MANUFACTURING EMPLOYEES' BIG FIVE PERSONALITY DIMENSIONS AND THEIR RELATIONSHIP TO JOB SATISFACTION

Earlier studies have indicated that employees' personalities influence their job satisfaction. Thus, this study aims to examine the relationship between the Big Five personality dimensions and job satisfaction in the manufacturing industry. This study also intends to determine which personality dimension is closely related to job satisfaction. 106 employees from the manufacturing industry in Muar, Johor were selected randomly to complete the Big Five personality questionnaire (NEO-FFI-3) and Minnesota Satisfaction Scale (MSQ). The result revealed that only extraversion, openness and conscientiousness are significantly correlated to employees' job satisfaction. Conscientiousness is the closest dimension related to job satisfaction. This quantitative study provides new empirical evidence and contributions to the manufacturing industry

Assessment of weight gain and its association with dietary intake, physical activities and sociodemographic factors among pregnant women in bachok district, Kelantan

Pregnancy is a unique period where there is a dynamic change of physiological phenomenon of a pregnant woman to accommodate the fetus development. Appropriate gestational weight gain during pregnancy is crucial for healthy development of fetus and also to reduce the incidence of adverse maternal and neonatal outcomes. This study aimed to assess the associated factors of gestational weight gain among third trimester pregnant women in Bachok District, Kelantan. Pregnant women in their third trimester were recruited from government healthcare clinic in Bachok District and were followed-up after delivery. A total of 211 pregnant women aged 19-49 years with singleton pregnancy were included in the study. Maternal sociodemographic characteristics, dietary intake, physical activity level and anthropometric measurements were collected through face-to-face interview. Multinomial logistic regression analysis was performed to identify the associated factors of gestational weight gain during pregnancy. Findings showed that higher maternal age (30-49) was associated with 2.57 times (95% CI 1.27, 5.19) to develop inadequate gestational weight gain, while overweight and obese pregnant women were at 72.2% (95% CI 0.10, 0.75) and 72.9% (95% CI 0.08, 0.97), respectively lower incidence of developing inadequate gestational weight gain. In the other hand, higher household size (≥ 6) was associated with 59.6% (95% CI 0.18,0.89) lower chance of developing excessive weight gain. However, pregnant women with mid-upper arm circumference ≥ 27cm were associated with 7.13 times (95% CI 1.60, 31.68) greater chance to develop excessive gestational weight gain. In conclusion, maternal age, household size, prepregnancy body mass index and midupper arm circumference measurement were significantly associated with gestational weight gain. Proper counseling on recommended weight gain during pregnancy as well as healthy dietary intake and recommended physical activity may lead to an appropriate gestational weight gain within recommendations and reduce the complication of maternal and neonatal outcomes

Fine-tuning Large Language Model (LLM) Artificial Intelligence Chatbots in Ophthalmology and LLM-based evaluation using GPT-4

Purpose: To assess the alignment of GPT-4-based evaluation to human clinician experts, for the evaluation of responses to ophthalmology-related patient queries generated by fine-tuned LLM chatbots. Methods: 400 ophthalmology questions and paired answers were created by ophthalmologists to represent commonly asked patient questions, divided into fine-tuning (368; 92%), and testing (40; 8%). We find-tuned 5 different LLMs, including LLAMA2-7b, LLAMA2-7b-Chat, LLAMA2-13b, and LLAMA2-13b-Chat. For the testing dataset, additional 8 glaucoma QnA pairs were included. 200 responses to the testing dataset were generated by 5 fine-tuned LLMs for evaluation. A customized clinical evaluation rubric was used to guide GPT-4 evaluation, grounded on clinical accuracy, relevance, patient safety, and ease of understanding. GPT-4 evaluation was then compared against ranking by 5 clinicians for clinical alignment. Results: Among all fine-tuned LLMs, GPT-3.5 scored the highest (87.1%), followed by LLAMA2-13b (80.9%), LLAMA2-13b-chat (75.5%), LLAMA2-7b-Chat (70%) and LLAMA2-7b (68.8%) based on the GPT-4 evaluation. GPT-4 evaluation demonstrated significant agreement with human clinician rankings, with Spearman and Kendall Tau correlation coefficients of 0.90 and 0.80 respectively; while correlation based on Cohen Kappa was more modest at 0.50. Notably, qualitative analysis and the glaucoma sub-analysis revealed clinical inaccuracies in the LLM-generated responses, which were appropriately identified by the GPT-4 evaluation. Conclusion: The notable clinical alignment of GPT-4 evaluation highlighted its potential to streamline the clinical evaluation of LLM chatbot responses to healthcare-related queries. By complementing the existing clinician-dependent manual grading, this efficient and automated evaluation could assist the validation of future developments in LLM applications for healthcare.Comment: 13 Pages, 1 Figure, 8 Table

Study of early changes in intraocular pressure following phacoemulsification

: To evaluate early postoperative changes in intraocular pressure (IOP) following phacoemulsification and intraocular lens (IOL) implantation. Method: This retrospective and observational study included 100 patients with normal IOP underwent uneventful standard phacoemulsification procedure for senile cataracts at Sarawak General Hospital over a period of six months from July 2017 to December 2017. Patient's data were retrieved from Eye Clinic records. All patients were checked for IOP with Goldmann tonometry during pre-operative assessment and one month postoperatively. Patients with pre-existing IOP related ocular disease or intraocular surgery were excluded. Effects of age, gender, comorbidity of diabetes mellitus and hypertension, eye laterality, ocular axial length and pre-operative IOP on post-operative IOP reduction were analysed. Results: Phacoemulsification was found to reduce IOP by mean of 1.07 mmHg, which was statistically significant (P < 0.001). A larger IOP reduction was seen in cases with a higher pre-operative IOP (P 0.05). Conclusion: Phacoemulsification had a significant IOP-lowering effect in normal subjects, in particular in higher pre-operative IOP. There was no correlation between age, gender, comorbidity of diabetes mellitus or hypertension, eye laterality, and ocular axial length to IOP reduction following hacoemulsification

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

IL11 initiates fibroblast activation but also causes epithelial cell dysfunction. The mechanisms underlying these processes are not known. We report that IL11-stimulated ERK/P90RSK activity causes the phosphorylation of LKB1 at S325 and S428, leading to its inactivation. This inhibits AMPK and activates mTOR across cell types. In stromal cells, IL11-stimulated ERK activity inhibits LKB1/AMPK which is associated with mTOR activation, ⍺SMA expression, and myofibroblast transformation. In hepatocytes and epithelial cells, IL11/ERK activity inhibits LKB1/AMPK leading to mTOR activation, SNAI1 expression, and cell dysfunction. Across cells, IL11-induced phenotypes were inhibited by metformin stimulated AMPK activation. In mice, genetic or pharmacologic manipulation of IL11 activity revealed a critical role of IL11/ERK signaling for LKB1/AMPK inhibition and mTOR activation in fatty liver disease. These data identify the IL11/mTOR axis as a signaling commonality in stromal, epithelial, and cancer cells and reveal a shared IL11-driven mesenchymal program across cell types

Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy.

Cancer-related cognitive impairment (CRCI) adversely affects cancer patients. We had previously demonstrated that the BDNF Val66Met genetic polymorphism is associated with lower odds of subjective CRCI in the multitasking and verbal ability domains among breast cancer patients receiving chemotherapy. To further assess our previous findings, we evaluated the association of BDNF Val66Met polymorphism with subjective and objective CRCI in a temporally separate cohort of patients and pooled findings from both the original (n = 145) and current (n = 193) cohorts in a meta-analysis. Subjective CRCI was assessed using FACT-Cog. Objective CRCI was evaluated using computerized neuropsychological tests. Genotyping was carried out using Sanger sequencing. The association of BDNF Val66Met genotypes and CRCI was examined with logistic regression. A fixed-effect meta-analysis was conducted using the inverse variance method. In the meta-analysis (n = 338), significantly lower odds of CRCI were associated with Met allele carriers based on the global FACT-Cog score (OR = 0.52, 95% CI 0.29-0.94). Furthermore, Met allele carriers were at lower odds of developing impairment in the domains of memory (OR = 0.34, 95% CI: 0.17-0.70), multitasking (OR = 0.33, 95% CI: 0.18-0.59), and verbal ability (OR = 0.46, 95% CI: 0.24-0.88). Consistent with the previous study, lower odds of subjective CRCI among patients with the BDNF Met allele was observed after adjusting for potential confounders in the multitasking (OR = 0.30, 95% CI: 0.14-0.67) domain. In conclusion, carriers of the BDNF Met allele were protected against global subjective CRCI, particularly in the domains of memory, multitasking, and verbal ability. Our findings further contribute to the understanding of CRCI pathophysiology

Chemical changes and optimisation of acetous fermentation time and mother of vinegar concentration in the production of vinegar-like fermented papaya beverage

Fermentation has been long used as a method to produce beverage of various health benefits. In this research, ripe papaya (Carica papaya) was fermented through alcoholic fermentation using Saccharomyces cerevisiae, followed by acetous fermentation using Acetobacter spp. from mother of vinegar, to reduce wastage of this highly perishable Malaysian fruit. The papaya juice was pasteurised prior to the fermentation process. Optimisation of acetous fermentation was carried out using the response surface methodology (RSM) with central composite rotatable design (CCRD). Acetous fermentation time had shown significant effect on all the chemical characteristics while mother of vinegar concentration did not significantly effect on all the chemical characteristics. The vinegar-like fermented papaya beverage which was produced at the optimum point (Fermentation time = 70.80 h and concentration = 40% mother of vinegar) contained 0.37 ± 0.01% reducing sugar, 3.54 ± 0.36% ethanol, 2.46 ± 0.07% acetic acid, 327.89 ± 3.60 mg GAE/ L total phenolic, 2.32 ± 0.17 mg/100 mL ascorbic acid and 52.40 ± 0.23% mg AA/100 mL free-radical scavenging activity. In conclusion, vinegar-like fermented papaya beverage was successfully produced and its chemical compositions changed from papaya juice to wine and vinegar-like beverage with increased bioactive compounds and antioxidative activity

Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes

To explore the complex genetic architecture of common diseases and traits, we conducted comprehensive PheWAS of ten diseases and 34 quantitative traits in the community-based Taiwan Biobank (TWB). We identified 995 significantly associated loci with 135 novel loci specific to Taiwanese population. Further analyses highlighted the genetic pleiotropy of loci related to complex disease and associated quantitative traits. Extensive analysis on glycaemic phenotypes (T2D, fasting glucose and Hb