostas de segunda opinião. Deste total, 514 (29,1%) foram definidas como satisfatórias. Em 64,4% as respostas dos questionários indicaram que a qualidade das imagens não comprometeu o diagnóstico. O tempo médio para emitir a segunda opinião remota foi de 6 minutos e 26 segundos. CONCLUSÃO: O processo de segunda opinião médica realizado por intermédio de um sistema web multiespecialidades ajustado para a radiologia pode ser uma excelente ferramenta para o manejo das condutas médicas.<br>OBJECTIVE: A second medical opinion can aid in the investigation of a health problem as well as in the definition of the therapeutic approach. The present study is aimed at demonstrating a process of second medical opinion by means of a web-based multispecialty system adapted for radiology. MATERIALS AND METHODS: The system was utilized by 49 residents at Universidade Federal de São Paulo, Brazil, who gave their medical opinion on 52 second opinion requests. Questionnaires were utilized as an evaluation tool. RESULTS: A total of 1704 medical second opinions were evaluated and 514 (29.1%) of them were defined as satisfactory. In 64.4% of cases, the answers of the questionnaires indicated that the images quality did not affect the diagnosis. On average, 6 minutes and 26 seconds was the time required to issue a remote second medical opinion. CONCLUSION: A process of second medical opinion by means of a web-based multispecialty system adapted for radiology has shown to be an excellent tool in the management of therapeutic approaches