Anonymous and Adaptively Secure Revocable IBE with Constant Size Public Parameters

In Identity-Based Encryption (IBE) systems, key revocation is non-trivial. This is because a user's identity is itself a public key. Moreover, the private key corresponding to the identity needs to be obtained from a trusted key authority through an authenticated and secrecy protected channel. So far, there exist only a very small number of revocable IBE (RIBE) schemes that support non-interactive key revocation, in the sense that the user is not required to interact with the key authority or some kind of trusted hardware to renew her private key without changing her public key (or identity). These schemes are either proven to be only selectively secure or have public parameters which grow linearly in a given security parameter. In this paper, we present two constructions of non-interactive RIBE that satisfy all the following three attractive properties: (i) proven to be adaptively secure under the Symmetric External Diffie-Hellman (SXDH) and the Decisional Linear (DLIN) assumptions; (ii) have constant-size public parameters; and (iii) preserve the anonymity of ciphertexts---a property that has not yet been achieved in all the current schemes

Unraveling the nuclear and chloroplast genomes of an agar producing red macroalga, Gracilaria changii (Rhodophyta, Gracilariales)

Agar and agarose have wide applications in food and pharmaceutical industries. Knowledge on the genome of red seaweeds that produce them is still lacking. To fill the gap in genome analyses of these red algae, we have sequenced the nuclear and organellar genomes of an agarophyte, Gracilaria changii. The partial nuclear genome sequence of G. changii has a total length of 35.8 Mb with 10,912 predicted protein coding sequences. Only 39.4% predicted proteins were found to have significant matches to protein sequences in SwissProt. The chloroplast genome of G. changii is 183,855 bp with a total of 201 open reading frames (ORFs), 29 tRNAs and 3 rRNAs predicted. Five genes: ssrA, leuC and leuD CP76_p173 (orf139) and pbsA were absent in the chloroplast genome of G. changii. The genome information is valuable in accelerating functional studies of individual genes and resolving evolutionary relationship of red seaweeds

A Comparative Study of Deep Learning Model and Simple Prediction Charts in Construction Noise Prediction

Construction noise monitoring is crucial to assess the impacts of construction noise on the workers and surroundings. However, the existing noise prediction methods are time-consuming in which required laborious work for the computation of noise levels. This study aims to assess the accuracy and reliability of deep learning model (DL) that adopted stochastic modelling and artificial neural network (ANN) in construction noise prediction. The artificial neural network was trained with the output of stochastic modelling. The outcome of noise level prediction using simple prediction chart (SPC) and DL model was discussed and compared to 3 case studies. The case studies were conducted at construction sites located in Semenyih, Selangor, Malaysia. The results of DL model showed high accuracy of predicted noise levels along with an absolute difference of less than 2.3 dBA. Besides, the predicted noise levels are reliable as the R-squared value is higher than 0.992. On that account, DL model is proved to be reliable and accurate in noise level prediction and it has the potential to be utilized as a managerial tool to monitor construction noise more effectively

Effect of Ceramic Dust as Partial Replacement of Cement on Lightweight Foamed Concrete

Disposal of waste into the landfill causes a severe impact on the environment. One of the waste products is ceramic waste. Ceramic waste has some excellent properties in its durability, hardness, and highly resistant to biological, chemical, and physical degradation forces. These excellent properties of the ceramic waste may make it suitable to be used in concrete. This study investigates the effect on the compressive strength of lightweight foamed concrete with different percentage of ceramic dust replacement level towards the cement and three different levels of water-cement ratio. 0%, 5%, 15%, and 25% of replacement level with 0.52, 0.56, and 0.60 water-cement ratios respectively for each replacement level was used as the parameter to investigate the fresh properties, and strength performance of lightweight foamed concrete. The stability and consistency of every mix are studied as well. From this study, it was observed that the incorporation of ceramic waste dust partially replaced the cement did not affect on the fresh properties of the foamed concrete. However, the compressive strength of foamed concrete affected by ceramic waste dust partially replaced the cement

AP4 transcription factor binding site is a repressor element in ek2 promoter of human liver carcinoma cell line, HepG2

Ethanolamine kinase (EK) is the first enzyme in the Kennedy pathway for the biosynthesis of phosphatidylethanolamine. Although EK has been reported to be involved in phospholipid biosynthesis, carcinogenesis, cell growth, muscle development and sex determination during embryonic development, little is known about its transcriptional regulation by endogenous or exogenous signals. Human EK exists as EK1, EK2α and EK2β isoforms, encoded by two separate genes, named ek1 and ek2. Compared to ek1 gene, ek2 is expressed at a higher level in liver and EK2 isoforms also accept choline as substrate besides ethanolamine, which could contribute to liver carcinogenesis. The main aim of this study was to analyze and characterize the human ek2 promoter in cultured mammalian cells. Human ek2 (2011 bp) promoter was cloned into reporter vector, pGL4.10 [luc2] and the promoter activities were studied in human liver carcinoma (HepG2 cells). Sequence analyses showed that ek2 promoter contains numerous putative transcription factor binding sites including AP4 and it is devoid of a recognizable consensus TATA box but it contains a high number of guanine (G) and cytosine (C) nucleotides. PCR mutagenesis of three nucleotides at E-box motif of AP4 transcription binding site located between -293 and -276 of ek2 promoter was successfully performed to show that AP4 transcription factor binding site acts as a repressive element in the regulation of ek2 expression. AP4 upregulation has been implicated in bad prognosis of carcinoma, therefore the regulatory role of AP4 binding site reported in this study could be a link between ek2 and carcinogenesis. Although further studies need to be carried out to understand and to determine the repression mechanism of AP4 in ek2 promoter, the characterization and analysis of ek promoter performed in this study provide important understanding of its basal transcriptional regulation which would allow us to control ek expression levels in pathologic conditions that involve this gene

Experimental Study on the Flexural Behavior of Reinforced Polystyrene Blocks in Concrete Beams

A new type of lightweight beam system was recently proposed by embedding polystyrene in beams to improve structural efficiency. This removes the non-performing concrete in the neutral axis and tension region to provide a comparable strength as a solid beam. There are, however, limited studies conducted to investigate the structural behavior of such beams. Therefore, this research presents an experimental investigation to assess the effect of polystyrene shapes in the beams. This involved testing a solid beam and five lightweight beams under flexural load using a four-point load test. The inclusion of polystyrene was estimated to have reduced the self-weight of beams by 8.6% to 11.8% when compared with the solid beam. The results also showed the ellipse polystyrene with a width of 70 mm and height of 50 mm produced the highest effective strength to weight ratio (sw) of 1.12 and performed 12% better than the solid beam. Moreover, the lightweight beams have more weight reduced than the strength, and those with ellipse polystyrene were found to have performed better than circular ones based on first crack load, ultimate load, and effective strength to weight ratio (sw). The beams with ellipse polystyrene allowed better stress distribution and this gave them a higher strength than sphere shape. For industry application, the polystyrene content is recommended to be greater than 10% while the effective strength to weight ratio (sw) of the beam is greater than 1. The successful reduction of the weight without affecting the structural performance has the ability to help in reducing construction costs

Portfolio-Based Approach for Disaster Recovery Planning for IT

With the integration of IT with business operations and management, organizations are vulnerable to a myriad of threats ranging from computer viruses to natural disasters and deliberate acts of sabotage. Consequently, IT disaster recovery has emerged as a critical organizational issue. This paper proposes an application portfolio-based framework for IT disaster recovery planning based on the role of IT and the consequence of IT disaster. The findings and recommendations of the paper are based on interviews with disaster recovery experts and senior IT professionals and a case study

Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer\u27s disease, coronary artery disease and type 2 diabetes

Obesity, especially at mid-life, is a major risk factor for atherosclerosis, insulin resistance and the metabolic syndrome, which in turn contrib- ute to coronary artery disease (CAD), Type 2 diabetes and Alzheimer’s disease (AD). The rise in overweight and obesity in all societies is prompting intense research into the causes and effects of the condition. Obesity disrupts many body systems including glucose and lipid me- tabolism, circadian rhythms and liver function. It also causes or increases inflammation and oxi- dative stress. Within cells, the endoplasmic re- ticulum (ER) appears to be particularly suscep- tible to such metabolic disruption. Sirtuin 1 (Sirt1) and leptin have received attention recently as they are central regulatory factors for the body’s metabolic pathways which interact at particular levels, for example lipid and Abeta metabolism. This mini-review discusses recent findings con- cerning obesity, lipid metabolism and the role of Sirtuin 1 and how all influence the ER. A greater understanding of obesity and its effects on me- tabolic control systems of the body are required, to develop pharmacological, dietary and lifestyle changes that will reduce the incidence of CAD, Type 2 diabetes and AD

Agar properties of Gracilaria species (Gracilariaceae, Rhodophyta) collected from different natural habitats in Malaysia

The yield and quality of agar from Gracilaria species collected from distinct natural habitats (mangrove swamp, rocky shore, sandy mudflat) along the west coast of Peninsular Malaysia were evaluated in this study. The agar content was found to be significantly higher in G. changii and G. edulis growing in the mangrove swamp, while the lowest agar content was recorded for G. changii and G. edulis collected from the sandy mudflat. Higher agar gel strength was obtained from the three Gracilaria species collected from the mangrove swamp compared to those that live in the sandy mudflat and rocky shore. The intraspecific variations found in gelling temperature were well correlated with the trend of changes in agar gel strength, except for G. changii collected from the sandy mudflat and rocky shore. The intraspecific and interspecific variations of agar melting temperature did not show a consistent trend for all Gracilaria species tested. The agars of Gracilaria spp. collected from the rocky shore showed a significantly higher gel syneresis while the lowest gel syneresis was recorded for the agars of samples collected from the mangrove swamp, except for the agars of G. salicornia from different habitats which showed no difference. In conclusion, the mangrove swamp is a natural habitat which produces Gracilaria with good agar properties, in terms of agar yield, gel strength and gel hysteresis, thus it can be considered as a potential site for seaweed farming and mariculture for the agar industry in Malaysia

Roles and recommendations from primary care physicians towards managing low-risk breast cancer survivors in a shared-care model with specialists in Singapore-a qualitative study.

BackgroundBreast cancer is prevalent and has high cure rates. The resultant increase in numbers of breast cancer survivors (BCS) may overwhelm the current oncology workforce in years to come. We postulate that primary care physicians (PCPs) could play an expanded role in comanaging survivors, provided they are given the appropriate tools and training to do so.ObjectiveTo explore the perspectives of PCPs towards managing BCS in a community-based shared-care programme with oncologists.MethodsEleven focus groups and six in-depth interviews were conducted with seventy PCPs recruited by purposive sampling. All sessions were audio-recorded, transcribed verbatim and coded by three independent investigators. Thematic data analysis was performed and the coding process facilitated by NVivo 12.ResultsMajority of PCPs reported currently limited roles in managing acute and non-cancer issues, optimizing comorbidities and preventive care. PCPs aspired to expand their role to include cancer surveillance, risk assessment and addressing unmet psychosocial needs. PCPs preferred to harmonize cancer survivorship management of their primary care patients who are also BCS, with defined role distinct from oncologists. Training to understand the care protocol, enhancement of communication skills, confidence and trust were deemed necessary. PCPs proposed selection criteria of BCS and adequacy of their medical information; increased consultation time; contact details and timely access to oncologists (if needed) in the shared-care programme.ConclusionsPCPs were willing to share the care of BCS with oncologists but recommended role definition, training, clinical protocol, resources and access to oncologist's consultation to optimize the programme implementation