The interaction of syllabification and voicing perception in american english

The current paper explores these two sorts of phonetic explanations of the relationship between syllabic position and the voicing contrast in American English. It has long been observed that the contrast between, for example, /p/ and /b/ is expressed differently, depending on the position of the stop with respect to the vowel. Preceding a vowel within a syllable, the contrast is largely one of aspiration. /p/ is aspirated, while /b/ is voiceless, or in some dialects voiced or even an implosive. Following a vowel within a syllable, both /p/ and /b/ both tend to lack voicing in the closure and the contrast is expressed largely by dynamic differences in the transition between the previous vowel and the stop. Here, vowel and closure duration are negatively correlated such that the /p/ has a shorter vowel and longer closure duration. This difference is often enhanced by the addition of glottalization to /p/. In addition to these differences, there are additional differences connected to higher-level organization involving stress and feet edges. To make the current discussion more tractable, we will restrict ourselves to the two conditions (CV and VC) laid out above

Nonprofit Organizations and the Nevada Economy: An analysis of the employment, economic impact, and scope of the nonprofit sector in Nevada

The Nevada nonprofit sector plays an important role in the state’s economy. This research report examines the role of nonprofit organizations in the economy and details regional differences in terms of employment and economic impact in the state

Civic Associations That Work: The Contributions of Leadership to Organizational Effectiveness

Why are some civic associations more effective at advancing their public agendas, engaging members, and developing leaders? We introduce a multi-dimensional framework for analyzing the comparative effectiveness of member-based civic associations in terms of public influence, member engagement, and leader development. Theoretical expectations in organization studies, sociology, political science, and industrial relations hold that organizations benefiting from either a favorable environment or abundant resources will be most effective. Using systematic data on the Sierra Clubs 400 local organizations, we assess these factors alongside an alternative approach focusing on the role of leaders, how they work together, and the activities they carry out to build capacity and conduct programs. While we find modest support for the importance of an organizations available resources and external environment, we find strong evidence for each of our three outcomes supporting our claim that effectiveness in civic associations depends to a large degree on internal organizational practices.This publication is Hauser Center Working Paper No. 36. The Hauser Center Working Paper Series was launched during the summer of 2000. The Series enables the Hauser Center to share with a broad audience important works-in-progress written by Hauser Center scholars and researchers

Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency.

The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeling factors, with causal roles in neurodevelopmental disorders. Chromodomain helicase DNA binding protein 8 (CHD8) encodes a chromatin remodeling factor with among the highest de novo loss-of-function mutation rates in patients with autism spectrum disorder (ASD). However, mechanisms associated with CHD8 pathology have yet to be elucidated. We analyzed published transcriptomic data across CHD8 in vitro and in vivo knockdown and knockout models and CHD8 binding across published ChIP-seq datasets to identify convergent mechanisms of gene regulation by CHD8. Differentially expressed genes (DEGs) across models varied, but overlap was observed between downregulated genes involved in neuronal development and function, cell cycle, chromatin dynamics, and RNA processing, and between upregulated genes involved in metabolism and immune response. Considering the variability in transcriptional changes and the cells and tissues represented across ChIP-seq analysis, we found a surprisingly consistent set of high-affinity CHD8 genomic interactions. CHD8 was enriched near promoters of genes involved in basic cell functions and gene regulation. Overlap between high-affinity CHD8 targets and DEGs shows that reduced dosage of CHD8 directly relates to decreased expression of cell cycle, chromatin organization, and RNA processing genes, but only in a subset of studies. This meta-analysis verifies CHD8 as a master regulator of gene expression and reveals a consistent set of high-affinity CHD8 targets across human, mouse, and rat in vivo and in vitro studies. These conserved regulatory targets include many genes that are also implicated in ASD. Our findings suggest a model where perturbation to dosage-sensitive CHD8 genomic interactions with a highly-conserved set of regulatory targets leads to model-specific downstream transcriptional impacts

Iron-based ferritin nanocore as a contrast agent

Self-assembling protein cages have been exploited as templates for nanoparticle synthesis. The ferritin molecule, a protein cage present in most living systems, stores excess soluble ferrous iron in the form of an insoluble ferric complex within its cavity. Magnetic nanocores formed by loading excess iron within an engineered ferritin from Archaeoglobus fulgidus (AfFtn-AA) were studied as a potential magnetic resonance (MR) imaging contrast agent. The self-assembly characteristics of the AfFtn-AA were investigated using dynamic light scattering technique and size exclusion chromatography. Homogeneous size distribution of the assembled nanoparticles was observed using transmission electron microscopy. The magnetic properties of iron-loaded AfFtn-AA were studied using vibrating sample magnetometry. Images obtained from a 3.0 T whole-body MRI scanner showed significant brightening of T1 images and signal loss of T2 images with increased concentrations of iron-loaded AfFtn-AA. The analysis of the MR image intensities showed extremely high R2 values (5300 mM^(−1) s^(−1)) for the iron-loaded AfFtn-AA confirming its potential as a T2 contrast agent

Continuous Stress Monitoring under Varied Demands Using Unobtrusive Devices

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.This research aims to identify a feasible model to predict a learner’s stress in an online learning platform. It is desirable to produce a cost-effective, unobtrusive and objective method to measure a learner’s emotions. The few signals produced by mouse and keyboard could enable such solution to measure real world individual’s affective states. It is also important to ensure that the measurement can be applied regardless the type of task carried out by the user. This preliminary research proposes a stress classification method using mouse and keystroke dynamics to classify the stress levels of 190 university students when performing three different e-learning activities. The results show that the stress measurement based on mouse and keystroke dynamics is consistent with the stress measurement according to the changes of duration spent between two consecutive questions. The feedforward back-propagation neural network achieves the best performance in the classification

Acute Kidney Injury: Controversies Revisited

This paper addresses the epidemiology of AKI specifically in relation to recent changes in AKI classification and revisits the controversies regarding the timing of initiation of dialysis and the use of peritoneal dialysis as a renal replacement therapy for AKI. In summary, the new RIFLE/AKIN classifications of AKI have facilitated more uniform diagnosis of AKI and clinically significant risk stratification. Regardless, the issue of timing of dialysis initiation still remains unanswered and warrants further examination. Furthermore, peritoneal dialysis as a treatment modality for AKI remains underutilised in spite of potential beneficial effects. Future research should be directed at identifying early reliable biomarkers of AKI, which in conjunction with RIFLE/AKIN classifications of AKI could facilitate well-designed large randomised controlled trials of early versus late initiation of dialysis in AKI. In addition, further studies of peritoneal dialysis in AKI addressing dialysis dose and associated complications are required for this therapy to be accepted more widely by clinicians

Pseudo-solidification of dredged marine soils with cement - fly ash for reuse in coastal development

The dislodged and removed sediments from the seabed, termed dredged marine soils, are generally classified as a waste material requiring special disposal procedures. This is due to the potential contamination risks of transporting and disposing the dredged soils, and the fact that the material is of poor engineering quality, unsuitable for usage as a conventional good soil in construction. Also, taking into account the incurred costs and risk exposure in transferring the material to the dump site, whether on land or offshore, it is intuitive to examine the possibilities of reusing the dredged soils, especially in coastal development where the transportation route would be of shorter distance between the dredged site and the construction location. Pseudo-solidification of soils is not a novel idea though, where hydraulic binders are injected and mixed with soils to improve the inherent engineering properties for better load bearing capacity. It is commonly used on land in areas with vast and deep deposits of soft, weak soils. However, to implement the technique on the displaced then replaced dredged soil would require careful study, as the material is far more poorly than their land counterparts, and that the deployment of equipment and workforce in a coastal environment is understandably more challenging. The paper illustrates the laboratory investigation of the improved engineering performance of dredged marine soil sample with cement and fly ash blend. Some key findings include optimum dosage of cement and fly ash mix to produce up to 30 times of small strain stiffness improvement, pre-yield settlement reduction of the treated soil unaffected by prolonged curing period, and damage of the cementitious bonds formed by the rather small dosage of admixtures in the soil post-yield. In short, the test results show a promising reuse potential of the otherwise discarded dredged marine soils